FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100917967> ?p ?o ?g. }

• W2100917967 abstract "Circulating blood contact with the surfaces of non-thromboresistant cardiopulmonary bypass (CPB) circuits induces several harmful inflammatory and hematological effects. Hussaini and colleagues in an effort to develop a more biocompatible CPB circuit that reduces inflammation, thrombogenesis and end-organ injury tested a thromboresistant CPB circuit using a heparin-bonded circuit (HBC) (1). The use of HBC is controversial as prior human studies using HBC have reported modest reductions at best in complement activation (2) as well as postoperative length of stay and end-organ injury (3). However, these studies have been criticized for a possible selection basis. Nonetheless, the use of these circuits is associated with reduced circulating complement (4, 5), interleukin-6 (5) and activated granulocytes (4, 6). The authors of this current study hypothesized that the outcomes using HBC may be improved by: 1) maintenance of a higher hematocrit (Hct) > 25%; 2) use of a closed perfusion system to eliminate the blood-gas interface (another site of foreign surface exposure); and 3) systemic normothermia. To study this, the authors compared HBC to conventional CPB (non-heparin-bonded circuits; NHB) in a porcine model (1).Anticoagulation as measured by ACT was achieved in both groups, although supratherapeutic levels were often achieved in the NHB group during CPB. Intraoperative hemodynamics were similar, and blood loss was higher in the NHB group as might be expected given the higher ACT (347.8 ± 79.3 ml vs. 214.1 ± 34.5 ml). In addition, thrombin anti-thrombin complex (TATIII) formation occurred more rapidly and remained elevated in the NHB group compared to the HBC group. Alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, creatine phosphokinase and gamma-glutamyl transferase levels were also higher in the NHB group, and postoperative leukocyte and platelet counts were significantly lower. As might be expected, animals in the HBC group required 51% less heparin and 61% less protamine than in the NHB group. Microscopically, the arterial filters of the NHB circuits were clogged by activated leukocytes, red blood cells and platelets while the filters from HBC circuits were free of debris.Like all studies, there are several unanswered questions. First, the modified perfusion strategy changed several variables. This begs the question: which changes from conventional CPB are responsible for the observed effects—the increased hematocrit, normothermia, the HBC? The use of normothermia may be especially concerning to some surgeons since hypoperfusion may still occur while on CPB and hypothermia offers some end-organ protection. Finally, no cytokine levels were measured to further quantify the pro-inflammatory effects of these perfusion strategies. Nonetheless, these data suggest modification of conventional perfusion strategies may reduce CPB-associated inflammatory, immunologic and hematologic derangements. Further study is needed to identify the mechanisms the lead to authors’ observed results. Hopefully further mechanistic insight will lead to new perfusion strategies and circuits for patients." @default.
• W2100917967 created "2016-06-24" @default.
• W2100917967 creator A5008842860 @default.
• W2100917967 date "2010-10-01" @default.
• W2100917967 modified "2023-09-26" @default.
• W2100917967 title "Thromboresistant Cardiopulmonary Bypass Circuits: Room for Improvement?" @default.
• W2100917967 cites W1976356486 @default.
• W2100917967 cites W1992276483 @default.
• W2100917967 cites W2019203199 @default.
• W2100917967 cites W2077357590 @default.
• W2100917967 cites W2161535330 @default.
• W2100917967 cites W57471503 @default.
• W2100917967 cites W2552789747 @default.
• W2100917967 doi "https://doi.org/10.1016/j.jss.2010.02.032" @default.
• W2100917967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2920367" @default.
• W2100917967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20452618" @default.
• W2100917967 hasPublicationYear "2010" @default.
• W2100917967 type Work @default.
• W2100917967 sameAs 2100917967 @default.
• W2100917967 citedByCount "1" @default.
• W2100917967 crossrefType "journal-article" @default.
• W2100917967 hasAuthorship W2100917967A5008842860 @default.
• W2100917967 hasBestOaLocation W21009179672 @default.
• W2100917967 hasConcept C111684460 @default.
• W2100917967 hasConcept C126322002 @default.
• W2100917967 hasConcept C141071460 @default.
• W2100917967 hasConcept C146957229 @default.
• W2100917967 hasConcept C159654299 @default.
• W2100917967 hasConcept C203014093 @default.
• W2100917967 hasConcept C2777557582 @default.
• W2100917967 hasConcept C2778881276 @default.
• W2100917967 hasConcept C2780959883 @default.
• W2100917967 hasConcept C42219234 @default.
• W2100917967 hasConcept C71924100 @default.
• W2100917967 hasConcept C98274493 @default.
• W2100917967 hasConceptScore W2100917967C111684460 @default.
• W2100917967 hasConceptScore W2100917967C126322002 @default.
• W2100917967 hasConceptScore W2100917967C141071460 @default.
• W2100917967 hasConceptScore W2100917967C146957229 @default.
• W2100917967 hasConceptScore W2100917967C159654299 @default.
• W2100917967 hasConceptScore W2100917967C203014093 @default.
• W2100917967 hasConceptScore W2100917967C2777557582 @default.
• W2100917967 hasConceptScore W2100917967C2778881276 @default.
• W2100917967 hasConceptScore W2100917967C2780959883 @default.
• W2100917967 hasConceptScore W2100917967C42219234 @default.
• W2100917967 hasConceptScore W2100917967C71924100 @default.
• W2100917967 hasConceptScore W2100917967C98274493 @default.
• W2100917967 hasLocation W21009179671 @default.
• W2100917967 hasLocation W21009179672 @default.
• W2100917967 hasLocation W21009179673 @default.
• W2100917967 hasLocation W21009179674 @default.
• W2100917967 hasOpenAccess W2100917967 @default.
• W2100917967 hasPrimaryLocation W21009179671 @default.
• W2100917967 hasRelatedWork W147525296 @default.
• W2100917967 hasRelatedWork W1990893901 @default.
• W2100917967 hasRelatedWork W2010872669 @default.
• W2100917967 hasRelatedWork W2012508032 @default.
• W2100917967 hasRelatedWork W2016829775 @default.
• W2100917967 hasRelatedWork W2017392186 @default.
• W2100917967 hasRelatedWork W2019598380 @default.
• W2100917967 hasRelatedWork W2019900293 @default.
• W2100917967 hasRelatedWork W2039770532 @default.
• W2100917967 hasRelatedWork W204743721 @default.
• W2100917967 hasRelatedWork W2070640812 @default.
• W2100917967 hasRelatedWork W2073575752 @default.
• W2100917967 hasRelatedWork W2077785490 @default.
• W2100917967 hasRelatedWork W2103047609 @default.
• W2100917967 hasRelatedWork W2160361451 @default.
• W2100917967 hasRelatedWork W2217009991 @default.
• W2100917967 hasRelatedWork W2355493458 @default.
• W2100917967 hasRelatedWork W2463560166 @default.
• W2100917967 hasRelatedWork W266743177 @default.
• W2100917967 hasRelatedWork W3018244887 @default.
• W2100917967 isParatext "false" @default.
• W2100917967 isRetracted "false" @default.
• W2100917967 magId "2100917967" @default.
• W2100917967 workType "article" @default.