FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101340409> ?p ?o ?g. }

• W2101340409 abstract "The activity of the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E4><mml:mi>β</mml:mi></mml:math>-cell<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E5><mml:msup><mml:mtext>Na</mml:mtext><mml:mo>+</mml:mo></mml:msup><mml:mo>/</mml:mo><mml:msup><mml:mtext>k</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>pump was studied by using ouabain-sensitive (lmM ouabain)<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E6><mml:mmultiscripts><mml:mtext>R</mml:mtext><mml:mprescripts /><mml:none /><mml:mrow><mml:mn>86</mml:mn></mml:mrow></mml:mmultiscripts><mml:msup><mml:mtext>b</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>influx in<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E7><mml:mi>β</mml:mi></mml:math>-cell-rich islets of Umeå- ob/ob mice as an indicator of the pump function. The present results show that the stimulatory effect of glucose on ouabain-sensitive<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E8><mml:mmultiscripts><mml:mtext>R</mml:mtext><mml:mprescripts /><mml:none /><mml:mrow><mml:mn>86</mml:mn></mml:mrow></mml:mmultiscripts><mml:msup><mml:mtext>b</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>influx reached its approximate maximum at 5mM glucose. Pre-treatment of the islets with 20mM glucose for 60 min strongly reduced the glucose-induced stimulation of the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E9><mml:msup><mml:mtext>Na</mml:mtext><mml:mo>+</mml:mo></mml:msup><mml:mo>/</mml:mo><mml:msup><mml:mtext>k</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>pump. Pre-treatment (60 or 180 min) of islets at 0mM glucose, on the other hand, did not affect the magnitude of the glucose-induced stimulation of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E10><mml:mmultiscripts><mml:mtext>R</mml:mtext><mml:mprescripts /><mml:none /><mml:mrow><mml:mn>86</mml:mn></mml:mrow></mml:mmultiscripts><mml:msup><mml:mtext>b</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>influx dunng the subsequent 5-min incubation. Glibenclamide stimulated the ouabain-sensitive<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E11><mml:mmultiscripts><mml:mtext>R</mml:mtext><mml:mprescripts /><mml:none /><mml:mrow><mml:mn>86</mml:mn></mml:mrow></mml:mmultiscripts><mml:msup><mml:mtext>b</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>uptake in the same manner as glucose. The stimulatory effect, showed its apparent maximum at 0.5μM. Pre-treatment (60 min) of islets with 1μM glibenclamide did not reduce the subsequent stimulation of the ouabain-sensitive<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E12><mml:mmultiscripts><mml:mtext>R</mml:mtext><mml:mprescripts /><mml:none /><mml:mrow><mml:mn>86</mml:mn></mml:mrow></mml:mmultiscripts><mml:msup><mml:mtext>b</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>influx. The stimulatory effect of glibenclamide and D-glucose were not .additive, suggesting that they may have the same mechanism of action. No direct effect of glibenclamide (0.01-1μM) was observed on the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E13><mml:msup><mml:mtext>Na</mml:mtext><mml:mo>+</mml:mo></mml:msup><mml:mo>/</mml:mo><mml:msup><mml:mtext>k</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>ATPase activity in homogenates of islets. Diazoxide (0.4mM) inhibited the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E14><mml:msup><mml:mtext>Na</mml:mtext><mml:mo>+</mml:mo></mml:msup><mml:mo>/</mml:mo><mml:msup><mml:mtext>k</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>pump. This effect was sustained even after 60 min of pre-treatment of islets with 0.4mM diazoxide. The stimulatory effect of glibenclamide and D-glucose were abolished by diazoxide. It is concluded that nutrient as well as non-nutrient insulin secretagogues activate the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E15><mml:msup><mml:mtext>Na</mml:mtext><mml:mo>+</mml:mo></mml:msup><mml:mo>/</mml:mo><mml:msup><mml:mtext>k</mml:mtext><mml:mo>+</mml:mo></mml:msup></mml:math>pump, probably as part of the membrane repolarisation process." @default.
• W2101340409 created "2016-06-24" @default.
• W2101340409 creator A5030356944 @default.
• W2101340409 creator A5031993779 @default.
• W2101340409 creator A5087531626 @default.
• W2101340409 date "2000-01-01" @default.
• W2101340409 modified "2023-10-18" @default.
• W2101340409 title "Modulation ofβ-Cell Ouabain-SensitiveR86b+Influx (Na+/k+Pump) by D-Glucose, Glibenclamide or Diazoxide" @default.
• W2101340409 cites W1800643727 @default.
• W2101340409 cites W1879913445 @default.
• W2101340409 cites W1963789558 @default.
• W2101340409 cites W1966862705 @default.
• W2101340409 cites W1967190464 @default.
• W2101340409 cites W1967307504 @default.
• W2101340409 cites W1976552734 @default.
• W2101340409 cites W1989298035 @default.
• W2101340409 cites W1990673560 @default.
• W2101340409 cites W1992045485 @default.
• W2101340409 cites W1993950831 @default.
• W2101340409 cites W1994924615 @default.
• W2101340409 cites W2001193614 @default.
• W2101340409 cites W2005150634 @default.
• W2101340409 cites W2009087988 @default.
• W2101340409 cites W2018273389 @default.
• W2101340409 cites W2062007901 @default.
• W2101340409 cites W2062915818 @default.
• W2101340409 cites W2068753297 @default.
• W2101340409 cites W2072682349 @default.
• W2101340409 cites W2074306054 @default.
• W2101340409 cites W2074342873 @default.
• W2101340409 cites W2074700213 @default.
• W2101340409 cites W2081682465 @default.
• W2101340409 cites W2089288966 @default.
• W2101340409 cites W2119652935 @default.
• W2101340409 cites W62613241 @default.
• W2101340409 doi "https://doi.org/10.1155/edr.2000.265" @default.
• W2101340409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2477744" @default.
• W2101340409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11467417" @default.
• W2101340409 hasPublicationYear "2000" @default.
• W2101340409 type Work @default.
• W2101340409 sameAs 2101340409 @default.
• W2101340409 citedByCount "8" @default.
• W2101340409 countsByYear W21013404092022 @default.
• W2101340409 crossrefType "journal-article" @default.
• W2101340409 hasAuthorship W2101340409A5030356944 @default.
• W2101340409 hasAuthorship W2101340409A5031993779 @default.
• W2101340409 hasAuthorship W2101340409A5087531626 @default.
• W2101340409 hasBestOaLocation W21013404091 @default.
• W2101340409 hasConcept C126322002 @default.
• W2101340409 hasConcept C134018914 @default.
• W2101340409 hasConcept C165220095 @default.
• W2101340409 hasConcept C171250308 @default.
• W2101340409 hasConcept C178790620 @default.
• W2101340409 hasConcept C185592680 @default.
• W2101340409 hasConcept C192562407 @default.
• W2101340409 hasConcept C24998067 @default.
• W2101340409 hasConcept C2776828364 @default.
• W2101340409 hasConcept C2779133857 @default.
• W2101340409 hasConcept C2779306644 @default.
• W2101340409 hasConcept C2779768347 @default.
• W2101340409 hasConcept C2779872217 @default.
• W2101340409 hasConcept C39271989 @default.
• W2101340409 hasConcept C537181965 @default.
• W2101340409 hasConcept C555293320 @default.
• W2101340409 hasConcept C71924100 @default.
• W2101340409 hasConcept C76272257 @default.
• W2101340409 hasConcept C83743174 @default.
• W2101340409 hasConcept C86803240 @default.
• W2101340409 hasConceptScore W2101340409C126322002 @default.
• W2101340409 hasConceptScore W2101340409C134018914 @default.
• W2101340409 hasConceptScore W2101340409C165220095 @default.
• W2101340409 hasConceptScore W2101340409C171250308 @default.
• W2101340409 hasConceptScore W2101340409C178790620 @default.
• W2101340409 hasConceptScore W2101340409C185592680 @default.
• W2101340409 hasConceptScore W2101340409C192562407 @default.
• W2101340409 hasConceptScore W2101340409C24998067 @default.
• W2101340409 hasConceptScore W2101340409C2776828364 @default.
• W2101340409 hasConceptScore W2101340409C2779133857 @default.
• W2101340409 hasConceptScore W2101340409C2779306644 @default.
• W2101340409 hasConceptScore W2101340409C2779768347 @default.
• W2101340409 hasConceptScore W2101340409C2779872217 @default.
• W2101340409 hasConceptScore W2101340409C39271989 @default.
• W2101340409 hasConceptScore W2101340409C537181965 @default.
• W2101340409 hasConceptScore W2101340409C555293320 @default.
• W2101340409 hasConceptScore W2101340409C71924100 @default.
• W2101340409 hasConceptScore W2101340409C76272257 @default.
• W2101340409 hasConceptScore W2101340409C83743174 @default.
• W2101340409 hasConceptScore W2101340409C86803240 @default.
• W2101340409 hasLocation W21013404091 @default.
• W2101340409 hasLocation W21013404092 @default.
• W2101340409 hasLocation W21013404093 @default.
• W2101340409 hasLocation W21013404094 @default.
• W2101340409 hasLocation W21013404095 @default.
• W2101340409 hasOpenAccess W2101340409 @default.
• W2101340409 hasPrimaryLocation W21013404091 @default.
• W2101340409 hasRelatedWork W1521076205 @default.
• W2101340409 hasRelatedWork W1991464954 @default.
• W2101340409 hasRelatedWork W2026669866 @default.
• W2101340409 hasRelatedWork W2033378058 @default.
• W2101340409 hasRelatedWork W2039643357 @default.

• next