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- W2101017316 abstract "Erythropoietin (EPO) is a 30.4 kDa glycoprotein produced by the kidney, and is mostly well-known for its physiological function in regulating red blood cell production in the bone marrow. Accumulating evidence, however, suggests that EPO has additional organ protective effects, which may be useful in the prevention or treatment of acute kidney injury. These protective mechanisms are multifactorial in nature and include inhibition of apoptotic cell death, stimulation of cellular regeneration, inhibition of deleterious pathways, and promotion of recovery.In this article, we review the physiology of EPO, assess previous work that supports the role of EPO as a general tissue protective agent, and explain the mechanisms by which it may achieve this tissue protective effect. We then focus on experimental and clinical data that suggest that EPO has a kidney protective effect." @default.
- W2101017316 created "2016-06-24" @default.
- W2101017316 creator A5067025752 @default.
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- W2101017316 date "2011-03-21" @default.
- W2101017316 modified "2023-10-16" @default.
- W2101017316 title "Erythropoietin (EPO) in acute kidney injury" @default.
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- W2101017316 doi "https://doi.org/10.1186/2110-5820-1-3" @default.
- W2101017316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3159901" @default.
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