FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101095327> ?p ?o ?g. }

• W2101095327 endingPage "12" @default.
• W2101095327 startingPage "6" @default.
• W2101095327 abstract "Aims: The incidence of head and neck cancer (HNC) in Brazil has increased substantially in recent years. This increase is likely to be strongly associated with alcohol and tobacco consumption, but genetic susceptibility also should be investigated in this population. The aim of this study was to evaluate the association of polymorphisms in genes of alcohol metabolism enzymes and the risk of HNC. Methods: A hospital-based case–control study was conducted in São Paulo, Brazil. We here investigated ADH1C Ile350Val, ADH1B Arg48His, ADH1B Arg370Cys and CYP2E1*5A PstI polymorphisms by PCR-RFLP Polymerase Chain Reaction - Restriction Fragment Length Polymorphism in 207 histopathologically confirmed HNC cases (184 males and 23 females) and 244 cancer-free controls (225 males and 19 females) admitted as in-patients in the same hospital. Results: Chronic alcohol intake increased approximately four times the risk of HNC. The mutant genotype ADH1B Arg48His was more frequent in controls (12.7%) than HNC patients (5.8%) conferring protection for the disease (odds ratio (OR) = 0.42; 95% confidence interval (CI ), 0.21–0.85). Similar results were observed for individuals with ADH1B*2 (OR = 0.41; 95% CI , 0.20–0.82) or ADH1B*2/ADH1C*1 (OR = 0.32; 95% CI , 0.13–0.79) mutated haplotypes. Multiple regression analyses showed that individuals with the mutant genotype ADH1B Arg48His who consume alcohol >30 g/L/day have more than four times the risk for HNC (OR = 4.42; 95% CI, 1.21–16.11). Conclusions: The fast alcohol metabolizing genotypes may prevent HNC when the amount of alcohol intake is <30.655 g/L/day." @default.
• W2101095327 created "2016-06-24" @default.
• W2101095327 creator A5003490938 @default.
• W2101095327 creator A5059496631 @default.
• W2101095327 creator A5061106710 @default.
• W2101095327 creator A5078826581 @default.
• W2101095327 date "2009-11-03" @default.
• W2101095327 modified "2023-10-17" @default.
• W2101095327 title "Polymorphisms in Alcohol Metabolizing Genes and the Risk of Head and Neck Cancer in a Brazilian Population" @default.
• W2101095327 cites W1989754098 @default.
• W2101095327 cites W1999401667 @default.
• W2101095327 cites W2004947323 @default.
• W2101095327 cites W2015452353 @default.
• W2101095327 cites W2020738930 @default.
• W2101095327 cites W2028341864 @default.
• W2101095327 cites W2031448733 @default.
• W2101095327 cites W2047238729 @default.
• W2101095327 cites W2074695184 @default.
• W2101095327 cites W2075071788 @default.
• W2101095327 cites W2094286829 @default.
• W2101095327 cites W2100811636 @default.
• W2101095327 cites W2101181611 @default.
• W2101095327 cites W2108836663 @default.
• W2101095327 cites W2116335549 @default.
• W2101095327 cites W2117395370 @default.
• W2101095327 cites W2118094114 @default.
• W2101095327 cites W2125414552 @default.
• W2101095327 cites W2129159553 @default.
• W2101095327 cites W2138653788 @default.
• W2101095327 cites W2139432096 @default.
• W2101095327 cites W2154272355 @default.
• W2101095327 cites W2159487367 @default.
• W2101095327 cites W2166050484 @default.
• W2101095327 cites W2169868655 @default.
• W2101095327 cites W4237120149 @default.
• W2101095327 cites W4241577617 @default.
• W2101095327 doi "https://doi.org/10.1093/alcalc/agp078" @default.
• W2101095327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19887496" @default.
• W2101095327 hasPublicationYear "2009" @default.
• W2101095327 type Work @default.
• W2101095327 sameAs 2101095327 @default.
• W2101095327 citedByCount "14" @default.
• W2101095327 countsByYear W21010953272012 @default.
• W2101095327 countsByYear W21010953272013 @default.
• W2101095327 countsByYear W21010953272015 @default.
• W2101095327 countsByYear W21010953272016 @default.
• W2101095327 countsByYear W21010953272017 @default.
• W2101095327 countsByYear W21010953272019 @default.
• W2101095327 crossrefType "journal-article" @default.
• W2101095327 hasAuthorship W2101095327A5003490938 @default.
• W2101095327 hasAuthorship W2101095327A5059496631 @default.
• W2101095327 hasAuthorship W2101095327A5061106710 @default.
• W2101095327 hasAuthorship W2101095327A5078826581 @default.
• W2101095327 hasBestOaLocation W21010953271 @default.
• W2101095327 hasConcept C104317684 @default.
• W2101095327 hasConcept C121608353 @default.
• W2101095327 hasConcept C126322002 @default.
• W2101095327 hasConcept C135763542 @default.
• W2101095327 hasConcept C146304588 @default.
• W2101095327 hasConcept C151325109 @default.
• W2101095327 hasConcept C156957248 @default.
• W2101095327 hasConcept C181199279 @default.
• W2101095327 hasConcept C197754878 @default.
• W2101095327 hasConcept C2776317432 @default.
• W2101095327 hasConcept C2776530083 @default.
• W2101095327 hasConcept C2908647359 @default.
• W2101095327 hasConcept C44249647 @default.
• W2101095327 hasConcept C54355233 @default.
• W2101095327 hasConcept C55493867 @default.
• W2101095327 hasConcept C71924100 @default.
• W2101095327 hasConcept C86803240 @default.
• W2101095327 hasConcept C90924648 @default.
• W2101095327 hasConcept C96722902 @default.
• W2101095327 hasConcept C99454951 @default.
• W2101095327 hasConceptScore W2101095327C104317684 @default.
• W2101095327 hasConceptScore W2101095327C121608353 @default.
• W2101095327 hasConceptScore W2101095327C126322002 @default.
• W2101095327 hasConceptScore W2101095327C135763542 @default.
• W2101095327 hasConceptScore W2101095327C146304588 @default.
• W2101095327 hasConceptScore W2101095327C151325109 @default.
• W2101095327 hasConceptScore W2101095327C156957248 @default.
• W2101095327 hasConceptScore W2101095327C181199279 @default.
• W2101095327 hasConceptScore W2101095327C197754878 @default.
• W2101095327 hasConceptScore W2101095327C2776317432 @default.
• W2101095327 hasConceptScore W2101095327C2776530083 @default.
• W2101095327 hasConceptScore W2101095327C2908647359 @default.
• W2101095327 hasConceptScore W2101095327C44249647 @default.
• W2101095327 hasConceptScore W2101095327C54355233 @default.
• W2101095327 hasConceptScore W2101095327C55493867 @default.
• W2101095327 hasConceptScore W2101095327C71924100 @default.
• W2101095327 hasConceptScore W2101095327C86803240 @default.
• W2101095327 hasConceptScore W2101095327C90924648 @default.
• W2101095327 hasConceptScore W2101095327C96722902 @default.
• W2101095327 hasConceptScore W2101095327C99454951 @default.
• W2101095327 hasIssue "1" @default.
• W2101095327 hasLocation W21010953271 @default.
• W2101095327 hasLocation W21010953272 @default.
• W2101095327 hasOpenAccess W2101095327 @default.

• next