FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100900404> ?p ?o ?g. }

• W2100900404 endingPage "10184" @default.
• W2100900404 startingPage "10177" @default.
• W2100900404 abstract "Vaccinia H1-related phosphatase (VHR) is classified as a dual specificity phosphatase. Unlike typical dual specificity phosphatases, VHR lacks the MAPK-binding domain and shows poor activity against MAPKs. We found that EGF receptor (EGFR) was a direct substrate of VHR and that overexpression of VHR down-regulated EGFR phosphorylation, particularly at Tyr-992 residue. Expression of VHR inhibited the activation of phospholipase Cγ and protein kinase C, both downstream effectors of Tyr-992 phosphorylation of EGFR. Decreasing VHR expression by RNA interference caused higher EGFR phosphorylation at Tyr-992. In addition to EGFR, VHR also directly dephosphorylated ErbB2. Consistent with these results, suppression of VHR augmented the foci formation ability of H1299 non-small cell lung cancer (NSCLC) cells, whereas overexpression of VHR suppressed cell growth in both two- and three-dimensional cultures. Expression of VHR also suppressed tumor formation in a mouse xenograft model. Furthermore, VHR expression was significantly lower in NSCLC tissues in comparison to that in normal lung tissues. Collectively, this study shows that down-regulation of VHR expression enhances the signaling of ErbB receptors and may be involved in NSCLC pathogenesis." @default.
• W2100900404 created "2016-06-24" @default.
• W2100900404 creator A5003682134 @default.
• W2100900404 creator A5005081854 @default.
• W2100900404 creator A5008624768 @default.
• W2100900404 creator A5018443439 @default.
• W2100900404 creator A5030810562 @default.
• W2100900404 creator A5032297429 @default.
• W2100900404 creator A5039503085 @default.
• W2100900404 creator A5040670147 @default.
• W2100900404 creator A5055318160 @default.
• W2100900404 creator A5061765669 @default.
• W2100900404 creator A5063575006 @default.
• W2100900404 date "2011-03-01" @default.
• W2100900404 modified "2023-10-07" @default.
• W2100900404 title "Vaccinia H1-related Phosphatase Is a Phosphatase of ErbB Receptors and Is Down-regulated in Non-small Cell Lung Cancer" @default.
• W2100900404 cites W1491559816 @default.
• W2100900404 cites W1504762918 @default.
• W2100900404 cites W1532341958 @default.
• W2100900404 cites W1560650269 @default.
• W2100900404 cites W1720535299 @default.
• W2100900404 cites W1968474526 @default.
• W2100900404 cites W1979881407 @default.
• W2100900404 cites W1993634249 @default.
• W2100900404 cites W1993905451 @default.
• W2100900404 cites W2003736664 @default.
• W2100900404 cites W2003940624 @default.
• W2100900404 cites W2006449590 @default.
• W2100900404 cites W2015129765 @default.
• W2100900404 cites W2028109353 @default.
• W2100900404 cites W2033817976 @default.
• W2100900404 cites W2040611554 @default.
• W2100900404 cites W2042921323 @default.
• W2100900404 cites W2043617798 @default.
• W2100900404 cites W2047994580 @default.
• W2100900404 cites W2056823054 @default.
• W2100900404 cites W2067389682 @default.
• W2100900404 cites W2073106992 @default.
• W2100900404 cites W2084734831 @default.
• W2100900404 cites W2086790663 @default.
• W2100900404 cites W2092058842 @default.
• W2100900404 cites W2100954321 @default.
• W2100900404 cites W2106251845 @default.
• W2100900404 cites W2111305451 @default.
• W2100900404 cites W2115701574 @default.
• W2100900404 cites W2141786433 @default.
• W2100900404 cites W2164010163 @default.
• W2100900404 cites W2322995926 @default.
• W2100900404 doi "https://doi.org/10.1074/jbc.m110.163295" @default.
• W2100900404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3060470" @default.
• W2100900404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21262974" @default.
• W2100900404 hasPublicationYear "2011" @default.
• W2100900404 type Work @default.
• W2100900404 sameAs 2100900404 @default.
• W2100900404 citedByCount "39" @default.
• W2100900404 countsByYear W21009004042012 @default.
• W2100900404 countsByYear W21009004042013 @default.
• W2100900404 countsByYear W21009004042014 @default.
• W2100900404 countsByYear W21009004042015 @default.
• W2100900404 countsByYear W21009004042016 @default.
• W2100900404 countsByYear W21009004042017 @default.
• W2100900404 countsByYear W21009004042018 @default.
• W2100900404 countsByYear W21009004042019 @default.
• W2100900404 countsByYear W21009004042020 @default.
• W2100900404 countsByYear W21009004042021 @default.
• W2100900404 countsByYear W21009004042022 @default.
• W2100900404 countsByYear W21009004042023 @default.
• W2100900404 crossrefType "journal-article" @default.
• W2100900404 hasAuthorship W2100900404A5003682134 @default.
• W2100900404 hasAuthorship W2100900404A5005081854 @default.
• W2100900404 hasAuthorship W2100900404A5008624768 @default.
• W2100900404 hasAuthorship W2100900404A5018443439 @default.
• W2100900404 hasAuthorship W2100900404A5030810562 @default.
• W2100900404 hasAuthorship W2100900404A5032297429 @default.
• W2100900404 hasAuthorship W2100900404A5039503085 @default.
• W2100900404 hasAuthorship W2100900404A5040670147 @default.
• W2100900404 hasAuthorship W2100900404A5055318160 @default.
• W2100900404 hasAuthorship W2100900404A5061765669 @default.
• W2100900404 hasAuthorship W2100900404A5063575006 @default.
• W2100900404 hasBestOaLocation W21009004041 @default.
• W2100900404 hasConcept C11960822 @default.
• W2100900404 hasConcept C142724271 @default.
• W2100900404 hasConcept C153911025 @default.
• W2100900404 hasConcept C170493617 @default.
• W2100900404 hasConcept C178666793 @default.
• W2100900404 hasConcept C184235292 @default.
• W2100900404 hasConcept C185592680 @default.
• W2100900404 hasConcept C2776256026 @default.
• W2100900404 hasConcept C2779251935 @default.
• W2100900404 hasConcept C2779438470 @default.
• W2100900404 hasConcept C2780429522 @default.
• W2100900404 hasConcept C502942594 @default.
• W2100900404 hasConcept C55493867 @default.
• W2100900404 hasConcept C62478195 @default.
• W2100900404 hasConcept C71924100 @default.
• W2100900404 hasConcept C86803240 @default.
• W2100900404 hasConcept C95444343 @default.
• W2100900404 hasConceptScore W2100900404C11960822 @default.

• next