FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100918356> ?p ?o ?g. }

• W2100918356 endingPage "3076" @default.
• W2100918356 startingPage "3065" @default.
• W2100918356 abstract "ABSTRACT Autophagy is used by eukaryotes in bulk cellular material recycling and in immunity to intracellular pathogens. We evaluated the role of macrophage autophagy in the response to Cryptococcus neoformans and Candida albicans , two important opportunistic fungal pathogens. The autophagosome marker LC3 (microtubule-associated protein 1 light chain 3 alpha) was present in most macrophage vacuoles containing C. albicans . In contrast, LC3 was found in only a few vacuoles containing C. neoformans previously opsonized with antibody but never after complement-mediated phagocytosis. Disruption of host autophagy in vitro by RNA interference against ATG5 (autophagy-related 5) decreased the phagocytosis of C. albicans and the fungistatic activity of J774.16 macrophage-like cells against both fungi, independent of the opsonin used. ATG5-knockout bone marrow-derived macrophages (BMMs) also had decreased fungistatic activity against C. neoformans when activated. In contrast, nonactivated ATG5-knockout BMMs actually restricted C. neoformans growth more efficiently, suggesting that macrophage autophagy plays different roles against C. neoformans , depending on the macrophage type and activation. Interference with autophagy in J774.16 cells also decreased nonlytic exocytosis of C. neoformans , increased interleukin-6 secretion, and decreased gamma interferon-induced protein 10 secretion. Mice with a conditionally knocked out ATG5 gene in myeloid cells showed increased susceptibility to intravenous C. albicans infection. In contrast, these mice manifested no increased susceptibility to C. neoformans , as measured by survival, but had fewer alternatively activated macrophages and less inflammation in the lungs after intratracheal infection than control mice. These results demonstrate the complex roles of macrophage autophagy in restricting intracellular parasitism by fungi and reveal connections with nonlytic exocytosis, humoral immunity, and cytokine signaling." @default.
• W2100918356 created "2016-06-24" @default.
• W2100918356 creator A5001312410 @default.
• W2100918356 creator A5013018406 @default.
• W2100918356 creator A5018216109 @default.
• W2100918356 creator A5048739701 @default.
• W2100918356 creator A5049671422 @default.
• W2100918356 creator A5067616971 @default.
• W2100918356 creator A5075646920 @default.
• W2100918356 creator A5077902719 @default.
• W2100918356 date "2012-09-01" @default.
• W2100918356 modified "2023-10-16" @default.
• W2100918356 title "Macrophage Autophagy in Immunity to Cryptococcus neoformans and Candida albicans" @default.
• W2100918356 cites W132359770 @default.
• W2100918356 cites W1490724351 @default.
• W2100918356 cites W1498352402 @default.
• W2100918356 cites W1507976770 @default.
• W2100918356 cites W1547052876 @default.
• W2100918356 cites W1780295430 @default.
• W2100918356 cites W1959874120 @default.
• W2100918356 cites W1965368723 @default.
• W2100918356 cites W1977112775 @default.
• W2100918356 cites W1977767269 @default.
• W2100918356 cites W1979213765 @default.
• W2100918356 cites W1985478291 @default.
• W2100918356 cites W1988604605 @default.
• W2100918356 cites W1994823455 @default.
• W2100918356 cites W1997725738 @default.
• W2100918356 cites W2005002911 @default.
• W2100918356 cites W2009195610 @default.
• W2100918356 cites W2012120951 @default.
• W2100918356 cites W2012451546 @default.
• W2100918356 cites W2013686234 @default.
• W2100918356 cites W2021532580 @default.
• W2100918356 cites W2028536701 @default.
• W2100918356 cites W2036167259 @default.
• W2100918356 cites W2047329367 @default.
• W2100918356 cites W2062406170 @default.
• W2100918356 cites W2068790641 @default.
• W2100918356 cites W2069498930 @default.
• W2100918356 cites W2069635419 @default.
• W2100918356 cites W2071634550 @default.
• W2100918356 cites W2079046408 @default.
• W2100918356 cites W2079513681 @default.
• W2100918356 cites W2082614716 @default.
• W2100918356 cites W2086181643 @default.
• W2100918356 cites W2088140877 @default.
• W2100918356 cites W2092365029 @default.
• W2100918356 cites W2099001273 @default.
• W2100918356 cites W2102642516 @default.
• W2100918356 cites W2111715441 @default.
• W2100918356 cites W2126734055 @default.
• W2100918356 cites W2128537698 @default.
• W2100918356 cites W2129155212 @default.
• W2100918356 cites W2140535415 @default.
• W2100918356 cites W2144543496 @default.
• W2100918356 cites W2154604278 @default.
• W2100918356 cites W2159610521 @default.
• W2100918356 cites W2161234475 @default.
• W2100918356 cites W2162644900 @default.
• W2100918356 cites W2170907002 @default.
• W2100918356 cites W2321438510 @default.
• W2100918356 doi "https://doi.org/10.1128/iai.00358-12" @default.
• W2100918356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3418760" @default.
• W2100918356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22710871" @default.
• W2100918356 hasPublicationYear "2012" @default.
• W2100918356 type Work @default.
• W2100918356 sameAs 2100918356 @default.
• W2100918356 citedByCount "102" @default.
• W2100918356 countsByYear W21009183562012 @default.
• W2100918356 countsByYear W21009183562013 @default.
• W2100918356 countsByYear W21009183562014 @default.
• W2100918356 countsByYear W21009183562015 @default.
• W2100918356 countsByYear W21009183562016 @default.
• W2100918356 countsByYear W21009183562017 @default.
• W2100918356 countsByYear W21009183562018 @default.
• W2100918356 countsByYear W21009183562019 @default.
• W2100918356 countsByYear W21009183562020 @default.
• W2100918356 countsByYear W21009183562021 @default.
• W2100918356 countsByYear W21009183562022 @default.
• W2100918356 countsByYear W21009183562023 @default.
• W2100918356 crossrefType "journal-article" @default.
• W2100918356 hasAuthorship W2100918356A5001312410 @default.
• W2100918356 hasAuthorship W2100918356A5013018406 @default.
• W2100918356 hasAuthorship W2100918356A5018216109 @default.
• W2100918356 hasAuthorship W2100918356A5048739701 @default.
• W2100918356 hasAuthorship W2100918356A5049671422 @default.
• W2100918356 hasAuthorship W2100918356A5067616971 @default.
• W2100918356 hasAuthorship W2100918356A5075646920 @default.
• W2100918356 hasAuthorship W2100918356A5077902719 @default.
• W2100918356 hasBestOaLocation W21009183561 @default.
• W2100918356 hasConcept C102568950 @default.
• W2100918356 hasConcept C145081991 @default.
• W2100918356 hasConcept C160448771 @default.
• W2100918356 hasConcept C161478664 @default.
• W2100918356 hasConcept C190062978 @default.
• W2100918356 hasConcept C190283241 @default.
• W2100918356 hasConcept C202751555 @default.

• next