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• W2100933640 abstract "Voltage-gated potassium channels are composed of four subunits. Voltage-dependent activation of these channels consists of a depolarization-triggered series of charge-carrying steps that occur in each subunit. These major charge-carrying steps are followed by cooperative step(s) that lead to channel opening. Unlike the late cooperative steps, the major charge-carrying steps have been proposed to occur independently in each of the channel subunits. In this paper, we examine this further. We showed earlier that the two major charge-carrying steps are associated with two sequential outward transmembrane movements of the charged S4 segment. We now use voltage clamp fluorometry to monitor these S4 movements in individual subunits of heterotetrameric channels. In this way, we estimate the influence of one subunit's S4 movement on another's when the energetics of their transmembrane movements differ. Our results show that the first S4 movement occurs independently in each subunit, while the second occurs cooperatively. At least part of the cooperativity appears to be intrinsic to the second S4 charge-carrying rearrangement. Such cooperativity in gating of voltage-dependent channels has great physiological relevance since it can affect both action potential threshold and rate of propagation." @default.
• W2100933640 created "2016-06-24" @default.
• W2100933640 creator A5081378606 @default.
• W2100933640 creator A5084445874 @default.
• W2100933640 date "2000-02-14" @default.
• W2100933640 modified "2023-10-02" @default.
• W2100933640 title "Independence and Cooperativity in Rearrangements of a Potassium Channel Voltage Sensor Revealed by Single Subunit Fluorescence" @default.
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• W2100933640 doi "https://doi.org/10.1085/jgp.115.3.257" @default.
• W2100933640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2217208" @default.
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