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• W2101453403 abstract "The molecular basis of cystic fibrosis (CF) is a mutation-related defect in the epithelial-cell chloride channel called CF transmembrane conductance regulator (CFTR). This defect alters chloride ion transport and impairs water transport across the cell membrane. Marked clinical heterogeneity occurs even among patients carrying the same mutation in the CFTR gene. Recent studies suggest that such heterogeneity could be related to epigenetic factors and/or miRNAs, which are small noncoding RNAs that modulate the expression of various proteins via post-transcriptional inhibition of gene expression. In the respiratory system, it has been shown that the dysregulation of miRNAs could participate in and lead to pathogenicity in several diseases. In CF airways, recent studies have proposed that miRNAs may modulate disease progression by affecting the production of either CFTR or various proteins that are dysregulated in the CF lung. Herein, we provide an overview of studies showing how miRNAs may modulate CF pathology and the efforts to develop miRNA-based treatments and/or to consider miRNAs as biomarkers. The identification of miRNAs involved in CF disease progression opens up new avenues toward treatments targeting selected clinical components of CF, independently from the CFTR mutation." @default.
• W2101453403 created "2016-06-24" @default.
• W2101453403 creator A5001025455 @default.
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• W2101453403 creator A5033744872 @default.
• W2101453403 creator A5050031893 @default.
• W2101453403 creator A5052110640 @default.
• W2101453403 date "2015-04-01" @default.
• W2101453403 modified "2023-10-13" @default.
• W2101453403 title "New Insights about miRNAs in Cystic Fibrosis" @default.
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