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• W2101301747 abstract "Abstract Naturally evolving proteins gradually accumulate mutations while continuing to fold to stable structures. This process of neutral evolution is an important mode of genetic change and forms the basis for the molecular clock. We present a mathematical theory that predicts the number of accumulated mutations, the index of dispersion, and the distribution of stabilities in an evolving protein population from knowledge of the stability effects (ΔΔG values) for single mutations. Our theory quantitatively describes how neutral evolution leads to marginally stable proteins and provides formulas for calculating how fluctuations in stability can overdisperse the molecular clock. It also shows that the structural influences on the rate of sequence evolution observed in earlier simulations can be calculated using just the single-mutation ΔΔG values. We consider both the case when the product of the population size and mutation rate is small and the case when this product is large, and show that in the latter case the proteins evolve excess mutational robustness that is manifested by extra stability and an increase in the rate of sequence evolution. All our theoretical predictions are confirmed by simulations with lattice proteins. Our work provides a mathematical foundation for understanding how protein biophysics shapes the process of evolution." @default.
• W2101301747 created "2016-06-24" @default.
• W2101301747 creator A5009586817 @default.
• W2101301747 creator A5070411498 @default.
• W2101301747 creator A5091068534 @default.
• W2101301747 date "2007-01-01" @default.
• W2101301747 modified "2023-10-17" @default.
• W2101301747 title "Thermodynamics of Neutral Protein Evolution" @default.
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• W2101301747 doi "https://doi.org/10.1534/genetics.106.061754" @default.
• W2101301747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1775007" @default.
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