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- W2100921663 abstract "A nontoxic, iodoacetamide-modified cobratoxin derivative (CAM-NTX) induced resistance to experimental allergic encephalomyelitis (EAE) in guinea pigs. Resistance was retained after trypsin digestion and shown to reside in N-terminal and central peptides of CAM-NTX. A similarly modified protein cardiotoxin (CAM-CTX), representative of proteins homologous with cobratoxin, was not immunosuppressive. Depressed clinical symptoms in EAE-resistant animals correlated with reduced lymphocytic infiltration of the brain. Antibody to myelin basic protein (MBP) was reduced in immunosuppressed animals. The immunoinhibitory determinants in CAM-NTX may mimic immune response suppressor proteins (SIRS-alpha 7) and the EAE-resistance region of MBP." @default.
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- W2100921663 date "1999-01-01" @default.
- W2100921663 modified "2023-10-11" @default.
- W2100921663 title "Sequence Determinants of Modified Cobra Venom Neurotoxin Which Induce Immune Resistance to Experimental Allergic Encephalomyelitis: Molecular Mechans for Immunologic Action" @default.
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- W2100921663 doi "https://doi.org/10.3109/08923979909007122" @default.
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