Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101471525> ?p ?o ?g. }
- W2101471525 endingPage "224" @default.
- W2101471525 startingPage "224" @default.
- W2101471525 abstract "As the cellular component of articular cartilage, chondrocytes are responsible for maintaining in a low-turnover state the unique composition and organization of the matrix that was determined during embryonic and postnatal development. In joint diseases, cartilage homeostasis is disrupted by mechanisms that are driven by combinations of biological mediators that vary according to the disease process, including contributions from other joint tissues. In osteoarthritis (OA), biomechanical stimuli predominate with up-regulation of both catabolic and anabolic cytokines and recapitulation of developmental phenotypes, whereas in rheumatoid arthritis (RA), inflammation and catabolism drive cartilage loss. In vitro studies in chondrocytes have elucidated signaling pathways and transcription factors that orchestrate specific functions that promote cartilage damage in both OA and RA. Thus, understanding how the adult articular chondrocyte functions within its unique environment will aid in the development of rational strategies to protect cartilage from damage resulting from joint disease. This review will cover current knowledge about the specific cellular and biochemical mechanisms that regulate cartilage homeostasis and pathology." @default.
- W2101471525 created "2016-06-24" @default.
- W2101471525 creator A5009342847 @default.
- W2101471525 creator A5080253242 @default.
- W2101471525 date "2009-01-01" @default.
- W2101471525 modified "2023-10-05" @default.
- W2101471525 title "Cartilage homeostasis in health and rheumatic diseases" @default.
- W2101471525 cites W120944073 @default.
- W2101471525 cites W1493844743 @default.
- W2101471525 cites W1502939644 @default.
- W2101471525 cites W1541137078 @default.
- W2101471525 cites W1558609475 @default.
- W2101471525 cites W1568585026 @default.
- W2101471525 cites W1606976518 @default.
- W2101471525 cites W1774678646 @default.
- W2101471525 cites W1800240952 @default.
- W2101471525 cites W1828014100 @default.
- W2101471525 cites W1850400028 @default.
- W2101471525 cites W192836234 @default.
- W2101471525 cites W1964030362 @default.
- W2101471525 cites W1965245788 @default.
- W2101471525 cites W1966725283 @default.
- W2101471525 cites W1967494982 @default.
- W2101471525 cites W1969148503 @default.
- W2101471525 cites W1969498803 @default.
- W2101471525 cites W1970693983 @default.
- W2101471525 cites W1970850706 @default.
- W2101471525 cites W1971211678 @default.
- W2101471525 cites W1972359049 @default.
- W2101471525 cites W1973031081 @default.
- W2101471525 cites W1973619540 @default.
- W2101471525 cites W1974307085 @default.
- W2101471525 cites W1975523013 @default.
- W2101471525 cites W1976089856 @default.
- W2101471525 cites W1976553002 @default.
- W2101471525 cites W1980403364 @default.
- W2101471525 cites W1980613658 @default.
- W2101471525 cites W1983345459 @default.
- W2101471525 cites W1983529894 @default.
- W2101471525 cites W1983579606 @default.
- W2101471525 cites W1984186264 @default.
- W2101471525 cites W1984350356 @default.
- W2101471525 cites W1984367241 @default.
- W2101471525 cites W1986409534 @default.
- W2101471525 cites W1986442052 @default.
- W2101471525 cites W1987809177 @default.
- W2101471525 cites W1988760613 @default.
- W2101471525 cites W1989070021 @default.
- W2101471525 cites W1990371560 @default.
- W2101471525 cites W1990750207 @default.
- W2101471525 cites W1990844960 @default.
- W2101471525 cites W1993178967 @default.
- W2101471525 cites W1995276823 @default.
- W2101471525 cites W1996939391 @default.
- W2101471525 cites W1998621808 @default.
- W2101471525 cites W1999013968 @default.
- W2101471525 cites W1999249821 @default.
- W2101471525 cites W1999706179 @default.
- W2101471525 cites W1999775304 @default.
- W2101471525 cites W2000016264 @default.
- W2101471525 cites W2000639850 @default.
- W2101471525 cites W2001436617 @default.
- W2101471525 cites W2001856721 @default.
- W2101471525 cites W2002250615 @default.
- W2101471525 cites W2002251686 @default.
- W2101471525 cites W2004793594 @default.
- W2101471525 cites W2005832407 @default.
- W2101471525 cites W2006113653 @default.
- W2101471525 cites W2006191064 @default.
- W2101471525 cites W2008246498 @default.
- W2101471525 cites W2011227409 @default.
- W2101471525 cites W2011446543 @default.
- W2101471525 cites W2013064709 @default.
- W2101471525 cites W2013607742 @default.
- W2101471525 cites W2013970253 @default.
- W2101471525 cites W2014041075 @default.
- W2101471525 cites W2015354603 @default.
- W2101471525 cites W2016251547 @default.
- W2101471525 cites W2016892864 @default.
- W2101471525 cites W2016931709 @default.
- W2101471525 cites W2017268676 @default.
- W2101471525 cites W2017917715 @default.
- W2101471525 cites W2018172685 @default.
- W2101471525 cites W2019213708 @default.
- W2101471525 cites W2019278201 @default.
- W2101471525 cites W2020013524 @default.
- W2101471525 cites W2020963294 @default.
- W2101471525 cites W2022468416 @default.
- W2101471525 cites W2022494133 @default.
- W2101471525 cites W2024553518 @default.
- W2101471525 cites W2026245214 @default.
- W2101471525 cites W2030044728 @default.
- W2101471525 cites W2030165321 @default.
- W2101471525 cites W2034251584 @default.
- W2101471525 cites W2035636765 @default.
- W2101471525 cites W2036123458 @default.
- W2101471525 cites W2038975231 @default.
- W2101471525 cites W2039218254 @default.