FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100805144> ?p ?o ?g. }

• W2100805144 endingPage "140" @default.
• W2100805144 startingPage "132" @default.
• W2100805144 abstract "Determining how genes are epigenetically regulated to ensure their correct spatial and temporal expression during development is key to our understanding of cell lineage commitment. Here we examined epigenetic changes at an important proneural regulator gene Mash1 (Ascl1), as embryonic stem (ES) cells commit to the neural lineage. In ES cells where the Mash1 gene is transcriptionally repressed, the locus replicated late in S phase and was preferentially positioned at the nuclear periphery with other late-replicating genes (Neurod, Sprr2a). This peripheral location was coupled with low levels of histone H3K9 acetylation at the Mash1 promoter and enhanced H3K27 methylation but surprisingly location was not affected by removal of the Ezh2/Eed HMTase complex or several other chromatin-silencing candidates (G9a, SuV39h-1, Dnmt-1, Dnmt-3a and Dnmt-3b). Upon neural induction however, Mash1 transcription was upregulated (&gt;100-fold), switched its time of replication from late to early in S phase and relocated towards the interior of the nucleus. This spatial repositioning was selective for neural commitment because Mash1 was peripheral in ES-derived mesoderm and other non-neural cell types. A bidirectional analysis of replication timing across a 2 Mb region flanking the Mash1 locus showed that chromatin changes were focused at Mash1. These results suggest that Mash1 is regulated by changes in chromatin structure and location and implicate the nuclear periphery as an important environment for maintaining the undifferentiated state of ES cells." @default.
• W2100805144 created "2016-06-24" @default.
• W2100805144 creator A5006704636 @default.
• W2100805144 creator A5021026821 @default.
• W2100805144 creator A5022128162 @default.
• W2100805144 creator A5033590861 @default.
• W2100805144 creator A5040778444 @default.
• W2100805144 creator A5041171993 @default.
• W2100805144 creator A5043928262 @default.
• W2100805144 creator A5064598051 @default.
• W2100805144 creator A5073285869 @default.
• W2100805144 creator A5085836059 @default.
• W2100805144 creator A5091535581 @default.
• W2100805144 date "2006-01-01" @default.
• W2100805144 modified "2023-10-07" @default.
• W2100805144 title "Neural induction promotes large-scale chromatin reorganisation of the <i>Mash1</i> locus" @default.
• W2100805144 cites W1528082486 @default.
• W2100805144 cites W1528795260 @default.
• W2100805144 cites W1788737630 @default.
• W2100805144 cites W1951165114 @default.
• W2100805144 cites W1966476278 @default.
• W2100805144 cites W1968554285 @default.
• W2100805144 cites W1972992333 @default.
• W2100805144 cites W1973860395 @default.
• W2100805144 cites W1976623855 @default.
• W2100805144 cites W1977339483 @default.
• W2100805144 cites W1977995035 @default.
• W2100805144 cites W1982295124 @default.
• W2100805144 cites W1983170790 @default.
• W2100805144 cites W1987659565 @default.
• W2100805144 cites W1988369300 @default.
• W2100805144 cites W1992949513 @default.
• W2100805144 cites W1994024125 @default.
• W2100805144 cites W2009905005 @default.
• W2100805144 cites W2010295908 @default.
• W2100805144 cites W2018816192 @default.
• W2100805144 cites W2019923915 @default.
• W2100805144 cites W2021919933 @default.
• W2100805144 cites W2025660464 @default.
• W2100805144 cites W2026755238 @default.
• W2100805144 cites W2033907031 @default.
• W2100805144 cites W2034575423 @default.
• W2100805144 cites W2036624970 @default.
• W2100805144 cites W2043655216 @default.
• W2100805144 cites W2048163917 @default.
• W2100805144 cites W2049928107 @default.
• W2100805144 cites W2051525713 @default.
• W2100805144 cites W2063989075 @default.
• W2100805144 cites W2068814192 @default.
• W2100805144 cites W2087126781 @default.
• W2100805144 cites W2091136433 @default.
• W2100805144 cites W2091373076 @default.
• W2100805144 cites W2091496842 @default.
• W2100805144 cites W2093332176 @default.
• W2100805144 cites W20935937 @default.
• W2100805144 cites W2094583929 @default.
• W2100805144 cites W2095169145 @default.
• W2100805144 cites W2099449240 @default.
• W2100805144 cites W2102599158 @default.
• W2100805144 cites W2110241629 @default.
• W2100805144 cites W2111424853 @default.
• W2100805144 cites W2111473969 @default.
• W2100805144 cites W2127517570 @default.
• W2100805144 cites W2128978430 @default.
• W2100805144 cites W2135271276 @default.
• W2100805144 cites W2138165389 @default.
• W2100805144 cites W2140125310 @default.
• W2100805144 cites W2144050547 @default.
• W2100805144 cites W2146427646 @default.
• W2100805144 cites W2158499654 @default.
• W2100805144 cites W2160908077 @default.
• W2100805144 cites W2161507965 @default.
• W2100805144 cites W2167299299 @default.
• W2100805144 cites W4298410792 @default.
• W2100805144 doi "https://doi.org/10.1242/jcs.02727" @default.
• W2100805144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16371653" @default.
• W2100805144 hasPublicationYear "2006" @default.
• W2100805144 type Work @default.
• W2100805144 sameAs 2100805144 @default.
• W2100805144 citedByCount "271" @default.
• W2100805144 countsByYear W21008051442012 @default.
• W2100805144 countsByYear W21008051442013 @default.
• W2100805144 countsByYear W21008051442014 @default.
• W2100805144 countsByYear W21008051442015 @default.
• W2100805144 countsByYear W21008051442016 @default.
• W2100805144 countsByYear W21008051442017 @default.
• W2100805144 countsByYear W21008051442018 @default.
• W2100805144 countsByYear W21008051442019 @default.
• W2100805144 countsByYear W21008051442020 @default.
• W2100805144 countsByYear W21008051442021 @default.
• W2100805144 countsByYear W21008051442022 @default.
• W2100805144 countsByYear W21008051442023 @default.
• W2100805144 crossrefType "journal-article" @default.
• W2100805144 hasAuthorship W2100805144A5006704636 @default.
• W2100805144 hasAuthorship W2100805144A5021026821 @default.
• W2100805144 hasAuthorship W2100805144A5022128162 @default.
• W2100805144 hasAuthorship W2100805144A5033590861 @default.
• W2100805144 hasAuthorship W2100805144A5040778444 @default.

• next