Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101096919> ?p ?o ?g. }
- W2101096919 endingPage "128" @default.
- W2101096919 startingPage "121" @default.
- W2101096919 abstract "Morbidity and mortality after admission for acute heart failure remain prohibitively high. In that setting, plasma levels of antigen carbohydrate 125 have shown to correlate with the severity of fluid overload and the risk of mortality and readmission. Preliminary data suggests a potential role of antigen carbohydrate 125 to guide therapy. The objective of this study is to evaluate the prognostic effect of an antigen carbohydrate 125-guided management strategy vs standard therapy in patients recently discharged for acute heart failure.This is a multicenter, randomized, single-blind, efficacy trial study of patients recently discharged from acute heart failure (< 180 days), New York Heart Association functional class II-IV and antigen carbohydrate 125 > 35 U/ml. A randomization scheme was used to allocate participants (in a 1:1 ratio) to receive therapy guided by antigen carbohydrate 125 (aiming to keep normal values) or standard treatment. Mainly, antigen carbohydrate 125-guided therapy is focused on the frequency of monitoring and titration of decongestive therapies and statins. As of December 10, 2013, there were 383 patients enrolled. The primary outcome was the composite of 1-year all-cause mortality or rehospitalization for acute heart failure. Analysis was planned to be intention-to-treat.Discovering novel therapeutic strategies or finding better ways of optimizing established treatments have become a health care priority in heart failure. This study will add important knowledge about the potential of antigen carbohydrate 125 as a management tool for monitoring and titration of therapies where optimal utilization has not been well defined, such as diuretics and statins.ClinicalTrials.gov number: NCT02008110." @default.
- W2101096919 created "2016-06-24" @default.
- W2101096919 creator A5000375555 @default.
- W2101096919 creator A5003576155 @default.
- W2101096919 creator A5004444515 @default.
- W2101096919 creator A5006357262 @default.
- W2101096919 creator A5012410836 @default.
- W2101096919 creator A5019360089 @default.
- W2101096919 creator A5024599463 @default.
- W2101096919 creator A5047182336 @default.
- W2101096919 creator A5059790781 @default.
- W2101096919 creator A5070470399 @default.
- W2101096919 creator A5077408960 @default.
- W2101096919 creator A5078234495 @default.
- W2101096919 creator A5088268019 @default.
- W2101096919 creator A5090236993 @default.
- W2101096919 date "2015-02-01" @default.
- W2101096919 modified "2023-10-18" @default.
- W2101096919 title "Prognostic Effect of Carbohydrate Antigen 125-guided Therapy in Patients Recently Discharged for Acute Heart Failure (CHANCE-HF). Study Design" @default.
- W2101096919 cites W182356710 @default.
- W2101096919 cites W1973770406 @default.
- W2101096919 cites W1997638871 @default.
- W2101096919 cites W2005068749 @default.
- W2101096919 cites W2017088015 @default.
- W2101096919 cites W2018065665 @default.
- W2101096919 cites W2023118519 @default.
- W2101096919 cites W2030945290 @default.
- W2101096919 cites W2051881604 @default.
- W2101096919 cites W2052953200 @default.
- W2101096919 cites W2057061319 @default.
- W2101096919 cites W2062594859 @default.
- W2101096919 cites W2062633545 @default.
- W2101096919 cites W2071621271 @default.
- W2101096919 cites W2095056452 @default.
- W2101096919 cites W2099012986 @default.
- W2101096919 cites W2099528624 @default.
- W2101096919 cites W2102754127 @default.
- W2101096919 cites W2105095326 @default.
- W2101096919 cites W2110385447 @default.
- W2101096919 cites W2113188353 @default.
- W2101096919 cites W2118196805 @default.
- W2101096919 cites W2119254117 @default.
- W2101096919 cites W2119340816 @default.
- W2101096919 cites W2122074886 @default.
- W2101096919 cites W2126452437 @default.
- W2101096919 cites W2134526322 @default.
- W2101096919 cites W2146560507 @default.
- W2101096919 cites W2152264817 @default.
- W2101096919 cites W2153475493 @default.
- W2101096919 cites W2160117042 @default.
- W2101096919 cites W2167075471 @default.
- W2101096919 cites W2740626011 @default.
- W2101096919 cites W4293872547 @default.
- W2101096919 cites W82015992 @default.
- W2101096919 doi "https://doi.org/10.1016/j.rec.2014.03.018" @default.
- W2101096919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25623430" @default.
- W2101096919 hasPublicationYear "2015" @default.
- W2101096919 type Work @default.
- W2101096919 sameAs 2101096919 @default.
- W2101096919 citedByCount "1" @default.
- W2101096919 countsByYear W21010969192018 @default.
- W2101096919 crossrefType "journal-article" @default.
- W2101096919 hasAuthorship W2101096919A5000375555 @default.
- W2101096919 hasAuthorship W2101096919A5003576155 @default.
- W2101096919 hasAuthorship W2101096919A5004444515 @default.
- W2101096919 hasAuthorship W2101096919A5006357262 @default.
- W2101096919 hasAuthorship W2101096919A5012410836 @default.
- W2101096919 hasAuthorship W2101096919A5019360089 @default.
- W2101096919 hasAuthorship W2101096919A5024599463 @default.
- W2101096919 hasAuthorship W2101096919A5047182336 @default.
- W2101096919 hasAuthorship W2101096919A5059790781 @default.
- W2101096919 hasAuthorship W2101096919A5070470399 @default.
- W2101096919 hasAuthorship W2101096919A5077408960 @default.
- W2101096919 hasAuthorship W2101096919A5078234495 @default.
- W2101096919 hasAuthorship W2101096919A5088268019 @default.
- W2101096919 hasAuthorship W2101096919A5090236993 @default.
- W2101096919 hasConcept C126322002 @default.
- W2101096919 hasConcept C147483822 @default.
- W2101096919 hasConcept C164705383 @default.
- W2101096919 hasConcept C168563851 @default.
- W2101096919 hasConcept C177713679 @default.
- W2101096919 hasConcept C203014093 @default.
- W2101096919 hasConcept C204243189 @default.
- W2101096919 hasConcept C2778198053 @default.
- W2101096919 hasConcept C71924100 @default.
- W2101096919 hasConceptScore W2101096919C126322002 @default.
- W2101096919 hasConceptScore W2101096919C147483822 @default.
- W2101096919 hasConceptScore W2101096919C164705383 @default.
- W2101096919 hasConceptScore W2101096919C168563851 @default.
- W2101096919 hasConceptScore W2101096919C177713679 @default.
- W2101096919 hasConceptScore W2101096919C203014093 @default.
- W2101096919 hasConceptScore W2101096919C204243189 @default.
- W2101096919 hasConceptScore W2101096919C2778198053 @default.
- W2101096919 hasConceptScore W2101096919C71924100 @default.
- W2101096919 hasIssue "2" @default.
- W2101096919 hasLocation W21010969191 @default.
- W2101096919 hasLocation W21010969192 @default.
- W2101096919 hasOpenAccess W2101096919 @default.