Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101103196> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2101103196 endingPage "51" @default.
- W2101103196 startingPage "51" @default.
- W2101103196 abstract "CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle Annateresa Papazzo1, Louise Lexis2, Paul Lewandowski11Molecular Nutrition Unit, School of Medicine, Deakin University, Victoria, Australia; 2School of Human Biosciences, La Trobe University, Victoria, AustraliaAbstract: Coenzyme Q10 (CoQ10) is commonly consumed as an antiaging supplement at doses of 30–210 mg/day. The aim of the study was to determine if CoQ10 alters markers of antioxidant status, oxidative damage, and gene expression in aging skeletal muscle. Female guinea pigs aged 26 months were supplemented for 6 weeks with CoQ10 at a human equivalent dose of 10 mg/kg/day. Body weight, plasma CoQ10 concentration, and WBC DNA abasic sites were measured at weeks 0, 2, 4, and 6 of the supplementation period. At the end of supplementation, concentrations of skeletal muscle CoQ10, glutathione, malondialdehyde, protein carbonyls, DNA abasic sites, activities of catalase and glutathione peroxidase, and the gene expression of cyctochrome c oxidase subunits were measured. Dietary supplementation with CoQ10 elevated plasma CoQ10 levels (pre 73 ± 3 nmol/L, post 581 ± 15 nmol/L, P < 0.05) and decreased abasic sites in WBC DNA (pre 16.8 ± 0.5 Ap/100000 bp, post 9.7 ± 0.4 Ap/100000 bp, P < 0.05). In contrast, all of the measures made in skeletal muscle were not different between groups (P > 0.05). These results indicate that dietary supplementation with CoQ10 at a dose of 10 mg/kg/day may be capable of increasing antioxidant protection and reducing oxidative damage in the plasma, but may have no effect in skeletal muscle.Keywords: coenzyme Q10, aging, skeletal muscle, oxidative damage, gene expression" @default.
- W2101103196 created "2016-06-24" @default.
- W2101103196 creator A5020696374 @default.
- W2101103196 creator A5041904244 @default.
- W2101103196 creator A5051006782 @default.
- W2101103196 date "2010-07-01" @default.
- W2101103196 modified "2023-09-27" @default.
- W2101103196 title "CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle" @default.
- W2101103196 cites W1601027696 @default.
- W2101103196 cites W1768247331 @default.
- W2101103196 cites W1903290798 @default.
- W2101103196 cites W1947329737 @default.
- W2101103196 cites W1972782064 @default.
- W2101103196 cites W1974315138 @default.
- W2101103196 cites W1983421623 @default.
- W2101103196 cites W1993699862 @default.
- W2101103196 cites W2002973721 @default.
- W2101103196 cites W2003604507 @default.
- W2101103196 cites W2004675210 @default.
- W2101103196 cites W2011643270 @default.
- W2101103196 cites W2049804061 @default.
- W2101103196 cites W2057177336 @default.
- W2101103196 cites W2080754372 @default.
- W2101103196 cites W2085396235 @default.
- W2101103196 cites W2099354599 @default.
- W2101103196 cites W2102623742 @default.
- W2101103196 cites W2106936194 @default.
- W2101103196 cites W2114244415 @default.
- W2101103196 cites W2115040746 @default.
- W2101103196 cites W2121599941 @default.
- W2101103196 cites W2121836743 @default.
- W2101103196 cites W2128865254 @default.
- W2101103196 cites W2138961575 @default.
- W2101103196 cites W2161701567 @default.
- W2101103196 cites W2171088963 @default.
- W2101103196 doi "https://doi.org/10.2147/nds.s10955" @default.
- W2101103196 hasPublicationYear "2010" @default.
- W2101103196 type Work @default.
- W2101103196 sameAs 2101103196 @default.
- W2101103196 citedByCount "0" @default.
- W2101103196 crossrefType "journal-article" @default.
- W2101103196 hasAuthorship W2101103196A5020696374 @default.
- W2101103196 hasAuthorship W2101103196A5041904244 @default.
- W2101103196 hasAuthorship W2101103196A5051006782 @default.
- W2101103196 hasBestOaLocation W21011031961 @default.
- W2101103196 hasConcept C126322002 @default.
- W2101103196 hasConcept C134018914 @default.
- W2101103196 hasConcept C181199279 @default.
- W2101103196 hasConcept C185592680 @default.
- W2101103196 hasConcept C2776151105 @default.
- W2101103196 hasConcept C2778004101 @default.
- W2101103196 hasConcept C2778401633 @default.
- W2101103196 hasConcept C2778760513 @default.
- W2101103196 hasConcept C2778979269 @default.
- W2101103196 hasConcept C2779384338 @default.
- W2101103196 hasConcept C2779959927 @default.
- W2101103196 hasConcept C538909803 @default.
- W2101103196 hasConcept C55493867 @default.
- W2101103196 hasConcept C71924100 @default.
- W2101103196 hasConcept C86803240 @default.
- W2101103196 hasConceptScore W2101103196C126322002 @default.
- W2101103196 hasConceptScore W2101103196C134018914 @default.
- W2101103196 hasConceptScore W2101103196C181199279 @default.
- W2101103196 hasConceptScore W2101103196C185592680 @default.
- W2101103196 hasConceptScore W2101103196C2776151105 @default.
- W2101103196 hasConceptScore W2101103196C2778004101 @default.
- W2101103196 hasConceptScore W2101103196C2778401633 @default.
- W2101103196 hasConceptScore W2101103196C2778760513 @default.
- W2101103196 hasConceptScore W2101103196C2778979269 @default.
- W2101103196 hasConceptScore W2101103196C2779384338 @default.
- W2101103196 hasConceptScore W2101103196C2779959927 @default.
- W2101103196 hasConceptScore W2101103196C538909803 @default.
- W2101103196 hasConceptScore W2101103196C55493867 @default.
- W2101103196 hasConceptScore W2101103196C71924100 @default.
- W2101103196 hasConceptScore W2101103196C86803240 @default.
- W2101103196 hasLocation W21011031961 @default.
- W2101103196 hasLocation W21011031962 @default.
- W2101103196 hasOpenAccess W2101103196 @default.
- W2101103196 hasPrimaryLocation W21011031961 @default.
- W2101103196 hasRelatedWork W1869058931 @default.
- W2101103196 hasRelatedWork W1967047574 @default.
- W2101103196 hasRelatedWork W1969555927 @default.
- W2101103196 hasRelatedWork W1993548188 @default.
- W2101103196 hasRelatedWork W2067568257 @default.
- W2101103196 hasRelatedWork W2462774294 @default.
- W2101103196 hasRelatedWork W2793794267 @default.
- W2101103196 hasRelatedWork W3200659209 @default.
- W2101103196 hasRelatedWork W3214998341 @default.
- W2101103196 hasRelatedWork W4315491170 @default.
- W2101103196 isParatext "false" @default.
- W2101103196 isRetracted "false" @default.
- W2101103196 magId "2101103196" @default.
- W2101103196 workType "article" @default.