FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101014673> ?p ?o ?g. }

• W2101014673 endingPage "F34" @default.
• W2101014673 startingPage "F20" @default.
• W2101014673 abstract "The epithelial tight junction (TJ) has three major functions. As a “gate,” it serves as a regulatory barrier separating and maintaining biological fluid compartments of different composition. As a “fence,” it generates and maintains the apicobasal polarity of cells that form the confluent epithelium. Finally, the TJ proteins form a trafficking and signaling platform that regulates cell growth, proliferation, differentiation, and dedifferentiation. Six examples are selected that illustrate the emerging link between TJ dysfunction and kidney disease. First, the glomerular slit diaphragm (GSD) is evolved, in part, from the TJ and, on maturation, exhibits all three functions of the TJ. GSD dysfunction leads to proteinuria and, in some instances, podocyte dedifferentiation and proliferation. Second, accumulating evidence supports epithelial-mesenchymal transformation (EMT) as a major player in renal fibrosis, the final common pathway that leads to end-stage renal failure. EMT is characterized by a loss of cell-cell contact and apicobasal polarity, which are hallmarks of TJ dysfunction. Third, in autosomal dominant polycystic kidney disease, mutations of the polycystins may disrupt their known interactions with the apical junction complex, of which the TJ is a major component. This can lead to disturbances in epithelial polarity regulation with consequent abnormal tubulogenesis and cyst formation. Fourth, evidence for epithelial barrier and polarity dysregulation in the pathogenesis of ischemic acute renal failure will be summarized. Fifth, the association between mutations of paracellin-1, the first TJ channel identified, and clinical disorders of magnesium and calcium wasting and bovine renal fibrosis will be used to highlight an integral TJ protein that can serve multiple TJ functions. Finally, the role of WNK4 protein kinase in shunting chloride across the TJ of the distal nephron will be addressed." @default.
• W2101014673 created "2016-06-24" @default.
• W2101014673 creator A5028791648 @default.
• W2101014673 creator A5031814335 @default.
• W2101014673 creator A5059319154 @default.
• W2101014673 date "2006-01-01" @default.
• W2101014673 modified "2023-10-15" @default.
• W2101014673 title "Tight junction biology and kidney dysfunction" @default.
• W2101014673 cites W1225109155 @default.
• W2101014673 cites W1488993056 @default.
• W2101014673 cites W1534220125 @default.
• W2101014673 cites W1554042779 @default.
• W2101014673 cites W1589010135 @default.
• W2101014673 cites W1744742580 @default.
• W2101014673 cites W1964177773 @default.
• W2101014673 cites W1965392456 @default.
• W2101014673 cites W1968707758 @default.
• W2101014673 cites W1970258604 @default.
• W2101014673 cites W1971171800 @default.
• W2101014673 cites W1972419229 @default.
• W2101014673 cites W1974584764 @default.
• W2101014673 cites W1974587800 @default.
• W2101014673 cites W1974969464 @default.
• W2101014673 cites W1977658450 @default.
• W2101014673 cites W1978785485 @default.
• W2101014673 cites W1979970784 @default.
• W2101014673 cites W1985195015 @default.
• W2101014673 cites W1985337325 @default.
• W2101014673 cites W1986340915 @default.
• W2101014673 cites W1987704449 @default.
• W2101014673 cites W1988319136 @default.
• W2101014673 cites W1988501179 @default.
• W2101014673 cites W1989836067 @default.
• W2101014673 cites W1993033152 @default.
• W2101014673 cites W1996680498 @default.
• W2101014673 cites W1997196951 @default.
• W2101014673 cites W1997802716 @default.
• W2101014673 cites W1997868447 @default.
• W2101014673 cites W2005127084 @default.
• W2101014673 cites W2005993913 @default.
• W2101014673 cites W2007058758 @default.
• W2101014673 cites W2008434851 @default.
• W2101014673 cites W2008715388 @default.
• W2101014673 cites W2013002334 @default.
• W2101014673 cites W2013480667 @default.
• W2101014673 cites W2017231237 @default.
• W2101014673 cites W2018070639 @default.
• W2101014673 cites W2018457137 @default.
• W2101014673 cites W2021859563 @default.
• W2101014673 cites W2026087924 @default.
• W2101014673 cites W2026157746 @default.
• W2101014673 cites W2026265694 @default.
• W2101014673 cites W2026549297 @default.
• W2101014673 cites W2027151815 @default.
• W2101014673 cites W2028224423 @default.
• W2101014673 cites W2028919524 @default.
• W2101014673 cites W2031226622 @default.
• W2101014673 cites W2035034837 @default.
• W2101014673 cites W2038569449 @default.
• W2101014673 cites W2039356805 @default.
• W2101014673 cites W2040022930 @default.
• W2101014673 cites W2044814799 @default.
• W2101014673 cites W2047866696 @default.
• W2101014673 cites W2048686880 @default.
• W2101014673 cites W2050875396 @default.
• W2101014673 cites W2056106838 @default.
• W2101014673 cites W2056229530 @default.
• W2101014673 cites W2057282956 @default.
• W2101014673 cites W2058416613 @default.
• W2101014673 cites W2059957280 @default.
• W2101014673 cites W2065318125 @default.
• W2101014673 cites W2065919942 @default.
• W2101014673 cites W2065950525 @default.
• W2101014673 cites W2066401036 @default.
• W2101014673 cites W2067139290 @default.
• W2101014673 cites W2067256355 @default.
• W2101014673 cites W2067648338 @default.
• W2101014673 cites W2068907068 @default.
• W2101014673 cites W2069709653 @default.
• W2101014673 cites W2071233660 @default.
• W2101014673 cites W2080888904 @default.
• W2101014673 cites W2082719247 @default.
• W2101014673 cites W2082823773 @default.
• W2101014673 cites W2085622604 @default.
• W2101014673 cites W2086851567 @default.
• W2101014673 cites W2087367170 @default.
• W2101014673 cites W2087482733 @default.
• W2101014673 cites W2089209075 @default.
• W2101014673 cites W2090678693 @default.
• W2101014673 cites W2091760428 @default.
• W2101014673 cites W2092550529 @default.
• W2101014673 cites W2093401766 @default.
• W2101014673 cites W2095869636 @default.
• W2101014673 cites W2096502519 @default.
• W2101014673 cites W2096791952 @default.
• W2101014673 cites W2097258509 @default.
• W2101014673 cites W2097643484 @default.
• W2101014673 cites W2097722745 @default.

• next