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• W2101199868 abstract "No AccessJournal of UrologyInvestigative Urology1 May 2008Voiding Pattern Analysis as a Surrogate for Cystometric Evaluation in Uroplakin II Knockout Miceis companion ofInfluence of Pelvic Floor Muscle Contraction on the Profile of Vaginal Closure Pressure in Continent and Stress Urinary Incontinent WomenMonocyte Chemoattractant Protein-1 and Macrophage Inflammatory Protein-1α as Possible Biomarkers for the Chronic Pelvic Pain SyndromeUrine Markers Do Not Predict Biopsy Findings or Presence of Bladder Ulcers in Interstitial Cystitis/Painful Bladder Syndrome Steve J. Hodges, Ge Zhou, Fang-Ming Deng, Tamer Aboushwareb, Chanda Turner, Karl-Erik Andersson, Pete Santago, Doug Case, Tung-Tien Sun, and George J. Christ Steve J. HodgesSteve J. Hodges Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina Equal study contribution. More articles by this author , Ge ZhouGe Zhou Departments of Cell Biology, Dermatology, Pharmacology and Urology, New York University School of Medicine, New York, New York Equal study contribution. More articles by this author , Fang-Ming DengFang-Ming Deng Departments of Cell Biology, Dermatology, Pharmacology and Urology, New York University School of Medicine, New York, New York More articles by this author , Tamer AboushwarebTamer Aboushwareb Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author , Chanda TurnerChanda Turner Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author , Karl-Erik AnderssonKarl-Erik Andersson Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author , Pete SantagoPete Santago Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author , Doug CaseDoug Case Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author , Tung-Tien SunTung-Tien Sun Departments of Cell Biology, Dermatology, Pharmacology and Urology, New York University School of Medicine, New York, New York More articles by this author , and George J. ChristGeorge J. Christ Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.12.039AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Previous study has shown that the absence of uroplakin II can cause urinary tract dysfunction, including vesicoureteral reflux and renal abnormalities, as well as micturition pattern changes. We developed a simple surrogate measure of bladder function using ultraviolet visualization of urinary voiding patterns in a uroplakin II knockout mouse animal model. Materials and Methods: Three male and 3 female WT mice, and 3 male and 3 female uroplakin II knockout mice were evaluated by cystometric analysis and voiding pattern markings. Voiding pattern markings were graded by independent observers on a scale of 1 to 5 according to the degree of dispersion of voided urine. Statistical analysis was then used to correlate voiding dispersion grades with cystometric parameters in the same mice. Results: The degree of dispersion of voiding pattern markings correlated with several measures of bladder function. Specifically the Pearson correlation coefficients for the observed voiding patterns highly correlated with baseline pressure, threshold pressure and intermicturition pressure measurements made during conscious cystometry in these mice (p <0.05). Conclusions: Ultraviolet visualization of urinary voiding patterns of mice correlated well with certain measures of standard cystometric evaluations. As such, this method provides a simple, noninvasive method of evaluating mouse bladder function. Implementation of this methodology, which can potentially be automated for high throughput analysis, can accelerate the development of novel therapy for certain important aspects of bladder disease/dysfunction. References 1 : Overcoming Bladder Disease: A Strategic Plan for Research. Bethesda: National Institutes of Health2002. Google Scholar 2 : The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn2002; 21: 167. Google Scholar 3 : Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. Eur Urol2006; 50: 1306. Google Scholar 4 : How widespread are the symptoms of an overactive bladder and how are they managed?: A population-based prevalence study. BJU Int2001; 87: 760. Google Scholar 5 : Prevalence and burden of overactive bladder in the United States. 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Google Scholar © 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byStephany H, Strand D, Ching C, Tanaka S, Milne G, Cajaiba M, Thomas J, Pope J, Adams M, Brock J, Hayward S, Matusik R and Clayton D (2013) Chronic Cyclic Bladder Over Distention Up-Regulates Hypoxia Dependent PathwaysJournal of Urology, VOL. 190, NO. 4S, (1603-1609), Online publication date: 1-Oct-2013.Related articlesJournal of Urology18 Mar 2008Influence of Pelvic Floor Muscle Contraction on the Profile of Vaginal Closure Pressure in Continent and Stress Urinary Incontinent WomenJournal of Urology18 Mar 2008Monocyte Chemoattractant Protein-1 and Macrophage Inflammatory Protein-1α as Possible Biomarkers for the Chronic Pelvic Pain SyndromeJournal of Urology18 Mar 2008Urine Markers Do Not Predict Biopsy Findings or Presence of Bladder Ulcers in Interstitial Cystitis/Painful Bladder Syndrome Volume 179Issue 5May 2008Page: 2046-2051 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordsbladderurinationuroplakin IImiceMetricsAuthor Information Steve J. Hodges Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina Equal study contribution. More articles by this author Ge Zhou Departments of Cell Biology, Dermatology, Pharmacology and Urology, New York University School of Medicine, New York, New York Equal study contribution. More articles by this author Fang-Ming Deng Departments of Cell Biology, Dermatology, Pharmacology and Urology, New York University School of Medicine, New York, New York More articles by this author Tamer Aboushwareb Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author Chanda Turner Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author Karl-Erik Andersson Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author Pete Santago Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author Doug Case Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author Tung-Tien Sun Departments of Cell Biology, Dermatology, Pharmacology and Urology, New York University School of Medicine, New York, New York More articles by this author George J. Christ Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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