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• W2101471090 abstract "Abstract: Stage‐specific expression of a number of cell‐surface and signaling proteins is critical for normal development of T cells in the thymus. Equally important may be the loss of expression/signaling of developmentally regulated proteins for proper transitioning of developing T cells into thymic subsets. Ly‐6A.2 exhibits a regulated pattern of expression on T cells maturing in the thymus, and dysregulating its expression results in arrest of developing T cells within the CD3 − CD4 − CD8 − triple negative (TN) stage where the normal expression of Ly‐6A.2 is extinguished. To further characterize the mechanisms underlying this block, we examined whether cell signaling and/or cell adhesion properties of the Ly‐6A.2 molecule influenced the block in T‐cell development. Analysis of bone marrow chimeras generated by injecting CFSE‐labeled Ly‐6A.2 transgenic bone marrow cells into irradiated syngeneic non‐transgenic mice revealed normal trafficking of developing T cells from the cortex into the medulla. Production of LAT but not p56 lck was diminished in CD4 − CD8 − DN cells from Ly‐6A.2 dysregulated mice when compared with control littermates. Dysregulated expression of Ly‐6A.2 did not suppress endogenous TCR‐V β expression. Finally, dysregulated expression of Ly‐6A.2 enhanced apoptosis of an immature CD4 + CD8 + (DP) subset of developing cells and altered the selected TCR‐V β repertoire. Taken together, these observations indicate that the termination of Ly‐6A.2 expression and signaling within the CD4 − CD8 − CD3 − subset of developing T cells is an important checkpoint during normal thymic development." @default.
• W2101471090 created "2016-06-24" @default.
• W2101471090 creator A5052791946 @default.
• W2101471090 creator A5078604033 @default.
• W2101471090 date "2003-07-30" @default.
• W2101471090 modified "2023-10-15" @default.
• W2101471090 title "Loss of Ly-6A.2 expression on immature developing T cells in the thymus is necessary for their normal growth and generation of the Vβ T-cell repertoire" @default.
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• W2101471090 doi "https://doi.org/10.1034/j.1399-0039.2003.00063.x" @default.
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• W2101471090 hasPublicationYear "2003" @default.
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