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• W2101076215 endingPage "e103736" @default.
• W2101076215 startingPage "e103736" @default.
• W2101076215 abstract "As a glycosphingolipid that can bind to several extracellular matrix proteins, sulfatide has the potential to become an effective targeting agent for tumors overexpressing tenasin-C in their microenvironment. To overcome the dose-limiting toxicity of doxorubicin (DOX), a sulfatide-containing nanoliposome (SCN) encapsulation approach was employed to improve treatment efficacy and reduce side effects of free DOX. This study analysed in vitro characteristics of sulfatide-containing nanoliposomal DOX (SCN-DOX) and assessed its cytotoxicity in vitro, as well as biodistribution, therapeutic efficacy, and systemic toxicity in a human glioblastoma U-118MG xenograft model. SCN-DOX was shown to achieve highest drug to lipid ratio (0.5∶1) and a remarkable in vitro stability. Moreover, DOX encapsulated in SCN was shown to be delivered into the nuclei and displayed prolonged retention over free DOX in U-118MG cells. This simple two-lipid SCN-DOX nanodrug has favourable pharmacokinetic attributes in terms of prolonged circulation time, reduced volume of distribution and enhanced bioavailability in healthy rats. As a result of the improved biodistribution, an enhanced treatment efficacy of SCN-DOX was found in glioma-bearing mice compared to the free drug. Finally, a reduction in the accumulation of DOX in the drug's principal toxicity organs achieved by SCN-DOX led to the diminished systemic toxicity as evident from the plasma biochemical analyses. Thus, SCN has the potential to be an effective and safer nano-carrier for targeted delivery of therapeutic agents to tumors with elevated expression of tenascin-C in their microenvironment." @default.
• W2101076215 created "2016-06-24" @default.
• W2101076215 creator A5003883584 @default.
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• W2101076215 date "2014-07-29" @default.
• W2101076215 modified "2023-10-03" @default.
• W2101076215 title "Improved Efficacy and Reduced Toxicity of Doxorubicin Encapsulated in Sulfatide-Containing Nanoliposome in a Glioma Model" @default.
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• W2101076215 cites W1978029175 @default.
• W2101076215 cites W1978421288 @default.
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• W2101076215 cites W2049472191 @default.
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• W2101076215 cites W2092548211 @default.
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• W2101076215 doi "https://doi.org/10.1371/journal.pone.0103736" @default.
• W2101076215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4114873" @default.
• W2101076215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25072631" @default.
• W2101076215 hasPublicationYear "2014" @default.
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