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- W2101025339 abstract "How to predict phenotypic development in a changing environment from the genotype of complex organisms is one of the most important and challenging questions we face in modern biology. This challenge can be addressed through establishing a framework that identifies and maps the mechanistic basis of the processes from genotype to phenotype. The central rationale of this framework is based on the genetic, developmental and regulatory dissection of phenotypic changes in response to different environments. First, a phenotype is genetically complex because of the involvement of many genes that display pervasive interactions with other genes and with environmental factors. Second, the formation of any phenotype involves a series of developmental events and biological alterations that entail cell growth, differentiation and morphogenesis. Third, DNA polymorphisms affect variation in a phenotype by perturbing transcripts, metabolites and proteins in transcriptional and regulatory networks. In this editorial, I attempt to provide a big picture of each of these three aspects on phenotypic dissection. The genotype-phenotype prediction can be enabled by integrating mathematical models for developmental processes from morphogenesis to pattern formation as well as for transcript, protein and metabolite abundance affecting high-order phenotypes through a series of biochemical steps." @default.
- W2101025339 created "2016-06-24" @default.
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- W2101025339 date "2012-01-01" @default.
- W2101025339 modified "2023-09-27" @default.
- W2101025339 title "Predicting the Genotype-Phenotype Map of Complex Traits" @default.
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- W2101025339 doi "https://doi.org/10.4172/2155-6180.1000e109" @default.
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