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• W2100855302 abstract "Changes in the intracellular calcium ion concentration ([Ca2+]i) of monocytes. granulocytes. and NK eells have been studied following either (1) independent cross-linking of Fcγ receptors (FcγR) I, H, or III, with F(abγ')2 fragments of monoclonal antibodies: or (2) linking ofa selected FcγR to a tumour cell target with bispecilic F(ab'γ)2 antibodies. Upon cross-linking each FcγR with antibody an increase in the ([Ca2+]i), was observed, although all receptors apart from FcγRIII on NK cells required additional cross-linking with an anti-mouse Fab', These results indicale that each type of receptor can transduce signals to the cell independently, Bispecific antibodies (anti-FcyR X anti-target) linking cytotoxic FcyR-bearing effector cells to tumour target cells also mediated increases in ([Ca2+]i) for all FcγR tested except for FcγRIII on granulocytes. The failure to transduce a signal via ihis receptor may be related to the GPI link, which is in contrast to the transmembrane link of Fcγ RIII on NK cells. Significant lysis of tumour cell targets occurred when bispecific antibodies recruited NK cells or monocytes. bul not granulocytes, via FcγR. Chelation of intracellular Ca2+i in the effector cells redueed the observed lysis, suggesting a role for Ca2+i in the pathways leading to cytotoxicity." @default.
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• W2100855302 date "1992-08-01" @default.
• W2100855302 modified "2023-09-27" @default.
• W2100855302 title "Cytoplasmic Calcium Fluxes Induced in Cytotoxic Effector Cells by Engagement of Fcgamma Receptors I, II, and III" @default.
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• W2100855302 doi "https://doi.org/10.1111/j.1365-3083.1992.tb03094.x" @default.
• W2100855302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1386938" @default.
• W2100855302 hasPublicationYear "1992" @default.
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