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• W210113638 abstract "Ischemic heart disease remains the leading cause of death worldwide. Ischemic pre-, post-, and remote conditionings trigger endogenous cardioprotection that renders the heart resistant to ischemic-reperfusion injury (IRI). Mimicking endogenous cardioprotection by modulating genes involved in cardioprotective signal transduction provides an opportunity to reproduce endogenous cardioprotection with better possibilities of translation into the clinical setting. Genes and signaling pathways by which conditioning maneuvers exert their effects on the heart are partially understood. This is due to the targeted approach that allowed identifying one or a few genes associated with IRI and cardioprotection. Genes critical for signaling pathways in cardioprotection include protectomiRs (e.g., microRNA 125b*), ZAC1 transcription factor, pro-inflammatory genes such as cycloxygenase (COX)-2 and inducible nitric oxide synthase (iNOS), antioxidant enzymes such as hemoxygenase (HO)-1, extracellular and manganese superoxidase dismutases (ec-SOD and Mg-SOD), heat shock proteins (HSPs), growth factors such as insulin like growth factor (IGF)-1 and hepatocyte growth factor (HGF), antiapoptotic proteins such as Bcl-2 and Bcl-xL, pro-apoptotic proteins such as FasL, Bcl-2, Bax, caspase-3 and p53, and proangiogenic genes such as TGFbeta, sphingosine kinase 1 (SPK1), and PI3K-Akt. By identifying the gene expression profiles of IRI and ischemic conditioning, one may reveal potential gene targets responsible for cardioprotection. In this manuscript, we review the current state of the art of gene therapy in cardioprotection and propose that gene expression analysis facilitates the identification of individual genes associated with cardioprotection. We discuss signaling pathways associated with cardioprotection that can be targeted by gene therapy to achieve cardioprotection." @default.
• W210113638 created "2016-06-24" @default.
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• W210113638 date "2015-07-01" @default.
• W210113638 modified "2023-10-17" @default.
• W210113638 title "Cardioprotection by gene therapy" @default.
• W210113638 cites W1506297407 @default.
• W210113638 cites W1964972368 @default.
• W210113638 cites W1969387172 @default.
• W210113638 cites W1970824460 @default.
• W210113638 cites W1971776562 @default.
• W210113638 cites W1978221784 @default.
• W210113638 cites W1980994248 @default.
• W210113638 cites W1985465262 @default.
• W210113638 cites W1988971910 @default.
• W210113638 cites W1991287561 @default.
• W210113638 cites W1992506240 @default.
• W210113638 cites W2002411539 @default.
• W210113638 cites W2008318207 @default.
• W210113638 cites W2009777524 @default.
• W210113638 cites W2010424165 @default.
• W210113638 cites W2011785467 @default.
• W210113638 cites W2011830144 @default.
• W210113638 cites W2014044948 @default.
• W210113638 cites W2017610560 @default.
• W210113638 cites W2021142885 @default.
• W210113638 cites W2024201524 @default.
• W210113638 cites W2025311714 @default.
• W210113638 cites W2026730028 @default.
• W210113638 cites W2035525989 @default.
• W210113638 cites W2043081679 @default.
• W210113638 cites W2048543877 @default.
• W210113638 cites W2049442397 @default.
• W210113638 cites W2055424060 @default.
• W210113638 cites W2058795101 @default.
• W210113638 cites W2059118467 @default.
• W210113638 cites W2059578202 @default.
• W210113638 cites W2061495392 @default.
• W210113638 cites W2063217628 @default.
• W210113638 cites W2065784785 @default.
• W210113638 cites W2067943009 @default.
• W210113638 cites W2069360041 @default.
• W210113638 cites W2070496950 @default.
• W210113638 cites W2073909046 @default.
• W210113638 cites W2077031977 @default.
• W210113638 cites W2087246710 @default.
• W210113638 cites W2092272253 @default.
• W210113638 cites W2094866111 @default.
• W210113638 cites W2096213334 @default.
• W210113638 cites W2096541614 @default.
• W210113638 cites W2103002981 @default.
• W210113638 cites W2106922430 @default.
• W210113638 cites W2107732417 @default.
• W210113638 cites W2108696133 @default.
• W210113638 cites W2110204147 @default.
• W210113638 cites W2111954747 @default.
• W210113638 cites W2119927647 @default.
• W210113638 cites W2120559017 @default.
• W210113638 cites W2128960919 @default.
• W210113638 cites W2130568284 @default.
• W210113638 cites W2132494613 @default.
• W210113638 cites W2133193767 @default.
• W210113638 cites W2136273830 @default.
• W210113638 cites W2136390065 @default.
• W210113638 cites W2141123335 @default.
• W210113638 cites W2143657744 @default.
• W210113638 cites W2146555951 @default.
• W210113638 cites W2146617313 @default.
• W210113638 cites W2147135453 @default.
• W210113638 cites W2148778286 @default.
• W210113638 cites W2150778794 @default.
• W210113638 cites W2151884159 @default.
• W210113638 cites W2156680488 @default.
• W210113638 cites W2160696128 @default.
• W210113638 cites W2161319100 @default.
• W210113638 cites W2163480486 @default.
• W210113638 cites W2169151112 @default.
• W210113638 cites W2171584616 @default.
• W210113638 cites W2179994459 @default.
• W210113638 doi "https://doi.org/10.1016/j.ijcard.2015.04.232" @default.
• W210113638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25974196" @default.
• W210113638 hasPublicationYear "2015" @default.

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