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- W2101392697 endingPage "998" @default.
- W2101392697 startingPage "988" @default.
- W2101392697 abstract "Myelin membrane synthesis in the CNS by oligodendrocytes (OLs) involves directed intracellular transport and targeting of copious amounts of specialized lipids and proteins over a relatively short time span. As in other plasma membrane-directed fusion, this process is expected to use specific trafficking and vesicle fusion proteins characteristic of the SNARE model. We have investigated the developmental expression of SNARE proteins in highly enriched primary cultures of OLs at discrete stages of differentiation. VAMP-2/synaptobrevin-2, syntaxin-2 and -4, nsec-1/munc-18-1, Rab3a, synaptophysin, and synapsin were expressed. During differentiation, expression of the vesicular SNARE VAMP-2, the small GTP-binding protein Rab3a, and the target SNARE syntaxin-4 were up-regulated. VAMP-2 and Rab3 proteins detected immunocytochemically in cultured OLs were localized within the developing process network; in situ anti-VAMP-2 antibody stained the perikarya of rows of cells with the distribution and appearance of OLs. We discuss the potential involvement of SNARE complex proteins in a plasma membrane-directed transport mechanism targeting nascent myelin vesicles to the forming myelin sheath." @default.
- W2101392697 created "2016-06-24" @default.
- W2101392697 creator A5027472835 @default.
- W2101392697 creator A5043300761 @default.
- W2101392697 creator A5044468051 @default.
- W2101392697 creator A5056714321 @default.
- W2101392697 creator A5077285080 @default.
- W2101392697 date "2008-07-07" @default.
- W2101392697 modified "2023-09-26" @default.
- W2101392697 title "SNARE Complex Proteins, Including the Cognate Pair VAMP-2and Syntaxin-4, Are Expressed in Cultured Oligodendrocytes" @default.
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- W2101392697 doi "https://doi.org/10.1046/j.1471-4159.1999.0720988.x" @default.
- W2101392697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10037470" @default.