FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100810588> ?p ?o ?g. }

• W2100810588 endingPage "e000030" @default.
• W2100810588 startingPage "e000030" @default.
• W2100810588 abstract "Measuring amyloid and predicting tau status using a single amyloid PET study would be valuable for assessing brain AD pathophysiology. We hypothesized that early-frame amyloid PET (efAP) correlates with the presence of tau pathology because the initial regional brain concentrations of radioactivity are determined primarily by blood flow, which is expected to be decreased in the setting of tau pathology. <b>Methods:</b> The study included 120 participants (63 amyloid-positive and 57 amyloid-negative) with dynamic ¹⁸F-florbetapir PET and static ¹⁸F-flortaucipir PET scans obtained within 6 mo of each other. These subjects were predominantly cognitively intact in both the amyloid-positive (63%) and the amyloid-negative (93%) groups. Parameters for efAP quantification were optimized for stratification of tau PET positivity, assessed by either a tauopathy score or Braak regions. The ability of efAP to stratify tau positivity was measured using receiver-operating-characteristic analysis of area under the curve (AUC). Pearson <i>r</i> and Spearman ρ were used for parametric and nonparametric comparisons between efAP and tau PET, respectively. Standardized net benefit was used to evaluate improvement in using efAP as an additional copredictor over hippocampal volume in predicting tau PET positivity. <b>Results:</b> Measuring efAP within the hippocampus and summing the first 3 min of brain activity after injection showed the strongest discriminative ability to stratify for tau positivity (AUC, 0.67–0.89 across tau PET Braak regions) in amyloid-positive individuals. Hippocampal efAP correlated significantly with a global tau PET tauopathy score in amyloid-positive participants (<i>r</i> = −0.57, <i>P</i> < 0.0001). Compared with hippocampal volume, hippocampal efAP showed a stronger association with tau PET Braak stage (ρ = −0.58 vs. −0.37) and superior stratification of tau PET tauopathy score (AUC, 0.86 vs. 0.66; <i>P</i> = 0.002). <b>Conclusion:</b> Hippocampal efAP can provide additional information to conventional amyloid PET, including estimation of the likelihood of tau positivity in amyloid-positive individuals." @default.
• W2100810588 created "2016-06-24" @default.
• W2100810588 creator A5005998699 @default.
• W2100810588 creator A5011082069 @default.
• W2100810588 creator A5021992942 @default.
• W2100810588 creator A5037153598 @default.
• W2100810588 creator A5041749838 @default.
• W2100810588 creator A5065582919 @default.
• W2100810588 creator A5082657664 @default.
• W2100810588 creator A5084142962 @default.
• W2100810588 creator A5086399099 @default.
• W2100810588 date "2011-02-26" @default.
• W2100810588 modified "2023-10-03" @default.
• W2100810588 title "Feasibility of self-sampling and human papillomavirus testing for cervical cancer screening in First Nation women from Northwest Ontario, Canada: a pilot study" @default.
• W2100810588 cites W1513630550 @default.
• W2100810588 cites W1517229975 @default.
• W2100810588 cites W1537342856 @default.
• W2100810588 cites W1856142903 @default.
• W2100810588 cites W1971933024 @default.
• W2100810588 cites W1978915215 @default.
• W2100810588 cites W2009775385 @default.
• W2100810588 cites W2015154915 @default.
• W2100810588 cites W2040040787 @default.
• W2100810588 cites W2047145143 @default.
• W2100810588 cites W2049214508 @default.
• W2100810588 cites W2053336325 @default.
• W2100810588 cites W2056362005 @default.
• W2100810588 cites W2080642222 @default.
• W2100810588 cites W2096372086 @default.
• W2100810588 cites W2096478290 @default.
• W2100810588 cites W2097373332 @default.
• W2100810588 cites W2098752968 @default.
• W2100810588 cites W2099372482 @default.
• W2100810588 cites W2102499315 @default.
• W2100810588 cites W2111014562 @default.
• W2100810588 cites W2111502179 @default.
• W2100810588 cites W2112859230 @default.
• W2100810588 cites W2125165741 @default.
• W2100810588 cites W2137482496 @default.
• W2100810588 cites W214332893 @default.
• W2100810588 cites W2145032328 @default.
• W2100810588 cites W2146459254 @default.
• W2100810588 cites W2148585388 @default.
• W2100810588 cites W2160927412 @default.
• W2100810588 cites W2334669230 @default.
• W2100810588 cites W2409403815 @default.
• W2100810588 cites W2414233401 @default.
• W2100810588 cites W652514692 @default.
• W2100810588 doi "https://doi.org/10.1136/bmjopen-2010-000030" @default.
• W2100810588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3191400" @default.
• W2100810588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22021733" @default.
• W2100810588 hasPublicationYear "2011" @default.
• W2100810588 type Work @default.
• W2100810588 sameAs 2100810588 @default.
• W2100810588 citedByCount "50" @default.
• W2100810588 countsByYear W21008105882012 @default.
• W2100810588 countsByYear W21008105882013 @default.
• W2100810588 countsByYear W21008105882014 @default.
• W2100810588 countsByYear W21008105882015 @default.
• W2100810588 countsByYear W21008105882016 @default.
• W2100810588 countsByYear W21008105882017 @default.
• W2100810588 countsByYear W21008105882018 @default.
• W2100810588 countsByYear W21008105882019 @default.
• W2100810588 countsByYear W21008105882020 @default.
• W2100810588 countsByYear W21008105882021 @default.
• W2100810588 countsByYear W21008105882022 @default.
• W2100810588 crossrefType "journal-article" @default.
• W2100810588 hasAuthorship W2100810588A5005998699 @default.
• W2100810588 hasAuthorship W2100810588A5011082069 @default.
• W2100810588 hasAuthorship W2100810588A5021992942 @default.
• W2100810588 hasAuthorship W2100810588A5037153598 @default.
• W2100810588 hasAuthorship W2100810588A5041749838 @default.
• W2100810588 hasAuthorship W2100810588A5065582919 @default.
• W2100810588 hasAuthorship W2100810588A5082657664 @default.
• W2100810588 hasAuthorship W2100810588A5084142962 @default.
• W2100810588 hasAuthorship W2100810588A5086399099 @default.
• W2100810588 hasBestOaLocation W21008105881 @default.
• W2100810588 hasConcept C126322002 @default.
• W2100810588 hasConcept C142724271 @default.
• W2100810588 hasConcept C143998085 @default.
• W2100810588 hasConcept C148762608 @default.
• W2100810588 hasConcept C2775842073 @default.
• W2100810588 hasConcept C2776925932 @default.
• W2100810588 hasConcept C2777633098 @default.
• W2100810588 hasConcept C2777739294 @default.
• W2100810588 hasConcept C2779134260 @default.
• W2100810588 hasConcept C2779483572 @default.
• W2100810588 hasConcept C2780906993 @default.
• W2100810588 hasConcept C2989005 @default.
• W2100810588 hasConcept C58471807 @default.
• W2100810588 hasConcept C71924100 @default.
• W2100810588 hasConceptScore W2100810588C126322002 @default.
• W2100810588 hasConceptScore W2100810588C142724271 @default.
• W2100810588 hasConceptScore W2100810588C143998085 @default.
• W2100810588 hasConceptScore W2100810588C148762608 @default.
• W2100810588 hasConceptScore W2100810588C2775842073 @default.
• W2100810588 hasConceptScore W2100810588C2776925932 @default.
• W2100810588 hasConceptScore W2100810588C2777633098 @default.

• next