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- W2100860369 endingPage "1981" @default.
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- W2100860369 abstract "As cancer immunotherapy continues to benefit from novel approaches which cut immune ‘brake pedals’ (e.g. anti-PD1 and anti-CTLA4 antibodies) and push immune cell gas pedals (e.g. IL2, and IFNα) there will be increasing need to develop immune ‘steering wheels’ such as vaccines to guide the immune system specifically toward tumor associated antigens. Two primary hurdles in cancer vaccines have been: identification of universal antigens to be used in ‘off-the-shelf’ vaccines for common cancers, and 2) logistical hurdles of ex vivo production of individualized whole tumor cell vaccines. Here we summarize approaches using ‘in situ vaccination’ in which intratumoral administration of off-the-shelf immunomodulators have been developed to specifically induce (or amplify) T cell responses to each patient's individual tumor. Clinical studies have confirmed the induction of systemic immune and clinical responses to such approaches and preclinical models have suggested ways to further potentiate the translation of in situ vaccine trials for our patients." @default.
- W2100860369 created "2016-06-24" @default.
- W2100860369 creator A5017559600 @default.
- W2100860369 creator A5025820941 @default.
- W2100860369 creator A5030538658 @default.
- W2100860369 date "2015-11-10" @default.
- W2100860369 modified "2023-10-14" @default.
- W2100860369 title "<i>In situ</i>vaccination: Cancer immunotherapy both personalized<i>and</i>off-the-shelf" @default.
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