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• W2100821353 abstract "Background: The presence of hepatitis B virus (HBV) DNA in parallel with the absence of a measurable amount of hepatitis B surface antigen (HBsAg) in periphery of hepatitis B-contaminated carriers is characterized as occult hepatitis B infection (OBI). Its clinical status has resulted in multiple drawbacks for blood transfusion services worldwide. Therefore, the aim of the current study was to investigate the association between polymorphisms in -1443 region of C-X-C motif chemokine 10 (CXCL10) interferon-inducible protein-10 (IP-10) and its plasma level in patients with post-transfusion transmitted OBI. Material and Methods: In this experimental study, plasma samples from 3700 blood donors were tested for HBsAg and anti-hepatitis B core antibody (HBc) by enzyme-linked immunosorbent assay (ELISA). The HBsAg-/ anti-HBc+ samples were selected and screened for HBV-DNA by polymerase chain reaction (PCR). Hepatitis B virus DNA-positive samples considered OBI cases, and a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to examine the polymorphisms in the CXCL10 (IP10) gene. The plasma levels of CXCL10 (IP-10) were also detected using ELISA. Results: The results of this study demonstrated that 352 (9.5%) out of 3700 blood samples were HBsAg-/anti-HBc+, and HBV DNA was detected in 57/352 (16.1%) of HBsAg-/antiHBc+ samples. The results of this study also showed that the plasma level of IP-10 was 87.59 ± 8.75 and 143.5 ± 4.83 pg/mL in OBI patients and healthy controls, respectively. Statistical analysis showed the difference was significant (P<0.001). Our results also showed that all of the patients and healthy controls had AG genotypes, while other genotypes were not seen in patients and controls. Conclusion: According to the findings of this study, it can be concluded that OBI patients lack the ability to express adequate amounts of IP-10 that could probably affect the process of HBV clearance." @default.
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• W2100821353 date "2011-07-01" @default.
• W2100821353 modified "2023-09-27" @default.
• W2100821353 title "Decreased Circulating Level in Parallel With Lack of Associated Genetic Variation in CXCL10 (IP-10) in Southeastern Post-Transfusion Occult HBV-Infected Patients" @default.
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• W2100821353 doi "https://doi.org/10.1309/lm1i1ll2guxfqhol" @default.
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