FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101457198> ?p ?o ?g. }

• W2101457198 endingPage "262" @default.
• W2101457198 startingPage "253" @default.
• W2101457198 abstract "ABSTRACT Background: Tibia fracture in rats evokes chronic hindpaw warmth, edema, allodynia, and regional osteopenia, a syndrome resembling complex regional pain syndrome (CRPS). Previous studies suggest that the pathogenesis of some of these changes involves an exaggerated regional inflammatory response to injury and we postulated that inflammatory cytokines contribute to the development of CRPS‐like changes after fracture. Methods: The distal tibia was fractured and the hindlimb casted for 4 weeks. The rats were given drinking water with or without the cytokine inhibitor pentoxifylline (PTX) starting the day before fracture and continuing for 4 weeks, after which time the cast was removed and multiple assays were performed in the hindpaw. PCR and immunoassays were used to evaluate changes in cytokine expression. Bilateral hindpaw thickness, temperature, and nociceptive thresholds were determined, and bone microarchitecture was measured by microcomputed tomography (μCT). Results: Tibia fracture chronically up‐regulated TNFα, IL‐1β and IL‐6 mRNA and protein levels in hindpaw skin and PTX treatment significantly reduced the mRNA expression and cytokine protein levels for all these cytokines. PTX inhibited the nociceptive sensitization and some vascular changes, but had insignificant effects on most of the bone‐related parameters measured in these studies. Immunostaining of hindpaw skin was negative for immunocyte infiltration at 4 weeks post‐fracture. Conclusions: These results suggest that pro‐inflammatory cytokines contribute to the nociceptive and vascular sequelae of fracture and that PTX treatment can reverse these CRPS‐like changes." @default.
• W2101457198 created "2016-06-24" @default.
• W2101457198 creator A5009208394 @default.
• W2101457198 creator A5020062882 @default.
• W2101457198 creator A5027575817 @default.
• W2101457198 creator A5048023375 @default.
• W2101457198 creator A5049621128 @default.
• W2101457198 creator A5056384169 @default.
• W2101457198 creator A5059918913 @default.
• W2101457198 creator A5068362625 @default.
• W2101457198 creator A5069008709 @default.
• W2101457198 creator A5089086027 @default.
• W2101457198 date "2009-03-01" @default.
• W2101457198 modified "2023-10-18" @default.
• W2101457198 title "Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome" @default.
• W2101457198 cites W1482682744 @default.
• W2101457198 cites W1523595999 @default.
• W2101457198 cites W1571192847 @default.
• W2101457198 cites W1571249042 @default.
• W2101457198 cites W1843382282 @default.
• W2101457198 cites W1902683402 @default.
• W2101457198 cites W1968515077 @default.
• W2101457198 cites W1973261188 @default.
• W2101457198 cites W1973439033 @default.
• W2101457198 cites W1976024859 @default.
• W2101457198 cites W1979228328 @default.
• W2101457198 cites W1979932846 @default.
• W2101457198 cites W1983162823 @default.
• W2101457198 cites W1985734972 @default.
• W2101457198 cites W1989103258 @default.
• W2101457198 cites W1990378054 @default.
• W2101457198 cites W1991663906 @default.
• W2101457198 cites W1999929353 @default.
• W2101457198 cites W2001699192 @default.
• W2101457198 cites W2006193913 @default.
• W2101457198 cites W2007960206 @default.
• W2101457198 cites W2008810483 @default.
• W2101457198 cites W2008882321 @default.
• W2101457198 cites W2012032810 @default.
• W2101457198 cites W2012701523 @default.
• W2101457198 cites W2014767524 @default.
• W2101457198 cites W2021043915 @default.
• W2101457198 cites W2024456541 @default.
• W2101457198 cites W2030568628 @default.
• W2101457198 cites W2031375858 @default.
• W2101457198 cites W2033634651 @default.
• W2101457198 cites W2036655305 @default.
• W2101457198 cites W2041008164 @default.
• W2101457198 cites W2041591721 @default.
• W2101457198 cites W2043141738 @default.
• W2101457198 cites W2057679641 @default.
• W2101457198 cites W2062436855 @default.
• W2101457198 cites W2062697678 @default.
• W2101457198 cites W2065432788 @default.
• W2101457198 cites W2065447230 @default.
• W2101457198 cites W2066294954 @default.
• W2101457198 cites W2070043197 @default.
• W2101457198 cites W2096842237 @default.
• W2101457198 cites W2101191242 @default.
• W2101457198 cites W2102546684 @default.
• W2101457198 cites W2107866503 @default.
• W2101457198 cites W2139996507 @default.
• W2101457198 cites W2146308879 @default.
• W2101457198 cites W2152077121 @default.
• W2101457198 cites W2158396577 @default.
• W2101457198 cites W2161697663 @default.
• W2101457198 cites W2161978350 @default.
• W2101457198 cites W2164665357 @default.
• W2101457198 cites W2171204926 @default.
• W2101457198 cites W2185164773 @default.
• W2101457198 cites W2231489492 @default.
• W2101457198 cites W2963601092 @default.
• W2101457198 cites W4211024532 @default.
• W2101457198 cites W4236640470 @default.
• W2101457198 cites W4245868295 @default.
• W2101457198 doi "https://doi.org/10.1016/j.ejpain.2008.04.014" @default.
• W2101457198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2673487" @default.
• W2101457198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18554967" @default.
• W2101457198 hasPublicationYear "2009" @default.
• W2101457198 type Work @default.
• W2101457198 sameAs 2101457198 @default.
• W2101457198 citedByCount "61" @default.
• W2101457198 countsByYear W21014571982012 @default.
• W2101457198 countsByYear W21014571982013 @default.
• W2101457198 countsByYear W21014571982014 @default.
• W2101457198 countsByYear W21014571982015 @default.
• W2101457198 countsByYear W21014571982016 @default.
• W2101457198 countsByYear W21014571982017 @default.
• W2101457198 countsByYear W21014571982018 @default.
• W2101457198 countsByYear W21014571982019 @default.
• W2101457198 countsByYear W21014571982020 @default.
• W2101457198 countsByYear W21014571982021 @default.
• W2101457198 countsByYear W21014571982022 @default.
• W2101457198 countsByYear W21014571982023 @default.
• W2101457198 crossrefType "journal-article" @default.
• W2101457198 hasAuthorship W2101457198A5009208394 @default.
• W2101457198 hasAuthorship W2101457198A5020062882 @default.
• W2101457198 hasAuthorship W2101457198A5027575817 @default.

• next