FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100860198> ?p ?o ?g. }

• W2100860198 endingPage "948" @default.
• W2100860198 startingPage "945" @default.
• W2100860198 abstract "The dysregulated cytokine network in Sjögren's Syndrome (SS) is reflected by local and systemic overexpression of pro-inflammatory cytokines and absent or low levels of anti-inflammatory cytokines. To date, the use of cytokine based therapies in SS has been disappointing. Oral administration of low dose interferon (IFN) α showed inconsistent efficacy in various studies and failed to achieve the primary endpoint in a pivotal randomised controlled trial. Similarly, neither of the two tumour necrosis factor (TNF)-α blockers tested (etanercept and infliximab) showed efficacy in placebo controlled trials. Although the rationale for low dose oral IFN treatment has not been firmly established, TNF blockade was based on solid preclinical data. Therefore, the reason for the lack of efficacy is unclear, but recent data suggest that unexpected biological effects of TNF antagonists may have contributed to this. Cytokines, given their central role in the pathogenesis of SS, remain attractive targets for future treatments, despite the disappointing early results. Inflammatory cytokines are obvious candidates, and agents against several of them are available or under development for other autoimmune diseases similar to SS. New candidate cytokines such as IL-17 and IL-12 and/or IL-23 may provide promising targets for SS. Additionally, as an alternative to systemic treatment, which has the risk of potentially severe side effects, the use of local cytokine directed therapy should be explored." @default.
• W2100860198 created "2016-06-24" @default.
• W2100860198 creator A5012564728 @default.
• W2100860198 creator A5045259317 @default.
• W2100860198 creator A5076613698 @default.
• W2100860198 date "2010-04-21" @default.
• W2100860198 modified "2023-10-07" @default.
• W2100860198 title "Cytokines in Sjögren's syndrome: potential therapeutic targets" @default.
• W2100860198 cites W1549441204 @default.
• W2100860198 cites W1970702209 @default.
• W2100860198 cites W1986628830 @default.
• W2100860198 cites W1995789323 @default.
• W2100860198 cites W1999967054 @default.
• W2100860198 cites W2005367309 @default.
• W2100860198 cites W2016447788 @default.
• W2100860198 cites W2027401883 @default.
• W2100860198 cites W2028692877 @default.
• W2100860198 cites W2043298079 @default.
• W2100860198 cites W2048405539 @default.
• W2100860198 cites W2049858255 @default.
• W2100860198 cites W2051649686 @default.
• W2100860198 cites W2055339820 @default.
• W2100860198 cites W2057962630 @default.
• W2100860198 cites W2059189040 @default.
• W2100860198 cites W2064269972 @default.
• W2100860198 cites W2079494090 @default.
• W2100860198 cites W2087905758 @default.
• W2100860198 cites W2110761777 @default.
• W2100860198 cites W2111233953 @default.
• W2100860198 cites W2132513869 @default.
• W2100860198 cites W2136811387 @default.
• W2100860198 cites W2137308839 @default.
• W2100860198 cites W2143819913 @default.
• W2100860198 cites W2150952126 @default.
• W2100860198 cites W2163927668 @default.
• W2100860198 cites W2175593968 @default.
• W2100860198 cites W2415092114 @default.
• W2100860198 doi "https://doi.org/10.1136/ard.2009.115378" @default.
• W2100860198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3044243" @default.
• W2100860198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20410069" @default.
• W2100860198 hasPublicationYear "2010" @default.
• W2100860198 type Work @default.
• W2100860198 sameAs 2100860198 @default.
• W2100860198 citedByCount "101" @default.
• W2100860198 countsByYear W21008601982012 @default.
• W2100860198 countsByYear W21008601982013 @default.
• W2100860198 countsByYear W21008601982014 @default.
• W2100860198 countsByYear W21008601982015 @default.
• W2100860198 countsByYear W21008601982016 @default.
• W2100860198 countsByYear W21008601982017 @default.
• W2100860198 countsByYear W21008601982018 @default.
• W2100860198 countsByYear W21008601982019 @default.
• W2100860198 countsByYear W21008601982020 @default.
• W2100860198 countsByYear W21008601982021 @default.
• W2100860198 countsByYear W21008601982022 @default.
• W2100860198 countsByYear W21008601982023 @default.
• W2100860198 crossrefType "journal-article" @default.
• W2100860198 hasAuthorship W2100860198A5012564728 @default.
• W2100860198 hasAuthorship W2100860198A5045259317 @default.
• W2100860198 hasAuthorship W2100860198A5076613698 @default.
• W2100860198 hasBestOaLocation W21008601982 @default.
• W2100860198 hasConcept C126322002 @default.
• W2100860198 hasConcept C164027704 @default.
• W2100860198 hasConcept C17991360 @default.
• W2100860198 hasConcept C203014093 @default.
• W2100860198 hasConcept C2776914184 @default.
• W2100860198 hasConcept C2777138892 @default.
• W2100860198 hasConcept C2777226972 @default.
• W2100860198 hasConcept C2778690821 @default.
• W2100860198 hasConcept C535046627 @default.
• W2100860198 hasConcept C71924100 @default.
• W2100860198 hasConcept C98274493 @default.
• W2100860198 hasConceptScore W2100860198C126322002 @default.
• W2100860198 hasConceptScore W2100860198C164027704 @default.
• W2100860198 hasConceptScore W2100860198C17991360 @default.
• W2100860198 hasConceptScore W2100860198C203014093 @default.
• W2100860198 hasConceptScore W2100860198C2776914184 @default.
• W2100860198 hasConceptScore W2100860198C2777138892 @default.
• W2100860198 hasConceptScore W2100860198C2777226972 @default.
• W2100860198 hasConceptScore W2100860198C2778690821 @default.
• W2100860198 hasConceptScore W2100860198C535046627 @default.
• W2100860198 hasConceptScore W2100860198C71924100 @default.
• W2100860198 hasConceptScore W2100860198C98274493 @default.
• W2100860198 hasIssue "6" @default.
• W2100860198 hasLocation W21008601981 @default.
• W2100860198 hasLocation W21008601982 @default.
• W2100860198 hasLocation W21008601983 @default.
• W2100860198 hasLocation W21008601984 @default.
• W2100860198 hasLocation W21008601985 @default.
• W2100860198 hasOpenAccess W2100860198 @default.
• W2100860198 hasPrimaryLocation W21008601981 @default.
• W2100860198 hasRelatedWork W2024046618 @default.
• W2100860198 hasRelatedWork W2122265491 @default.
• W2100860198 hasRelatedWork W2125935509 @default.
• W2100860198 hasRelatedWork W2128288007 @default.
• W2100860198 hasRelatedWork W2200007585 @default.
• W2100860198 hasRelatedWork W2252829258 @default.
• W2100860198 hasRelatedWork W2404101318 @default.

• next