Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101311724> ?p ?o ?g. }
- W2101311724 endingPage "587" @default.
- W2101311724 startingPage "581" @default.
- W2101311724 abstract "This study was performed to test the hypothesis that administration of recombinant human erythropoietin (rHuEpo) in humans increases maximal oxygen consumption by augmenting the maximal oxygen carrying capacity of blood. Systemic and leg oxygen delivery and oxygen uptake were studied during exercise in eight subjects before and after 13 wk of rHuEpo treatment and after isovolemic hemodilution to the same hemoglobin concentration observed before the start of rHuEpo administration. At peak exercise, leg oxygen delivery was increased from 1,777.0 ± 102.0 ml/min before rHuEpo treatment to 2,079.8 ± 120.7 ml/min after treatment. After hemodilution, oxygen delivery was decreased to the pretreatment value (1,710.3 ± 138.1 ml/min). Fractional leg arterial oxygen extraction was unaffected at maximal exercise; hence, maximal leg oxygen uptake increased from 1,511.0 ± 130.1 ml/min before treatment to 1,793.0 ± 148.7 ml/min with rHuEpo and decreased after hemodilution to 1,428.0 ± 111.6 ml/min. Pulmonary oxygen uptake at peak exercise increased from 3,950.0 ± 160.7 before administration to 4,254.5 ± 178.4 ml/min with rHuEpo and decreased to 4,059.0 ± 161.1 ml/min with hemodilution ( P = 0.22, compared with values before rHuEpo treatment). Blood buffer capacity remained unaffected by rHuEpo treatment and hemodilution. The augmented hematocrit did not compromise peak cardiac output. In summary, in healthy humans, rHuEpo increases maximal oxygen consumption due to augmented systemic and muscular peak oxygen delivery." @default.
- W2101311724 created "2016-06-24" @default.
- W2101311724 creator A5005926479 @default.
- W2101311724 creator A5017102452 @default.
- W2101311724 creator A5022335309 @default.
- W2101311724 creator A5033827870 @default.
- W2101311724 creator A5061968472 @default.
- W2101311724 creator A5066850019 @default.
- W2101311724 creator A5073127932 @default.
- W2101311724 date "2008-08-01" @default.
- W2101311724 modified "2023-10-16" @default.
- W2101311724 title "Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?" @default.
- W2101311724 cites W1516182718 @default.
- W2101311724 cites W1915125682 @default.
- W2101311724 cites W1966560678 @default.
- W2101311724 cites W1967109168 @default.
- W2101311724 cites W1972307989 @default.
- W2101311724 cites W1978495288 @default.
- W2101311724 cites W1980734940 @default.
- W2101311724 cites W1989820240 @default.
- W2101311724 cites W2012064235 @default.
- W2101311724 cites W2021823221 @default.
- W2101311724 cites W2027661084 @default.
- W2101311724 cites W2031464795 @default.
- W2101311724 cites W2034256529 @default.
- W2101311724 cites W2034881005 @default.
- W2101311724 cites W2062931296 @default.
- W2101311724 cites W2074243670 @default.
- W2101311724 cites W2075226747 @default.
- W2101311724 cites W2083484030 @default.
- W2101311724 cites W2084661996 @default.
- W2101311724 cites W2104548760 @default.
- W2101311724 cites W2121924895 @default.
- W2101311724 cites W2124880827 @default.
- W2101311724 cites W2128157205 @default.
- W2101311724 cites W2130675876 @default.
- W2101311724 cites W2133498153 @default.
- W2101311724 cites W2133768260 @default.
- W2101311724 cites W2136491991 @default.
- W2101311724 cites W2140654407 @default.
- W2101311724 cites W2143058635 @default.
- W2101311724 cites W2167973059 @default.
- W2101311724 cites W2255086557 @default.
- W2101311724 cites W2263602363 @default.
- W2101311724 cites W2401727061 @default.
- W2101311724 cites W2875790147 @default.
- W2101311724 cites W84675279 @default.
- W2101311724 doi "https://doi.org/10.1152/japplphysiol.90484.2008" @default.
- W2101311724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18535134" @default.
- W2101311724 hasPublicationYear "2008" @default.
- W2101311724 type Work @default.
- W2101311724 sameAs 2101311724 @default.
- W2101311724 citedByCount "82" @default.
- W2101311724 countsByYear W21013117242012 @default.
- W2101311724 countsByYear W21013117242013 @default.
- W2101311724 countsByYear W21013117242014 @default.
- W2101311724 countsByYear W21013117242015 @default.
- W2101311724 countsByYear W21013117242016 @default.
- W2101311724 countsByYear W21013117242017 @default.
- W2101311724 countsByYear W21013117242018 @default.
- W2101311724 countsByYear W21013117242019 @default.
- W2101311724 countsByYear W21013117242020 @default.
- W2101311724 countsByYear W21013117242021 @default.
- W2101311724 countsByYear W21013117242022 @default.
- W2101311724 countsByYear W21013117242023 @default.
- W2101311724 crossrefType "journal-article" @default.
- W2101311724 hasAuthorship W2101311724A5005926479 @default.
- W2101311724 hasAuthorship W2101311724A5017102452 @default.
- W2101311724 hasAuthorship W2101311724A5022335309 @default.
- W2101311724 hasAuthorship W2101311724A5033827870 @default.
- W2101311724 hasAuthorship W2101311724A5061968472 @default.
- W2101311724 hasAuthorship W2101311724A5066850019 @default.
- W2101311724 hasAuthorship W2101311724A5073127932 @default.
- W2101311724 hasBestOaLocation W21013117242 @default.
- W2101311724 hasConcept C126322002 @default.
- W2101311724 hasConcept C139940330 @default.
- W2101311724 hasConcept C178790620 @default.
- W2101311724 hasConcept C178853913 @default.
- W2101311724 hasConcept C185592680 @default.
- W2101311724 hasConcept C196310339 @default.
- W2101311724 hasConcept C2777953023 @default.
- W2101311724 hasConcept C2778534260 @default.
- W2101311724 hasConcept C2778917026 @default.
- W2101311724 hasConcept C2780959883 @default.
- W2101311724 hasConcept C2993864201 @default.
- W2101311724 hasConcept C42219234 @default.
- W2101311724 hasConcept C540031477 @default.
- W2101311724 hasConcept C71924100 @default.
- W2101311724 hasConcept C84393581 @default.
- W2101311724 hasConceptScore W2101311724C126322002 @default.
- W2101311724 hasConceptScore W2101311724C139940330 @default.
- W2101311724 hasConceptScore W2101311724C178790620 @default.
- W2101311724 hasConceptScore W2101311724C178853913 @default.
- W2101311724 hasConceptScore W2101311724C185592680 @default.
- W2101311724 hasConceptScore W2101311724C196310339 @default.
- W2101311724 hasConceptScore W2101311724C2777953023 @default.
- W2101311724 hasConceptScore W2101311724C2778534260 @default.
- W2101311724 hasConceptScore W2101311724C2778917026 @default.