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- W2101460178 endingPage "R203" @default.
- W2101460178 startingPage "R197" @default.
- W2101460178 abstract "Genetic variation in the regulation of gene expression is likely to be a major contributor to phenotypic variation in humans, and it also constitutes an important target of recent natural selection in human populations and plays a major role in morphological evolution. The increasing amount of data of genome and transcriptome variation is now leading to a better annotation of regulatory elements and a growing understanding of how the evolution of gene regulation has shaped human diversity. In this review, we discuss the evolutionary history of the variation in the expression of protein-coding genes in humans. We outline the current methodology for mapping regulatory variants and their distribution in human populations. General mechanisms of regulatory evolution are discussed with a special emphasis on different selective processes targeting gene regulation in humans." @default.
- W2101460178 created "2016-06-24" @default.
- W2101460178 creator A5064165945 @default.
- W2101460178 creator A5084258150 @default.
- W2101460178 date "2010-09-28" @default.
- W2101460178 modified "2023-10-16" @default.
- W2101460178 title "Evolutionary history of regulatory variation in human populations" @default.
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