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- W2101221596 abstract "Background : Isoferulic acid (IFA) is a main active ingredient of the rhizoma of Cimicifuga heracleifolia , which is used frequently in Japanese traditional medicine as an anti-inflammatory drug. It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2 (MIP-2), which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells. Aim of the study : In this study, we investigated the therapeutic effect of IFA on the progression of lethal influenza virus pneumonia in mice by comparison with that of dexamethasone (DX), a potent inhibitor for various inflammatory cytokines including MIP-2. Methods : Mice were infected by intranasal inoculation of influenza virus under ether anesthesia. The IFA or DX was given by oral administration once daily for 4 days after infection. After infection, the survival rate and the change in body weight were daily monitored. Results : IFA administration markedly improved the survival rate and body weight loss of influenza virusinfected mice in a suitable dose range (0.5 mg/day). However, DX administration did not show a beneficial effect at any dose. Conclusion : These data suggested that IFA is a novel tool not only for the intervention therapy, but also for the studies on the pathogenesis of influenza virusinduced pneumonia." @default.
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- W2101221596 date "2001-01-01" @default.
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- W2101221596 title "Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice" @default.
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- W2101221596 doi "https://doi.org/10.1080/09629350120054572" @default.
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