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• W2100863754 abstract "1 Lipocortin-1 and its N-terminal derivatives exert potent inhibitory actions in various models of acute inflammation. The present study examined the ability of lipocortin (LC)-1 to suppress the release of the acute pro-inflammatory mediators, tumour necrosis factor (TNFα) and prostaglandin E2 (PGE2) from human peripheral blood mononuclear cells (PBMC) stimulated with lipopolysaccharide (LPS) or recombinant human interleukin-1β (rhIL-1β). 2 LPS (10 μg ml−1)-stimulated release of TNFα and PGE2 from PBMC was significantly inhibited by (4 h) co-incubation of the cells with 10−6 m dexamethasone (Dex), but not with 10−9 m to 10−7 m of a N-terminal fragment (amino acids 1–188) of recombinant human LC-1 (LC-1 fragment). However, Dex suppression of LPS-stimulated TNFα and PGE2 secretion from PBMC was reversed when polyclonal antibody to LC-1 fragment (1:10,000 dilution) was included in the medium. rhIL-1β (5times10−8 m)-stimulated release of TNFα and PGE2 from PBMC (after 18 h) was abolished by co-incubation of the cells with 10−7 m LC-1 fragment. 3 After incubation with Dex (4 h), cellular proteins from PBMC were immunoblotted using anti-LC-1 fragment antibody (which showed no cross-reactivity with human annexins 2 to 6). Dex caused no increase in immunoreactive (ir)LC-1 content of PBMC, although there was a three fold increase in the amount of a lower mass species with LC-1-like immunoreactivity. This was accompanied by the appearance of irLC-1 in the extracellular medium. 4 The results of the present study implicate endogenous LC-1 in glucocorticoid suppression of TNFα and PGE2 release from human PBMC and suggest an extracellular site of action for LC-1. LC-1 may also inhibit rhIL-1β-stimulated TNFα and PGE2 secretion from PBMC." @default.
• W2100863754 created "2016-06-24" @default.
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• W2100863754 date "1996-04-01" @default.
• W2100863754 modified "2023-10-18" @default.
• W2100863754 title "The role of lipocortin-1 in dexamethasone-induced suppression of PGE2 and TNFα release from human peripheral blood mononuclear cells" @default.
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• W2100863754 doi "https://doi.org/10.1111/j.1476-5381.1996.tb15305.x" @default.
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