FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101089712> ?p ?o ?g. }

• W2101089712 endingPage "741" @default.
• W2101089712 startingPage "731" @default.
• W2101089712 abstract "Voriconazole is a new triazole antifungal agent with potent, wide-spectrum activity. Its pharmacokinetics and metabolism have been studied in mouse, rat, rabbit, dog, guinea pig, and humans after single and multiple administration by both oral and intravenous routes. Absorption of voriconazole is essentially complete in all species. The elimination of voriconazole is characterized by non-linear pharmacokinetics in all species. Consequently, pharmacokinetic parameters are dependent upon dose, and a superproportional increase in area under the curve is seen with increasing dose in rat and dog toxicology studies. Following multiple administration, there is a decrease in systemic exposure. This is most pronounced in mouse and rat, less so in dog, and not observed in guinea pig or rabbit. Repeat-dose toxicology studies in mouse, rat, and dog have demonstrated that induction of cytochrome P450 by voriconazole (autoinduction of metabolism) is responsible for the decreased exposure in these species. Autoinduction of metabolism is not observed in humans, and plasma steady-state concentrations remain constant with time. Voriconazole is extensively metabolized in all species. The major pathways in humans involve fluoropyrimidine N-oxidation, fluoropyrimidine hydroxylation, and methyl hydroxylation. Also, N-oxidation facilitates cleavage of the molecule, resulting in loss of the fluoropyrimidine moiety and subsequent conjugation with glucuronic acid. Major pathways are represented in animal species. The major circulating metabolite in rat, dog, and human is the N-oxide of voriconazole. It is not thought to contribute to efficacy since it is at least 100-fold less potent than voriconazole against fungal pathogens in vitro." @default.
• W2101089712 created "2016-06-24" @default.
• W2101089712 creator A5002542670 @default.
• W2101089712 creator A5017445984 @default.
• W2101089712 creator A5028451324 @default.
• W2101089712 creator A5033271632 @default.
• W2101089712 creator A5034149008 @default.
• W2101089712 creator A5080811153 @default.
• W2101089712 creator A5082207028 @default.
• W2101089712 creator A5085738200 @default.
• W2101089712 creator A5056074180 @default.
• W2101089712 date "2003-06-01" @default.
• W2101089712 modified "2023-10-13" @default.
• W2101089712 title "THE DISPOSITION OF VORICONAZOLE IN MOUSE, RAT, RABBIT, GUINEA PIG, DOG, AND HUMAN" @default.
• W2101089712 cites W1951469402 @default.
• W2101089712 cites W1967601691 @default.
• W2101089712 cites W1972097392 @default.
• W2101089712 cites W2080721443 @default.
• W2101089712 cites W2086955747 @default.
• W2101089712 cites W2090977130 @default.
• W2101089712 cites W2104241036 @default.
• W2101089712 cites W2119064707 @default.
• W2101089712 cites W2122553675 @default.
• W2101089712 cites W2125636331 @default.
• W2101089712 cites W2126617328 @default.
• W2101089712 cites W2142632979 @default.
• W2101089712 cites W2155556225 @default.
• W2101089712 cites W2473438596 @default.
• W2101089712 cites W2892991835 @default.
• W2101089712 cites W3189204461 @default.
• W2101089712 doi "https://doi.org/10.1124/dmd.31.6.731" @default.
• W2101089712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12756205" @default.
• W2101089712 hasPublicationYear "2003" @default.
• W2101089712 type Work @default.
• W2101089712 sameAs 2101089712 @default.
• W2101089712 citedByCount "285" @default.
• W2101089712 countsByYear W21010897122012 @default.
• W2101089712 countsByYear W21010897122013 @default.
• W2101089712 countsByYear W21010897122014 @default.
• W2101089712 countsByYear W21010897122015 @default.
• W2101089712 countsByYear W21010897122016 @default.
• W2101089712 countsByYear W21010897122017 @default.
• W2101089712 countsByYear W21010897122018 @default.
• W2101089712 countsByYear W21010897122019 @default.
• W2101089712 countsByYear W21010897122020 @default.
• W2101089712 countsByYear W21010897122021 @default.
• W2101089712 countsByYear W21010897122022 @default.
• W2101089712 countsByYear W21010897122023 @default.
• W2101089712 crossrefType "journal-article" @default.
• W2101089712 hasAuthorship W2101089712A5002542670 @default.
• W2101089712 hasAuthorship W2101089712A5017445984 @default.
• W2101089712 hasAuthorship W2101089712A5028451324 @default.
• W2101089712 hasAuthorship W2101089712A5033271632 @default.
• W2101089712 hasAuthorship W2101089712A5034149008 @default.
• W2101089712 hasAuthorship W2101089712A5056074180 @default.
• W2101089712 hasAuthorship W2101089712A5080811153 @default.
• W2101089712 hasAuthorship W2101089712A5082207028 @default.
• W2101089712 hasAuthorship W2101089712A5085738200 @default.
• W2101089712 hasConcept C112705442 @default.
• W2101089712 hasConcept C134018914 @default.
• W2101089712 hasConcept C181199279 @default.
• W2101089712 hasConcept C185592680 @default.
• W2101089712 hasConcept C202751555 @default.
• W2101089712 hasConcept C2777477808 @default.
• W2101089712 hasConcept C2778815084 @default.
• W2101089712 hasConcept C2779548794 @default.
• W2101089712 hasConcept C2780690907 @default.
• W2101089712 hasConcept C2781109383 @default.
• W2101089712 hasConcept C526171541 @default.
• W2101089712 hasConcept C55493867 @default.
• W2101089712 hasConcept C62231903 @default.
• W2101089712 hasConcept C86803240 @default.
• W2101089712 hasConcept C89423630 @default.
• W2101089712 hasConcept C98274493 @default.
• W2101089712 hasConceptScore W2101089712C112705442 @default.
• W2101089712 hasConceptScore W2101089712C134018914 @default.
• W2101089712 hasConceptScore W2101089712C181199279 @default.
• W2101089712 hasConceptScore W2101089712C185592680 @default.
• W2101089712 hasConceptScore W2101089712C202751555 @default.
• W2101089712 hasConceptScore W2101089712C2777477808 @default.
• W2101089712 hasConceptScore W2101089712C2778815084 @default.
• W2101089712 hasConceptScore W2101089712C2779548794 @default.
• W2101089712 hasConceptScore W2101089712C2780690907 @default.
• W2101089712 hasConceptScore W2101089712C2781109383 @default.
• W2101089712 hasConceptScore W2101089712C526171541 @default.
• W2101089712 hasConceptScore W2101089712C55493867 @default.
• W2101089712 hasConceptScore W2101089712C62231903 @default.
• W2101089712 hasConceptScore W2101089712C86803240 @default.
• W2101089712 hasConceptScore W2101089712C89423630 @default.
• W2101089712 hasConceptScore W2101089712C98274493 @default.
• W2101089712 hasIssue "6" @default.
• W2101089712 hasLocation W21010897121 @default.
• W2101089712 hasLocation W21010897122 @default.
• W2101089712 hasOpenAccess W2101089712 @default.
• W2101089712 hasPrimaryLocation W21010897121 @default.
• W2101089712 hasRelatedWork W1492229869 @default.
• W2101089712 hasRelatedWork W2055277487 @default.
• W2101089712 hasRelatedWork W2056938528 @default.

• next