FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100913679> ?p ?o ?g. }

• W2100913679 endingPage "1609" @default.
• W2100913679 startingPage "1599" @default.
• W2100913679 abstract "Garlic constituent diallyl trisulfide (DATS) inhibits growth of cancer cells in vitro and in vivo by causing apoptosis, but the sequence of events leading to cell death is not fully understood. We now show that DATS treatment triggers mitochondria-mediated apoptosis program in human prostate cancer cells (LNCaP, LNCaP-C81, LNCaP-C4-2) irrespective of their androgen responsiveness. Interestingly, a normal prostate epithelial cell line (PrEC) is significantly more resistant to apoptosis induction by DATS compared with prostate cancer cells. The DATS-induced apoptosis in LNCaP cells correlated with the collapse of mitochondrial membrane potential, modest increase in protein level of Bak, and down-regulation of Bcl-2 and Bcl-xL protein levels. The DATS-induced apoptosis was significantly attenuated by knockdown of Bax and Bak proteins, but not by ectopic expression of either Bcl-2 or Bcl-xL. The DATS treatment caused generation of reactive oxygen species (ROS) in LNCaP cells, but not in PrEC, which was attenuated by pretreatment with antioxidant N-acetylcysteine. The N-acetylcysteine pretreatment conferred significant protection against DATS-mediated disruption of the mitochondrial membrane potential and apoptosis. In conclusion, the present study reveals that the mitochondria-mediated cell death by DATS is associated with ROS generation and regulated by Bax/Bak but independent of Bcl-2 or Bcl-xL." @default.
• W2100913679 created "2016-06-24" @default.
• W2100913679 creator A5016046232 @default.
• W2100913679 creator A5022304953 @default.
• W2100913679 creator A5026243543 @default.
• W2100913679 creator A5035350094 @default.
• W2100913679 creator A5047180423 @default.
• W2100913679 creator A5064478020 @default.
• W2100913679 creator A5072838238 @default.
• W2100913679 creator A5084819547 @default.
• W2100913679 creator A5058113641 @default.
• W2100913679 date "2007-05-01" @default.
• W2100913679 modified "2023-10-16" @default.
• W2100913679 title "Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak" @default.
• W2100913679 cites W1584378357 @default.
• W2100913679 cites W170725958 @default.
• W2100913679 cites W1909048318 @default.
• W2100913679 cites W1975483746 @default.
• W2100913679 cites W1982978735 @default.
• W2100913679 cites W1983967149 @default.
• W2100913679 cites W1984547206 @default.
• W2100913679 cites W1996389707 @default.
• W2100913679 cites W1999068029 @default.
• W2100913679 cites W2001471842 @default.
• W2100913679 cites W2002189255 @default.
• W2100913679 cites W2013091489 @default.
• W2100913679 cites W2020316909 @default.
• W2100913679 cites W2020641997 @default.
• W2100913679 cites W2037543040 @default.
• W2100913679 cites W2056318894 @default.
• W2100913679 cites W2057584177 @default.
• W2100913679 cites W2061497413 @default.
• W2100913679 cites W2062440930 @default.
• W2100913679 cites W2067296905 @default.
• W2100913679 cites W2067963578 @default.
• W2100913679 cites W2075177133 @default.
• W2100913679 cites W2075226068 @default.
• W2100913679 cites W2077270970 @default.
• W2100913679 cites W2081342061 @default.
• W2100913679 cites W2081963757 @default.
• W2100913679 cites W2086497168 @default.
• W2100913679 cites W2099594535 @default.
• W2100913679 cites W2101277805 @default.
• W2100913679 cites W2106241058 @default.
• W2100913679 cites W2113145328 @default.
• W2100913679 cites W2113170487 @default.
• W2100913679 cites W2114701464 @default.
• W2100913679 cites W2124221273 @default.
• W2100913679 cites W2130039362 @default.
• W2100913679 cites W2134979684 @default.
• W2100913679 cites W2135116050 @default.
• W2100913679 cites W2136407579 @default.
• W2100913679 cites W2138498649 @default.
• W2100913679 cites W2139148987 @default.
• W2100913679 cites W2142425696 @default.
• W2100913679 cites W2143175267 @default.
• W2100913679 cites W2156854438 @default.
• W2100913679 cites W2159369843 @default.
• W2100913679 cites W2168818034 @default.
• W2100913679 cites W2170586484 @default.
• W2100913679 cites W2172183972 @default.
• W2100913679 cites W2360318451 @default.
• W2100913679 doi "https://doi.org/10.1158/1535-7163.mct-06-0754" @default.
• W2100913679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2805823" @default.
• W2100913679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17513609" @default.
• W2100913679 hasPublicationYear "2007" @default.
• W2100913679 type Work @default.
• W2100913679 sameAs 2100913679 @default.
• W2100913679 citedByCount "111" @default.
• W2100913679 countsByYear W21009136792012 @default.
• W2100913679 countsByYear W21009136792013 @default.
• W2100913679 countsByYear W21009136792014 @default.
• W2100913679 countsByYear W21009136792015 @default.
• W2100913679 countsByYear W21009136792016 @default.
• W2100913679 countsByYear W21009136792017 @default.
• W2100913679 countsByYear W21009136792018 @default.
• W2100913679 countsByYear W21009136792020 @default.
• W2100913679 countsByYear W21009136792021 @default.
• W2100913679 countsByYear W21009136792022 @default.
• W2100913679 countsByYear W21009136792023 @default.
• W2100913679 crossrefType "journal-article" @default.
• W2100913679 hasAuthorship W2100913679A5016046232 @default.
• W2100913679 hasAuthorship W2100913679A5022304953 @default.
• W2100913679 hasAuthorship W2100913679A5026243543 @default.
• W2100913679 hasAuthorship W2100913679A5035350094 @default.
• W2100913679 hasAuthorship W2100913679A5047180423 @default.
• W2100913679 hasAuthorship W2100913679A5058113641 @default.
• W2100913679 hasAuthorship W2100913679A5064478020 @default.
• W2100913679 hasAuthorship W2100913679A5072838238 @default.
• W2100913679 hasAuthorship W2100913679A5084819547 @default.
• W2100913679 hasBestOaLocation W21009136791 @default.
• W2100913679 hasConcept C121608353 @default.
• W2100913679 hasConcept C153911025 @default.
• W2100913679 hasConcept C185592680 @default.
• W2100913679 hasConcept C190283241 @default.
• W2100913679 hasConcept C2779723316 @default.
• W2100913679 hasConcept C2780192828 @default.
• W2100913679 hasConcept C2781220098 @default.

• next