Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101050524> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2101050524 endingPage "4913" @default.
- W2101050524 startingPage "4905" @default.
- W2101050524 abstract "When assessing the effectiveness of a hormonal method of fertility control in men, the classical approach used for the assessment of hormonal contraceptives in women, by estimating the pregnancy rate or using a life-table analysis for the time to pregnancy, is difficult to apply in a clinical development program. The main reasons are the dissociation of the treated unit, i.e. the man, and the observed unit, i.e. his female partner, the high variability in the frequency of male intercourse, the logistical cost and ethical concerns related to the monitoring of the trial. A reasonable surrogate endpoint of the definite endpoint time to pregnancy is sperm count. In addition to the avoidance of the mentioned problems, trials that compare different treatments are possible with reasonable sample sizes, and study duration can be shorter. However, current products do not suppress sperm production to 100 per cent in all men and the sperm count is only observed with measurement error. Complete azoospermia might not be necessary in order to achieve an acceptable failure rate compared with other forms of male fertility control. Therefore, the use of sperm count as a surrogate endpoint must rely on the results of a previous trial in which both the definitive- and surrogate-endpoint results were assessed. The paper discusses different estimation functions of the mean pregnancy rate (corresponding to the cumulative hazard) that are based on the results of sperm count trial and a previous trial in which both sperm count and time to pregnancy were assessed, as well as the underlying assumptions. Sample size estimations are given for pregnancy rate estimation with a given precision." @default.
- W2101050524 created "2016-06-24" @default.
- W2101050524 creator A5008233479 @default.
- W2101050524 creator A5055773399 @default.
- W2101050524 date "2007-07-05" @default.
- W2101050524 modified "2023-09-26" @default.
- W2101050524 title "Sperm count as a surrogate endpoint for male fertility control" @default.
- W2101050524 cites W2011453559 @default.
- W2101050524 cites W2114939854 @default.
- W2101050524 cites W2122538948 @default.
- W2101050524 cites W2155949904 @default.
- W2101050524 cites W2162272956 @default.
- W2101050524 cites W4244334045 @default.
- W2101050524 cites W4250222852 @default.
- W2101050524 cites W4293007148 @default.
- W2101050524 doi "https://doi.org/10.1002/sim.2967" @default.
- W2101050524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17611956" @default.
- W2101050524 hasPublicationYear "2007" @default.
- W2101050524 type Work @default.
- W2101050524 sameAs 2101050524 @default.
- W2101050524 citedByCount "3" @default.
- W2101050524 countsByYear W21010505242016 @default.
- W2101050524 countsByYear W21010505242022 @default.
- W2101050524 crossrefType "journal-article" @default.
- W2101050524 hasAuthorship W2101050524A5008233479 @default.
- W2101050524 hasAuthorship W2101050524A5055773399 @default.
- W2101050524 hasConcept C126322002 @default.
- W2101050524 hasConcept C131872663 @default.
- W2101050524 hasConcept C141341695 @default.
- W2101050524 hasConcept C16685009 @default.
- W2101050524 hasConcept C203092338 @default.
- W2101050524 hasConcept C2776537878 @default.
- W2101050524 hasConcept C2777420699 @default.
- W2101050524 hasConcept C2777688143 @default.
- W2101050524 hasConcept C2779234561 @default.
- W2101050524 hasConcept C2781087480 @default.
- W2101050524 hasConcept C2908647359 @default.
- W2101050524 hasConcept C29456083 @default.
- W2101050524 hasConcept C518429986 @default.
- W2101050524 hasConcept C535046627 @default.
- W2101050524 hasConcept C54355233 @default.
- W2101050524 hasConcept C71924100 @default.
- W2101050524 hasConcept C86803240 @default.
- W2101050524 hasConcept C99454951 @default.
- W2101050524 hasConceptScore W2101050524C126322002 @default.
- W2101050524 hasConceptScore W2101050524C131872663 @default.
- W2101050524 hasConceptScore W2101050524C141341695 @default.
- W2101050524 hasConceptScore W2101050524C16685009 @default.
- W2101050524 hasConceptScore W2101050524C203092338 @default.
- W2101050524 hasConceptScore W2101050524C2776537878 @default.
- W2101050524 hasConceptScore W2101050524C2777420699 @default.
- W2101050524 hasConceptScore W2101050524C2777688143 @default.
- W2101050524 hasConceptScore W2101050524C2779234561 @default.
- W2101050524 hasConceptScore W2101050524C2781087480 @default.
- W2101050524 hasConceptScore W2101050524C2908647359 @default.
- W2101050524 hasConceptScore W2101050524C29456083 @default.
- W2101050524 hasConceptScore W2101050524C518429986 @default.
- W2101050524 hasConceptScore W2101050524C535046627 @default.
- W2101050524 hasConceptScore W2101050524C54355233 @default.
- W2101050524 hasConceptScore W2101050524C71924100 @default.
- W2101050524 hasConceptScore W2101050524C86803240 @default.
- W2101050524 hasConceptScore W2101050524C99454951 @default.
- W2101050524 hasIssue "27" @default.
- W2101050524 hasLocation W21010505241 @default.
- W2101050524 hasLocation W21010505242 @default.
- W2101050524 hasOpenAccess W2101050524 @default.
- W2101050524 hasPrimaryLocation W21010505241 @default.
- W2101050524 hasRelatedWork W1852785632 @default.
- W2101050524 hasRelatedWork W2044456805 @default.
- W2101050524 hasRelatedWork W2297790284 @default.
- W2101050524 hasRelatedWork W233786208 @default.
- W2101050524 hasRelatedWork W2391029172 @default.
- W2101050524 hasRelatedWork W2432228997 @default.
- W2101050524 hasRelatedWork W2442288397 @default.
- W2101050524 hasRelatedWork W3014433341 @default.
- W2101050524 hasRelatedWork W81882195 @default.
- W2101050524 hasRelatedWork W2973164954 @default.
- W2101050524 hasVolume "26" @default.
- W2101050524 isParatext "false" @default.
- W2101050524 isRetracted "false" @default.
- W2101050524 magId "2101050524" @default.
- W2101050524 workType "article" @default.