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- W2100900425 abstract "Three experiments explored the critical period associated with the neonatal organization of aggression by androgen in female mice. The first varied the dosage and time at which testosterone propionate was given neonatally and assessed the results by wound counts following chronic grouping in adulthood. A single injection of 400 μg TP at the time of birth was maximally effective in organizing aggressive behavior while 100 μg given at that time was less effective. An injection of 100 μg given at 36 hr postbirth was ineffective, while the effectiveness of 400 μg was lost by 48 hr. A single injection of 600 μg given at 48 hr, nevertheless, resulted in some fighting when females were grouped as adults. In the second experiment it was found that uptake of radiolabeled testosterone by several brain areas declined significantly from Day 0 to Day 12 of life. Thus the two experiments showed that as neonatal age increases an increasing amount of exogenous testosterone is necessary to organize aggressive behavior and, secondly, there is a decreasing uptake of testosterone by the brain with increasing age when uptake is measured as DPM/mg tissue weight. Adjustment of uptake values for DNA content in the third experiment altered the pattern of uptake and indicates the need for caution in interpreting hormone uptake data." @default.
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- W2100900425 date "1972-03-01" @default.
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- W2100900425 title "Neonatal organization of aggression in mice: Correlation of critical period with uptake of hormone*1" @default.
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- W2100900425 doi "https://doi.org/10.1016/0018-506x(72)90002-5" @default.
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