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- W2101259868 abstract "In the inner ear, specificity of stimulus perception is achieved by associating the sensory epithelia of the three mechanoreceptor organs, the utricle/saccule, cristae, and cochlea, with distinct types of acellular matrices. Only the utricle and saccule have an extremely dense matrix, the otoconial complex, which overlies the sensory epithelium (macula) and provides inertial mass to generate shearing forces essential for the mechanoreceptors to sense gravity and linear acceleration. Such sensation is necessary for spatial orientation and balance. The importance of otoconia is clearly demonstrated by the impact of balance disorders upon the elderly population that involve otoconia degeneration, as well as by canalithiasis and cupulolithiasis, in which otoconia are dislocated. This underscores the need to understand how otoconia are formed and maintained and how to prevent their degeneration. To date, a number of otoconia-related proteins have been identified mostly in mice and bony fish. Although most of these proteins are also present in other structures of the inner ear, a distinct collection of proteins in the macula plus the unique ionic microenvironment of the endolymph near its epithelium likely contribute to the site-specific calcification of otoconia. Based on the current literature and ongoing research, this mini-review postulates a working model of how the otoconia complex is assembled specifically above the macular sensory epithelium of the vestibule. The central hypothesis of this model is that proteins are critical in sequestering calcium for crystallization in the calcium-poor endolymph. The review also sets forth some issues that need to be resolved in the future." @default.
- W2101259868 created "2016-06-24" @default.
- W2101259868 creator A5031180159 @default.
- W2101259868 creator A5042293682 @default.
- W2101259868 creator A5090040067 @default.
- W2101259868 date "2006-05-01" @default.
- W2101259868 modified "2023-10-02" @default.
- W2101259868 title "Assembly of the otoconia complex to the macular sensory epithelium of the vestibule" @default.
- W2101259868 cites W1440199104 @default.
- W2101259868 cites W1508237796 @default.
- W2101259868 cites W1521324513 @default.
- W2101259868 cites W1525038108 @default.
- W2101259868 cites W1551038041 @default.
- W2101259868 cites W1555095391 @default.
- W2101259868 cites W1562777847 @default.
- W2101259868 cites W162717576 @default.
- W2101259868 cites W1963560972 @default.
- W2101259868 cites W1967651171 @default.
- W2101259868 cites W1968860507 @default.
- W2101259868 cites W1971041510 @default.
- W2101259868 cites W1971047575 @default.
- W2101259868 cites W1975162635 @default.
- W2101259868 cites W1976334353 @default.
- W2101259868 cites W1977202177 @default.
- W2101259868 cites W1977766542 @default.
- W2101259868 cites W1984931573 @default.
- W2101259868 cites W1985405662 @default.
- W2101259868 cites W1986106831 @default.
- W2101259868 cites W1988786406 @default.
- W2101259868 cites W1990742057 @default.
- W2101259868 cites W1991040613 @default.
- W2101259868 cites W1991760840 @default.
- W2101259868 cites W1996789388 @default.
- W2101259868 cites W1997437715 @default.
- W2101259868 cites W2001497714 @default.
- W2101259868 cites W2002592620 @default.
- W2101259868 cites W2005376475 @default.
- W2101259868 cites W2006906257 @default.
- W2101259868 cites W2006982649 @default.
- W2101259868 cites W2008208203 @default.
- W2101259868 cites W2008672605 @default.
- W2101259868 cites W2009277094 @default.
- W2101259868 cites W2010059326 @default.
- W2101259868 cites W2011172963 @default.
- W2101259868 cites W2013935392 @default.
- W2101259868 cites W2015426937 @default.
- W2101259868 cites W2019698312 @default.
- W2101259868 cites W2020173390 @default.
- W2101259868 cites W2022761747 @default.
- W2101259868 cites W2023872285 @default.
- W2101259868 cites W2025790095 @default.
- W2101259868 cites W2026370897 @default.
- W2101259868 cites W2027129700 @default.
- W2101259868 cites W2028448785 @default.
- W2101259868 cites W2034474046 @default.
- W2101259868 cites W2035076409 @default.
- W2101259868 cites W2037822540 @default.
- W2101259868 cites W2038624289 @default.
- W2101259868 cites W2040824994 @default.
- W2101259868 cites W2043211010 @default.
- W2101259868 cites W2049407599 @default.
- W2101259868 cites W2049998619 @default.
- W2101259868 cites W2057397798 @default.
- W2101259868 cites W2057527963 @default.
- W2101259868 cites W2062451155 @default.
- W2101259868 cites W2063238745 @default.
- W2101259868 cites W2063785352 @default.
- W2101259868 cites W2065987736 @default.
- W2101259868 cites W2070076361 @default.
- W2101259868 cites W2073840612 @default.
- W2101259868 cites W2076984225 @default.
- W2101259868 cites W2078714496 @default.
- W2101259868 cites W2078867880 @default.
- W2101259868 cites W2080338272 @default.
- W2101259868 cites W2080398188 @default.
- W2101259868 cites W2081357244 @default.
- W2101259868 cites W2081504244 @default.
- W2101259868 cites W2086370712 @default.
- W2101259868 cites W2089820416 @default.
- W2101259868 cites W2097932424 @default.
- W2101259868 cites W2098726454 @default.
- W2101259868 cites W2099669252 @default.
- W2101259868 cites W2108761502 @default.
- W2101259868 cites W2109868881 @default.
- W2101259868 cites W2124605764 @default.
- W2101259868 cites W2135401179 @default.
- W2101259868 cites W2136220801 @default.
- W2101259868 cites W2141614367 @default.
- W2101259868 cites W2153527056 @default.
- W2101259868 cites W2154412075 @default.
- W2101259868 cites W2161615911 @default.
- W2101259868 cites W2165382801 @default.
- W2101259868 cites W2167499158 @default.
- W2101259868 cites W2231367964 @default.
- W2101259868 cites W2314605608 @default.
- W2101259868 cites W29366017 @default.
- W2101259868 doi "https://doi.org/10.1016/j.brainres.2006.02.083" @default.
- W2101259868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16600187" @default.