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• W2101214162 abstract "A Bacillus subtilis mutant, that was selected for rifampin resistance produces spores with an altered morphology. The mutant spores are pleomorphic and differ both in shape and size from the wild-type spores. They frequently have an exosporium that is usually absent from wild-type spores. The mutant spores are similar to the wild-type spores in heat resistance, dipicolinic acid content, and density, but exhibit a slower rate of germination, outgrowth, and growth. In vitro studies show that the RNA polymerase of the mutant is resistant to rifampin inhibition, whereas the wild-type enzyme is completely inhibited by low concentrations of the antibiotic. Rifampin resistance and the altered spore morphology are contransformed with 100% frequency, suggesting that the altered morphology is caused by an alteration in the RNA polymerase." @default.
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• W2101214162 date "1970-06-01" @default.
• W2101214162 modified "2023-09-27" @default.
• W2101214162 title "<i>Bacillus subtilis</i> Mutant Altered in Spore Morphology and in RNA Polymerase Activity" @default.
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• W2101214162 doi "https://doi.org/10.1073/pnas.66.2.404" @default.
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