FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101070690> ?p ?o ?g. }

• W2101070690 endingPage "12" @default.
• W2101070690 startingPage "1" @default.
• W2101070690 abstract "Developmental endothelial locus-1 (Del-1) is an endothelial cell-secreted protein that limits the recruitment of neutrophils by antagonizing the interaction between the LFA-1 integrin on neutrophils and the intercellular adhesion molecule (ICAM)-1 on endothelial cells. Mice with genetic or age-associated Del-1 deficiency exhibit increased neutrophil infiltration in the periodontium resulting in inflammatory bone loss. Here we investigated additional novel mechanisms whereby Del-1 could interfere with neutrophil recruitment and inflammation. Treatment of human endothelial cells with Del-1 did not affect the expression of endothelial molecules involved in the leukocyte adhesion cascade (ICAM-1, VCAM-1, and E-selectin). Moreover, genetic or age-associated Del-1 deficiency did not significantly alter the expression of these adhesion molecules in the murine periodontium, further ruling out altered adhesion molecule expression as a mechanism whereby Del-1 regulates leukocyte recruitment. Strikingly, Del-1 inhibited ICAM-1-dependent chemokine release (CXCL2, CCL3) by neutrophils. Therefore, Del-1 could potentially suppress the amplification of inflammatory cell recruitment mediated through chemokine release by infiltrating neutrophils. Interestingly, Del-1 was itself regulated by inflammatory stimuli, which generally exerted opposite effects on adhesion molecule expression. The reciprocal regulation between Del-1 and inflammation may contribute to optimally balance the protective and the potentially harmful effects of inflammatory cell recruitment." @default.
• W2101070690 created "2016-06-24" @default.
• W2101070690 creator A5019049830 @default.
• W2101070690 creator A5031165760 @default.
• W2101070690 creator A5033614715 @default.
• W2101070690 creator A5043136018 @default.
• W2101070690 creator A5074199827 @default.
• W2101070690 creator A5084031628 @default.
• W2101070690 creator A5086672334 @default.
• W2101070690 date "2013-01-01" @default.
• W2101070690 modified "2023-10-16" @default.
• W2101070690 title "Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue" @default.
• W2101070690 cites W1639854378 @default.
• W2101070690 cites W1970283968 @default.
• W2101070690 cites W1973000903 @default.
• W2101070690 cites W1982702913 @default.
• W2101070690 cites W1990974422 @default.
• W2101070690 cites W1994080141 @default.
• W2101070690 cites W1994606929 @default.
• W2101070690 cites W2002438747 @default.
• W2101070690 cites W2016033094 @default.
• W2101070690 cites W2017987372 @default.
• W2101070690 cites W2035809865 @default.
• W2101070690 cites W2041431337 @default.
• W2101070690 cites W2066151306 @default.
• W2101070690 cites W2084800734 @default.
• W2101070690 cites W2090443712 @default.
• W2101070690 cites W2095594283 @default.
• W2101070690 cites W2108571057 @default.
• W2101070690 cites W2166769371 @default.
• W2101070690 cites W348761501 @default.
• W2101070690 cites W4210956735 @default.
• W2101070690 doi "https://doi.org/10.1155/2013/617809" @default.
• W2101070690 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3876683" @default.
• W2101070690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24416060" @default.
• W2101070690 hasPublicationYear "2013" @default.
• W2101070690 type Work @default.
• W2101070690 sameAs 2101070690 @default.
• W2101070690 citedByCount "29" @default.
• W2101070690 countsByYear W21010706902014 @default.
• W2101070690 countsByYear W21010706902015 @default.
• W2101070690 countsByYear W21010706902016 @default.
• W2101070690 countsByYear W21010706902017 @default.
• W2101070690 countsByYear W21010706902018 @default.
• W2101070690 countsByYear W21010706902019 @default.
• W2101070690 countsByYear W21010706902020 @default.
• W2101070690 countsByYear W21010706902021 @default.
• W2101070690 countsByYear W21010706902022 @default.
• W2101070690 countsByYear W21010706902023 @default.
• W2101070690 crossrefType "journal-article" @default.
• W2101070690 hasAuthorship W2101070690A5019049830 @default.
• W2101070690 hasAuthorship W2101070690A5031165760 @default.
• W2101070690 hasAuthorship W2101070690A5033614715 @default.
• W2101070690 hasAuthorship W2101070690A5043136018 @default.
• W2101070690 hasAuthorship W2101070690A5074199827 @default.
• W2101070690 hasAuthorship W2101070690A5084031628 @default.
• W2101070690 hasAuthorship W2101070690A5086672334 @default.
• W2101070690 hasBestOaLocation W21010706901 @default.
• W2101070690 hasConcept C123012128 @default.
• W2101070690 hasConcept C13373296 @default.
• W2101070690 hasConcept C134659918 @default.
• W2101070690 hasConcept C1491633281 @default.
• W2101070690 hasConcept C16224149 @default.
• W2101070690 hasConcept C171779818 @default.
• W2101070690 hasConcept C202751555 @default.
• W2101070690 hasConcept C203014093 @default.
• W2101070690 hasConcept C2776342803 @default.
• W2101070690 hasConcept C2776914184 @default.
• W2101070690 hasConcept C2909375385 @default.
• W2101070690 hasConcept C53122370 @default.
• W2101070690 hasConcept C54355233 @default.
• W2101070690 hasConcept C85789140 @default.
• W2101070690 hasConcept C86803240 @default.
• W2101070690 hasConcept C8891405 @default.
• W2101070690 hasConcept C95444343 @default.
• W2101070690 hasConceptScore W2101070690C123012128 @default.
• W2101070690 hasConceptScore W2101070690C13373296 @default.
• W2101070690 hasConceptScore W2101070690C134659918 @default.
• W2101070690 hasConceptScore W2101070690C1491633281 @default.
• W2101070690 hasConceptScore W2101070690C16224149 @default.
• W2101070690 hasConceptScore W2101070690C171779818 @default.
• W2101070690 hasConceptScore W2101070690C202751555 @default.
• W2101070690 hasConceptScore W2101070690C203014093 @default.
• W2101070690 hasConceptScore W2101070690C2776342803 @default.
• W2101070690 hasConceptScore W2101070690C2776914184 @default.
• W2101070690 hasConceptScore W2101070690C2909375385 @default.
• W2101070690 hasConceptScore W2101070690C53122370 @default.
• W2101070690 hasConceptScore W2101070690C54355233 @default.
• W2101070690 hasConceptScore W2101070690C85789140 @default.
• W2101070690 hasConceptScore W2101070690C86803240 @default.
• W2101070690 hasConceptScore W2101070690C8891405 @default.
• W2101070690 hasConceptScore W2101070690C95444343 @default.
• W2101070690 hasFunder F4320337365 @default.
• W2101070690 hasLocation W21010706901 @default.
• W2101070690 hasLocation W21010706902 @default.
• W2101070690 hasLocation W21010706903 @default.
• W2101070690 hasLocation W21010706904 @default.
• W2101070690 hasLocation W21010706905 @default.

• next