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• W2101095087 endingPage "1992" @default.
• W2101095087 startingPage "1983" @default.
• W2101095087 abstract "The mitotic state is associated with a generalized repression of transcription. We show that mitotic repression of RNA polymerase III transcription can be reproduced by using extracts of synchronized HeLa cells. We have used this system to investigate the molecular basis of transcriptional repression during mitosis. We find a specific decrease in the activity of the TATA-binding-protein (TBP)-containing complex TFIIIB. TBP itself is hyperphosphorylated at mitosis, but this does not appear to account for the loss of TFIIIB activity. Instead, one or more TBP-associated components appear to be regulated. The data suggest that changes in the activity of TBP-associated components contribute to the coordinate repression of gene expression that occurs at mitosis." @default.
• W2101095087 created "2016-06-24" @default.
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• W2101095087 date "1995-04-01" @default.
• W2101095087 modified "2023-10-15" @default.
• W2101095087 title "Mitotic Regulation of a TATA-Binding-Protein-Containing Complex" @default.
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• W2101095087 doi "https://doi.org/10.1128/mcb.15.4.1983" @default.
• W2101095087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/230425" @default.
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