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- W2101425156 endingPage "528" @default.
- W2101425156 startingPage "521" @default.
- W2101425156 abstract "Parkinson's disease (PD) is a neurodegenerative disease that is both common and incurable. The majority of cases are sporadic and of unknown origin but several genes have been identified that, when mutated, give rise to rare, familial forms of the disease. The principal genes that have been shown to cause PD are alpha-synuclein (SNCA), parkin, leucine-rich repeat kinase 2 (LRRK2), PTEN-induced putative kinase 1 (PINK1) and DJ-1. Here, we discuss what has been learnt from the study of these genes and what has been elucidated of the molecular pathways that lead to cell degeneration. Of importance is what these molecular events and pathways tell scientists of the common sporadic form of PD. Although complete knowledge of these genes' functions remains elusive, recent work implicates abnormal protein accumulation, protein phosphorylation, mitochondrial dysfunction and oxidative stress as common pathways to PD pathogenesis." @default.
- W2101425156 created "2016-06-24" @default.
- W2101425156 creator A5010708791 @default.
- W2101425156 creator A5017244515 @default.
- W2101425156 creator A5064529704 @default.
- W2101425156 date "2006-11-01" @default.
- W2101425156 modified "2023-10-01" @default.
- W2101425156 title "Understanding the molecular causes of Parkinson's disease" @default.
- W2101425156 cites W1496790952 @default.
- W2101425156 cites W1502551601 @default.
- W2101425156 cites W1521854746 @default.
- W2101425156 cites W1527671059 @default.
- W2101425156 cites W1550876205 @default.
- W2101425156 cites W1606762250 @default.
- W2101425156 cites W1877873625 @default.
- W2101425156 cites W1965398181 @default.
- W2101425156 cites W1972333969 @default.
- W2101425156 cites W1974208595 @default.
- W2101425156 cites W1974379210 @default.
- W2101425156 cites W1976316003 @default.
- W2101425156 cites W1976345822 @default.
- W2101425156 cites W1977069039 @default.
- W2101425156 cites W1979527613 @default.
- W2101425156 cites W1981063800 @default.
- W2101425156 cites W1982099803 @default.
- W2101425156 cites W1989522802 @default.
- W2101425156 cites W1991231925 @default.
- W2101425156 cites W1999469282 @default.
- W2101425156 cites W2004600163 @default.
- W2101425156 cites W2005385069 @default.
- W2101425156 cites W2010095758 @default.
- W2101425156 cites W2011977140 @default.
- W2101425156 cites W2017621114 @default.
- W2101425156 cites W2019006980 @default.
- W2101425156 cites W2020089945 @default.
- W2101425156 cites W2021097923 @default.
- W2101425156 cites W2021209363 @default.
- W2101425156 cites W2028806152 @default.
- W2101425156 cites W2033172620 @default.
- W2101425156 cites W2035609698 @default.
- W2101425156 cites W2036386995 @default.
- W2101425156 cites W2046014998 @default.
- W2101425156 cites W2046623850 @default.
- W2101425156 cites W2050849483 @default.
- W2101425156 cites W2052983466 @default.
- W2101425156 cites W2053840294 @default.
- W2101425156 cites W2055124287 @default.
- W2101425156 cites W2056725861 @default.
- W2101425156 cites W2058409097 @default.
- W2101425156 cites W2059261643 @default.
- W2101425156 cites W2061956914 @default.
- W2101425156 cites W2063127941 @default.
- W2101425156 cites W2066929651 @default.
- W2101425156 cites W2067346508 @default.
- W2101425156 cites W2071087722 @default.
- W2101425156 cites W2074085543 @default.
- W2101425156 cites W2074397899 @default.
- W2101425156 cites W2074649216 @default.
- W2101425156 cites W2085082653 @default.
- W2101425156 cites W2087389265 @default.
- W2101425156 cites W2088962120 @default.
- W2101425156 cites W2089206347 @default.
- W2101425156 cites W2091214947 @default.
- W2101425156 cites W2091507010 @default.
- W2101425156 cites W2100300726 @default.
- W2101425156 cites W2100872265 @default.
- W2101425156 cites W2100894616 @default.
- W2101425156 cites W2111542278 @default.
- W2101425156 cites W2114687743 @default.
- W2101425156 cites W2114881821 @default.
- W2101425156 cites W2123184492 @default.
- W2101425156 cites W2123431154 @default.
- W2101425156 cites W2125477506 @default.
- W2101425156 cites W2129755489 @default.
- W2101425156 cites W2129826948 @default.
- W2101425156 cites W2131641631 @default.
- W2101425156 cites W2134272142 @default.
- W2101425156 cites W2136388422 @default.
- W2101425156 cites W2140647923 @default.
- W2101425156 cites W2142286857 @default.
- W2101425156 cites W2142460292 @default.
- W2101425156 cites W2143161560 @default.
- W2101425156 cites W2144435948 @default.
- W2101425156 cites W2150656456 @default.
- W2101425156 cites W2151199043 @default.
- W2101425156 cites W2152330309 @default.
- W2101425156 cites W2154757569 @default.
- W2101425156 cites W2154761807 @default.
- W2101425156 cites W2158259597 @default.
- W2101425156 cites W2160484806 @default.
- W2101425156 cites W2161188071 @default.
- W2101425156 cites W2168941505 @default.
- W2101425156 cites W2171281715 @default.
- W2101425156 cites W2317804643 @default.
- W2101425156 cites W2019021459 @default.
- W2101425156 doi "https://doi.org/10.1016/j.molmed.2006.09.007" @default.
- W2101425156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17027339" @default.
- W2101425156 hasPublicationYear "2006" @default.