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• W2100801626 abstract "Working with isolated perfused S2 proximal tubules, we asked whether the basolateral CO 2 sensor acts, in part, by raising intracellular Ca 2 + concentration ([Ca 2 + ] i ), monitored with the dye fura 2 (or fura-PE3). In paired experiments, adding 5% CO 2 /22 mM [Formula: see text] (constant pH 7.40) to the bath (basolateral) solution caused [Ca 2 + ] i to increase from 57 ± 3 to 97 ± 9nM( n = 8, P < 0.002), whereas the same maneuver in the lumen had no effect. Intracellular pH (pH i ), measured with the dye BCECF, fell by 0.54 ± 0.08 ( n = 14) when we added [Formula: see text] to the lumen. In 14 tubules in which we added [Formula: see text] to the bath, pH i fell by 0.55 ± 0.11 in 9 with a high initial pH i , but rose by 0.28 ± 0.07 in the other 5 with a low initial pH i . Thus it cannot be a pH i change that triggers the [Ca 2 + ] i increase. Introducing to the bath an out-of-equilibrium (OOE) solution containing 20% CO 2 /no [Formula: see text] caused [Ca 2 + ] i to rise by 62 ± 17 nM ( n = 10), whereas an OOE solution containing 0% CO 2 /22 mM [Formula: see text] caused only a trivial increase. Removing Ca 2 + from the lumen and bath, or adding 10 μM nifedipine (L- and T-type Ca 2 + -channel blocker) or 2 μM thapsigargin [sarco-(endo) plasmic reticulum Ca 2 + -ATPase inhibitor] or 4 μM rotenone (mitochondrial inhibitor) to the lumen and bath, failed to reduce the CO 2 -induced increase in [Ca 2 + ] i . Adding 10 mM caffeine (ryanodine-receptor agonist) had no effect on [Ca 2 + ] i . Thus basolateral CO 2 , presumably via a basolateral sensor, triggers the release of Ca 2 + from a nonconventional intracellular pool." @default.
• W2100801626 created "2016-06-24" @default.
• W2100801626 creator A5015908458 @default.
• W2100801626 creator A5076212397 @default.
• W2100801626 creator A5084438654 @default.
• W2100801626 date "2003-10-01" @default.
• W2100801626 modified "2023-09-27" @default.
• W2100801626 title "An increase in intracellular calcium concentration that is induced by basolateral CO2 in rabbit renal proximal tubule" @default.
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• W2100801626 doi "https://doi.org/10.1152/ajprenal.00107.2003" @default.
• W2100801626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12812914" @default.
• W2100801626 hasPublicationYear "2003" @default.
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