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• W2100930110 abstract "The burden of coronary artery disease (CAD) remains high across Europe and the rest of the world. CAD continues to be the main cause of death and a major cause of morbidity and loss of quality of life. The decline in age-standardized mortality rates and in incidence of CAD in many countries illustrates the potential for prevention of premature deaths and for prolonging life expectancy. New therapeutic options for prevention and treatment of CAD have resulted in an increasing number of patients who survive a cardiovascular event; in developed countries the burden has shifted from the middle-aged to the elderly and the prevalence of CAD increases exponentially with aging. CAD is a leading public health problem accounting for a significant proportion of total societal costs and representing 27% of total cardiovascular disease costs. Together with cerebrovascular diseases, CAD accounts for 64% of all cardiovascular deaths. There are a number of lifestyle changes that can be implemented to improve the prognosis of patients with stable CAD, including smoking cessation, adoption of a Mediterranean diet, body weight reduction, and increased physical activity. Concomitant risk factors such as diabetes, dyslipidaemia, and hypertension should be managed aggressively. Current treatment options for stable CAD involve a two-pronged approach combining antianginal treatment to improve symptoms and quality of life along with a cardioprotective treatment to prevent cardiovascular events. Optimal medical treatment should be the initial management approach in the majority of patients with stable CAD, even if extensive and multi-vessel atherosclerosis is involved. A large body of evidence suggests that high resting heart rate (HR) is a potential risk factor for mortality and morbidity in various populations, including patients with CAD. Experimental evidence indicates that high HR plays a role in endothelial dysfunction and atherosclerosis progression. An HR ≥70 b.p.m. is associated with an increased cardiovascular risk. Ongoing randomized trials are evaluating the role of selective HR reduction in improving cardiovascular outcomes. These trial data will be complemented by CLARIFY, a large-scale international registry of outpatients with stable CAD which will analyse not only the baseline characteristics and management practices but will also capture all suspected important determinants of outcomes including resting HR." @default.
• W2100930110 created "2016-06-24" @default.
• W2100930110 creator A5049309607 @default.
• W2100930110 date "2010-08-01" @default.
• W2100930110 modified "2023-10-06" @default.
• W2100930110 title "Coronary artery disease in 2010" @default.
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• W2100930110 doi "https://doi.org/10.1093/eurheartj/suq014" @default.
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