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- W2101451006 abstract "Patients with mechanical heart valves who present with intracranial haemorrhage are initially treated by reversing their coagulopathy. However, these patients will ultimately require that their oral anticoagulant be restarted. The time at which oral anticoagulants are restarted is critical since restarting too early may increase the risk of recurrent bleeding, while withholding anticoagulants increases the patient’s risk of thromboembolic events. The ideal time to restart patients on their oral anticoagulant medication is defined as the time at which all these risks are minimized.This thesis includes a systematic review and meta-analysis of the literature. The main outcomes were recurrent haematoma, valve thrombosis, stroke and peripheral emboli. Results were stratified by types of intracranial haemorrhage. We also conducted a survey to gain insight into current practices of neurosurgeons and thrombosis experts in Canada and USA when they are faced with deciding on anticoagulant restart times in patients with ICH. Results were stratified by type of intracranial bleed and participants’ characteristics and demographics.The systematic review identified that the ideal time for restarting anticoagulant therapy in patients following an ICH is unknown. Meta-analysis was limited by the heterogeneity of the studies.The survey results indicated that physicians had a wide range of practice and that their practice was dependent on the patient’s clinical features, but many physicians would restart oral anticoagulants between 4 and 14 days after the haemorrhage. For this reason we have proposed a multi centre cohort study to investigate the safety and efficacy of restarting patients on anticoagulation therapy between day 5 and 9 post haemorrhage. A full study protocol is presented in this thesis." @default.
- W2101451006 created "2016-06-24" @default.
- W2101451006 creator A5052509865 @default.
- W2101451006 date "2012-01-01" @default.
- W2101451006 modified "2023-09-27" @default.
- W2101451006 title "Restarting Oral Anticoagulant in Patients with Mechanical Heart Valve(s) and Intracranial Haemorrhage" @default.
- W2101451006 cites W108022464 @default.
- W2101451006 cites W129179199 @default.
- W2101451006 cites W1485542558 @default.
- W2101451006 cites W1486375251 @default.
- W2101451006 cites W1501172405 @default.
- W2101451006 cites W1509565492 @default.
- W2101451006 cites W1528770862 @default.
- W2101451006 cites W1531905043 @default.
- W2101451006 cites W1532814563 @default.
- W2101451006 cites W1533060560 @default.
- W2101451006 cites W1537448214 @default.
- W2101451006 cites W1539888920 @default.
- W2101451006 cites W1546967460 @default.
- W2101451006 cites W1559795939 @default.
- W2101451006 cites W1566155680 @default.
- W2101451006 cites W1580288159 @default.
- W2101451006 cites W1584034077 @default.
- W2101451006 cites W1590137713 @default.
- W2101451006 cites W1595368024 @default.
- W2101451006 cites W1598602811 @default.
- W2101451006 cites W1599551633 @default.
- W2101451006 cites W1603783125 @default.
- W2101451006 cites W1604269049 @default.
- W2101451006 cites W1606716760 @default.
- W2101451006 cites W160703130 @default.
- W2101451006 cites W1786915484 @default.
- W2101451006 cites W1816712423 @default.
- W2101451006 cites W1862091355 @default.
- W2101451006 cites W1914792350 @default.
- W2101451006 cites W1963502369 @default.
- W2101451006 cites W1964522360 @default.
- W2101451006 cites W1965052854 @default.
- W2101451006 cites W1966040064 @default.
- W2101451006 cites W1966062970 @default.
- W2101451006 cites W1967065569 @default.
- W2101451006 cites W1968332362 @default.
- W2101451006 cites W1969319080 @default.
- W2101451006 cites W1970935561 @default.
- W2101451006 cites W197199717 @default.
- W2101451006 cites W1975506997 @default.
- W2101451006 cites W1976133252 @default.
- W2101451006 cites W1979423827 @default.
- W2101451006 cites W1979485682 @default.
- W2101451006 cites W1980040441 @default.
- W2101451006 cites W1980693060 @default.
- W2101451006 cites W1981004829 @default.
- W2101451006 cites W1981194197 @default.
- W2101451006 cites W1981731367 @default.
- W2101451006 cites W1983926694 @default.
- W2101451006 cites W1984806670 @default.
- W2101451006 cites W1985563017 @default.
- W2101451006 cites W1986506316 @default.
- W2101451006 cites W1987904161 @default.
- W2101451006 cites W1992048941 @default.
- W2101451006 cites W1992147175 @default.
- W2101451006 cites W19932003 @default.
- W2101451006 cites W1993480970 @default.
- W2101451006 cites W1994337245 @default.
- W2101451006 cites W1996104453 @default.
- W2101451006 cites W1997996995 @default.
- W2101451006 cites W1998283363 @default.
- W2101451006 cites W1998697895 @default.
- W2101451006 cites W2000543807 @default.
- W2101451006 cites W2002470351 @default.
- W2101451006 cites W2003219143 @default.
- W2101451006 cites W2003911982 @default.
- W2101451006 cites W2004337162 @default.
- W2101451006 cites W2008176608 @default.
- W2101451006 cites W2008635765 @default.
- W2101451006 cites W2008891748 @default.
- W2101451006 cites W2010681181 @default.
- W2101451006 cites W2012273895 @default.
- W2101451006 cites W2012923240 @default.
- W2101451006 cites W2014927591 @default.
- W2101451006 cites W2015052105 @default.
- W2101451006 cites W2015592376 @default.
- W2101451006 cites W2015809256 @default.
- W2101451006 cites W2021866530 @default.
- W2101451006 cites W2022080618 @default.
- W2101451006 cites W2024664415 @default.
- W2101451006 cites W2029550334 @default.
- W2101451006 cites W2029553347 @default.
- W2101451006 cites W2031990245 @default.
- W2101451006 cites W2033072987 @default.
- W2101451006 cites W2033141506 @default.
- W2101451006 cites W2033840524 @default.
- W2101451006 cites W2034429879 @default.
- W2101451006 cites W2035386216 @default.
- W2101451006 cites W2037364602 @default.
- W2101451006 cites W2039528800 @default.
- W2101451006 cites W2040081091 @default.
- W2101451006 cites W2040317652 @default.
- W2101451006 cites W2040728381 @default.
- W2101451006 cites W2042687462 @default.