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• W2101183670 abstract "Epithelial–mesenchymal transition (EMT) is thought to be an important, possibly essential, component of the process of tumor dissemination and metastasis. About 20%–30% of Hras mutant mouse skin carcinomas induced by chemical initiation/promotion protocols have undergone EMT. Reduced exposure to TPA-induced chronic inflammation causes a dramatic reduction in classical papillomas and squamous cell carcinomas (SCCs), but the mice still develop highly invasive carcinomas with EMT properties, reduced levels of Hras and Egfr signaling, and frequent Ink4/Arf deletions. Deletion of Hras from the mouse germline also leads to a strong reduction in squamous tumor development, but tumors now acquire activating Kras mutations and exhibit more aggressive metastatic properties. We propose that invasive carcinomas can arise by different genetic and biological routes dependent on exposure to chronic inflammation and possibly from different target cell populations within the skin. Our data have implications for the use of inhibitors of inflammation or of Ras/Egfr pathway signaling for prevention or treatment of invasive cancers." @default.
• W2101183670 created "2016-06-24" @default.
• W2101183670 creator A5033599840 @default.
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• W2101183670 creator A5050117160 @default.
• W2101183670 creator A5087232091 @default.
• W2101183670 date "2013-03-15" @default.
• W2101183670 modified "2023-09-25" @default.
• W2101183670 title "Inflammation and Hras signaling control epithelial–mesenchymal transition during skin tumor progression" @default.
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• W2101183670 doi "https://doi.org/10.1101/gad.210427.112" @default.
• W2101183670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3613613" @default.
• W2101183670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23512660" @default.
• W2101183670 hasPublicationYear "2013" @default.
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