FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101383225> ?p ?o ?g. }

• W2101383225 endingPage "705" @default.
• W2101383225 startingPage "696" @default.
• W2101383225 abstract "Abstract Previous work done in our laboratory, using mouse models, showed that soluble Fas ligand (sFasL) can efficiently delete donor anti-host T cells during their activation against irradiated host cells in MLCs. In the mouse models, this ex vivo sFasL treatment abrogated graft-vs-host disease (GVHD) while sparing donor T cells with antitumor reactivity. The present work was performed with human cells, to extend our work toward reduction of clinical GVHD. PBMC responders from a given individual (first party) were stimulated in vitro with irradiated PBMC stimulators from a second person (second party), in the presence of sFasL. In control MLCs without sFasL, alloreacting T cells began to up-regulate Fas (CD95) detectably and became sensitive to Fas-mediated apoptosis by as early as day 1–2. In MLCs containing sFasL, there were greatly reduced numbers of alloreacting CD3+CFSElo cells, activation Ag-expressing CD4hi and CD8hi cells, IFN-γ-producing CD4+ and CD8+ cells, and CD8+CD107a+ CTLs. Furthermore, mice transplanted with the ex vivo sFasL/MLR-treated cells had prolonged time to fatal GVHD in an in vivo xenogeneic GVHD model. Responder cells harvested from primary MLCs containing sFasL had reduced proliferation in response to second party cells, but proliferated in response to CMV Ags, PHA, and third party cells. In addition, sFasL/MLR-treated cell populations contained influenza-specific T cells, CD4+FOXP3+ T cells, and CD4+CD25+ T cells. These data indicate that this ex vivo sFasL/MLR depletion of alloreacting human donor anti-host T cells was efficient and selective." @default.
• W2101383225 created "2016-06-24" @default.
• W2101383225 creator A5006860649 @default.
• W2101383225 creator A5008240769 @default.
• W2101383225 creator A5039458471 @default.
• W2101383225 creator A5047214928 @default.
• W2101383225 creator A5048365527 @default.
• W2101383225 creator A5071883681 @default.
• W2101383225 date "2009-07-01" @default.
• W2101383225 modified "2023-10-04" @default.
• W2101383225 title "Selective Reduction of Graft-versus-Host Disease-Mediating Human T Cells by Ex Vivo Treatment with Soluble Fas Ligand" @default.
• W2101383225 cites W125081235 @default.
• W2101383225 cites W1482758361 @default.
• W2101383225 cites W1542615541 @default.
• W2101383225 cites W1964256375 @default.
• W2101383225 cites W1966516181 @default.
• W2101383225 cites W1967684158 @default.
• W2101383225 cites W1977209916 @default.
• W2101383225 cites W1984909066 @default.
• W2101383225 cites W1986374907 @default.
• W2101383225 cites W1989300385 @default.
• W2101383225 cites W1990863238 @default.
• W2101383225 cites W1993310853 @default.
• W2101383225 cites W2014888025 @default.
• W2101383225 cites W2019517733 @default.
• W2101383225 cites W2031398803 @default.
• W2101383225 cites W2033330275 @default.
• W2101383225 cites W2034838604 @default.
• W2101383225 cites W2036736974 @default.
• W2101383225 cites W2039198873 @default.
• W2101383225 cites W2039817295 @default.
• W2101383225 cites W2041027155 @default.
• W2101383225 cites W2041438140 @default.
• W2101383225 cites W2046414594 @default.
• W2101383225 cites W2047511312 @default.
• W2101383225 cites W2052531326 @default.
• W2101383225 cites W2058375486 @default.
• W2101383225 cites W2064252284 @default.
• W2101383225 cites W2068699102 @default.
• W2101383225 cites W2074181748 @default.
• W2101383225 cites W2074358174 @default.
• W2101383225 cites W2082032753 @default.
• W2101383225 cites W2085704445 @default.
• W2101383225 cites W2095466773 @default.
• W2101383225 cites W2098254750 @default.
• W2101383225 cites W2102236034 @default.
• W2101383225 cites W2102516973 @default.
• W2101383225 cites W2104294740 @default.
• W2101383225 cites W2110252464 @default.
• W2101383225 cites W2112041130 @default.
• W2101383225 cites W2115762631 @default.
• W2101383225 cites W2120028488 @default.
• W2101383225 cites W2137906256 @default.
• W2101383225 cites W2138402880 @default.
• W2101383225 cites W2145030204 @default.
• W2101383225 cites W2145254159 @default.
• W2101383225 cites W2146356855 @default.
• W2101383225 cites W2149936872 @default.
• W2101383225 cites W2154896319 @default.
• W2101383225 cites W2157325100 @default.
• W2101383225 cites W2157979692 @default.
• W2101383225 cites W2158114715 @default.
• W2101383225 cites W2159138189 @default.
• W2101383225 cites W2161239722 @default.
• W2101383225 cites W2166862028 @default.
• W2101383225 cites W2168740346 @default.
• W2101383225 cites W2262568580 @default.
• W2101383225 cites W2334996664 @default.
• W2101383225 cites W51816960 @default.
• W2101383225 doi "https://doi.org/10.4049/jimmunol.0800561" @default.
• W2101383225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3072680" @default.
• W2101383225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19535642" @default.
• W2101383225 hasPublicationYear "2009" @default.
• W2101383225 type Work @default.
• W2101383225 sameAs 2101383225 @default.
• W2101383225 citedByCount "27" @default.
• W2101383225 countsByYear W21013832252012 @default.
• W2101383225 countsByYear W21013832252013 @default.
• W2101383225 countsByYear W21013832252014 @default.
• W2101383225 countsByYear W21013832252015 @default.
• W2101383225 countsByYear W21013832252016 @default.
• W2101383225 countsByYear W21013832252017 @default.
• W2101383225 countsByYear W21013832252018 @default.
• W2101383225 countsByYear W21013832252020 @default.
• W2101383225 countsByYear W21013832252021 @default.
• W2101383225 countsByYear W21013832252023 @default.
• W2101383225 crossrefType "journal-article" @default.
• W2101383225 hasAuthorship W2101383225A5006860649 @default.
• W2101383225 hasAuthorship W2101383225A5008240769 @default.
• W2101383225 hasAuthorship W2101383225A5039458471 @default.
• W2101383225 hasAuthorship W2101383225A5047214928 @default.
• W2101383225 hasAuthorship W2101383225A5048365527 @default.
• W2101383225 hasAuthorship W2101383225A5071883681 @default.
• W2101383225 hasBestOaLocation W21013832251 @default.
• W2101383225 hasConcept C129374314 @default.
• W2101383225 hasConcept C137061746 @default.
• W2101383225 hasConcept C150903083 @default.
• W2101383225 hasConcept C154317977 @default.

• next