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• W2101176509 abstract "Background: We assessed the possibility of using myo-inositol as a marker of glucose intolerance. Methods: We measured urinary myo-inositol enzymatically before and 2 h after a 75-g oral glucose tolerance test in 564 volunteers, who were divided into four groups [normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus (DM)]. Furthermore, we classified NGT into NGT-A (2-h blood glucose <120 mg/dl and 2-h glucosuria <50 mg/dl) and NGT-B (remaining NGT subjects). We then compared Δmyo-inositol (myo-inositol/creatinine ratio: 2-h after glucose load—before load) of each group to investigate the relationship between glucose intolerance and Δmyo-inositol. Results: The glucose tolerance of NGT-B appeared to have deteriorated compared with NGT-A as determined by blood glucose, insulin, and glucosuria. There was very little effect of gender or age on Δmyo-inositol in NGT-A. Δmyo-inositol was significantly higher than that in NGT-A (0.5±7.1 mg/g Cr) not only in IFG (8.7±19.5 mg/g Cr, P<0.0001), IGT (14.8±22.9 mg/g Cr, P<0.0001) and DM (79.5±37.1 mg/g Cr, P<0.0001), but in NGT-B (7.4±12.7 mg/g Cr, P<0.0001). With 2 mg/g Cr as a tentative cut-off for Δmyo-inositol to detect NGT-A, sensitivity and specificity were 68% and 72%, respectively. Conclusions: The Δmyo-inositol can be use of a non-invasive and sensitive marker for glucose intolerance." @default.
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• W2101176509 date "2004-06-01" @default.
• W2101176509 modified "2023-10-18" @default.
• W2101176509 title "A study of urinary myo-inositol as a sensitive marker of glucose intolerance" @default.
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• W2101176509 doi "https://doi.org/10.1016/j.cccn.2004.02.026" @default.
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