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- W2100979233 abstract "Whether coat proteins play a widespread role in endocytic recycling remains unclear. We find that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings, stimulation-dependent recycling of integrin that is critical for cell migration and insulin-stimulated recycling of glucose transporter type 4 (Glut4), which is required for glucose homeostasis. These findings not only advance a basic understanding of an early mechanistic step in endocytic recycling but also shed key mechanistic insights into major physiological events for which this transport plays a critical role." @default.
- W2100979233 created "2016-06-24" @default.
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- W2100979233 date "2007-07-30" @default.
- W2100979233 modified "2023-10-03" @default.
- W2100979233 title "An ACAP1-containing clathrin coat complex for endocytic recycling" @default.
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- W2100979233 doi "https://doi.org/10.1083/jcb.200608033" @default.
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