FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100990262> ?p ?o ?g. }

• W2100990262 endingPage "298" @default.
• W2100990262 startingPage "293" @default.
• W2100990262 abstract "Okadaic acid (OA) is a major toxin involved in diarrhetic shellfish poisoning in humans and has been shown to be both a potent tumor promoter in rodent skin and stomach and an inhibitor of serine/threonine protein phosphatases, specifically PP1 and PP2A. The research on the genotoxic potential of OA amounts to only a few studies, which give conflicting results. In order to evaluate the ability of OA to induce DNA damage, the cytokinesis-block micronucleus assay was performed in the CHO-K1 cell line. A statistically significant induction of micronuclei without strong cytotoxicity was obtained after a 24 h treatment with 20 (approximately 5-fold) and 30 nM (approximately 10-fold) OA. Then, in order to discriminate between a clastogenic or aneugenic effect of OA, the micronucleus assay was carried out in combination with fluorescence in situ hybridization (FISH) using a (TTAGGG)(n) DNA probe for centromere detection. FISH analysis showed that OA mainly induced centromere-positive micronuclei (68.9% induction with 20 nM OA and 77.0% with 30 nM). Therefore, OA can be considered aneugenic. Using the same assay, biotransformation of OA was studied after a 4 h treatment with and without metabolic activation. The results show that reactive metabolites of OA were generated with a significant increase in genotoxic potential. The relationship between the different components involved in the mitotic process and OA inhibition of protein phosphatase is also discussed." @default.
• W2100990262 created "2016-06-24" @default.
• W2100990262 creator A5027938813 @default.
• W2100990262 date "2003-05-01" @default.
• W2100990262 modified "2023-09-25" @default.
• W2100990262 title "Aneugenic potential of okadaic acid revealed by the micronucleus assay combined with the FISH technique in CHO-K1 cells" @default.
• W2100990262 cites W156224539 @default.
• W2100990262 cites W1943150066 @default.
• W2100990262 cites W1960573418 @default.
• W2100990262 cites W1963301059 @default.
• W2100990262 cites W1974434422 @default.
• W2100990262 cites W1976199579 @default.
• W2100990262 cites W1976217600 @default.
• W2100990262 cites W1981243135 @default.
• W2100990262 cites W1984972991 @default.
• W2100990262 cites W1987584703 @default.
• W2100990262 cites W1997790641 @default.
• W2100990262 cites W2000400406 @default.
• W2100990262 cites W2002904890 @default.
• W2100990262 cites W2022512166 @default.
• W2100990262 cites W2022729618 @default.
• W2100990262 cites W2024264346 @default.
• W2100990262 cites W2034211035 @default.
• W2100990262 cites W2035386950 @default.
• W2100990262 cites W2037309885 @default.
• W2100990262 cites W2040854485 @default.
• W2100990262 cites W2040969783 @default.
• W2100990262 cites W2042667650 @default.
• W2100990262 cites W2045231285 @default.
• W2100990262 cites W2048721312 @default.
• W2100990262 cites W2052677449 @default.
• W2100990262 cites W2056204961 @default.
• W2100990262 cites W2057779252 @default.
• W2100990262 cites W2059602806 @default.
• W2100990262 cites W2060309803 @default.
• W2100990262 cites W2067668969 @default.
• W2100990262 cites W2070403888 @default.
• W2100990262 cites W2079635294 @default.
• W2100990262 cites W2081783929 @default.
• W2100990262 cites W2082232487 @default.
• W2100990262 cites W2093310181 @default.
• W2100990262 cites W2095707243 @default.
• W2100990262 cites W2096985970 @default.
• W2100990262 cites W2098883242 @default.
• W2100990262 cites W2104063044 @default.
• W2100990262 cites W2105228917 @default.
• W2100990262 cites W2112560233 @default.
• W2100990262 cites W2112854488 @default.
• W2100990262 cites W2133125965 @default.
• W2100990262 cites W2144778448 @default.
• W2100990262 cites W2149730011 @default.
• W2100990262 cites W2154771600 @default.
• W2100990262 cites W2164898699 @default.
• W2100990262 cites W2164972698 @default.
• W2100990262 cites W2168220558 @default.
• W2100990262 cites W2168788736 @default.
• W2100990262 cites W2178456244 @default.
• W2100990262 cites W2328983208 @default.
• W2100990262 cites W2344538679 @default.
• W2100990262 cites W2399616656 @default.
• W2100990262 cites W2407026676 @default.
• W2100990262 doi "https://doi.org/10.1093/mutage/18.3.293" @default.
• W2100990262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12714697" @default.
• W2100990262 hasPublicationYear "2003" @default.
• W2100990262 type Work @default.
• W2100990262 sameAs 2100990262 @default.
• W2100990262 citedByCount "43" @default.
• W2100990262 countsByYear W21009902622012 @default.
• W2100990262 countsByYear W21009902622013 @default.
• W2100990262 countsByYear W21009902622014 @default.
• W2100990262 countsByYear W21009902622015 @default.
• W2100990262 countsByYear W21009902622017 @default.
• W2100990262 countsByYear W21009902622019 @default.
• W2100990262 countsByYear W21009902622020 @default.
• W2100990262 crossrefType "journal-article" @default.
• W2100990262 hasAuthorship W2100990262A5027938813 @default.
• W2100990262 hasConcept C141710004 @default.
• W2100990262 hasConcept C143425029 @default.
• W2100990262 hasConcept C153911025 @default.
• W2100990262 hasConcept C178666793 @default.
• W2100990262 hasConcept C178790620 @default.
• W2100990262 hasConcept C181199279 @default.
• W2100990262 hasConcept C185592680 @default.
• W2100990262 hasConcept C2776953658 @default.
• W2100990262 hasConcept C2778959862 @default.
• W2100990262 hasConcept C29730261 @default.
• W2100990262 hasConcept C36681516 @default.
• W2100990262 hasConcept C45080847 @default.
• W2100990262 hasConcept C552990157 @default.
• W2100990262 hasConcept C55493867 @default.
• W2100990262 hasConcept C86803240 @default.
• W2100990262 hasConceptScore W2100990262C141710004 @default.
• W2100990262 hasConceptScore W2100990262C143425029 @default.
• W2100990262 hasConceptScore W2100990262C153911025 @default.
• W2100990262 hasConceptScore W2100990262C178666793 @default.
• W2100990262 hasConceptScore W2100990262C178790620 @default.
• W2100990262 hasConceptScore W2100990262C181199279 @default.
• W2100990262 hasConceptScore W2100990262C185592680 @default.

• next