FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2101472374> ?p ?o ?g. }

• W2101472374 endingPage "701" @default.
• W2101472374 startingPage "695" @default.
• W2101472374 abstract "The complex nature of hypertension makes identifying the pathophysiology and its genetic contributions a challenging task. One powerful approach for the genetic dissection of blood pressure regulation is studying inbred rat models of hypertension, as they provide natural allele variants but reduced heterogeneity (both genetic and etiologic). Furthermore, the detailed physiologic studies to which the rat is amenable allow for the determination of intermediate phenotypes. We have performed a total genome scan in offspring of an F 2 intercross between the Lyon hypertensive (LH) and Lyon normotensive rat strains to identify linkage of anthropometric, blood pressure, renal, metabolic, and endocrine phenotypes. Quantitative trait locus (QTL) regions involved in blood pressure regulation, end-stage organ damage, body and organ weight, and lipid metabolism in the LH rat were identified on chromosomes 1, 2, 3, 5, 7, 10, 13, and 17, with 2 phenotypes associated with the metabolic syndrome identified on chromosomes 1 and 17. Regions on chromosomes 2, 13, and 17 were revealed to be important for blood pressure regulation. Regions on chromosome 17 were found to significantly contribute to both metabolic homeostasis and blood pressure regulation; 2 aggregates of a total of 23 QTLs were identified, including several “intermediate phenotypes.” These intermediate phenotypes may be used as closer surrogates to the mechanisms leading to hypertension and metabolic dysfunction in the LH rat." @default.
• W2101472374 created "2016-06-24" @default.
• W2101472374 creator A5019162113 @default.
• W2101472374 creator A5025823533 @default.
• W2101472374 creator A5038918740 @default.
• W2101472374 creator A5046300035 @default.
• W2101472374 creator A5046323414 @default.
• W2101472374 creator A5049803595 @default.
• W2101472374 creator A5058475820 @default.
• W2101472374 creator A5070802128 @default.
• W2101472374 creator A5080101531 @default.
• W2101472374 creator A5085142676 @default.
• W2101472374 date "2004-11-01" @default.
• W2101472374 modified "2023-09-30" @default.
• W2101472374 title "Mapping the Genetic Determinants of Hypertension, Metabolic Diseases, and Related Phenotypes in the Lyon Hypertensive Rat" @default.
• W2101472374 cites W1753527095 @default.
• W2101472374 cites W1963786070 @default.
• W2101472374 cites W1971253815 @default.
• W2101472374 cites W1972725067 @default.
• W2101472374 cites W1976741643 @default.
• W2101472374 cites W1999011145 @default.
• W2101472374 cites W2014977165 @default.
• W2101472374 cites W2020960792 @default.
• W2101472374 cites W2024959824 @default.
• W2101472374 cites W2025661760 @default.
• W2101472374 cites W2036567101 @default.
• W2101472374 cites W2061744749 @default.
• W2101472374 cites W2065140183 @default.
• W2101472374 cites W2070091613 @default.
• W2101472374 cites W2084753433 @default.
• W2101472374 cites W2093285783 @default.
• W2101472374 cites W2097040991 @default.
• W2101472374 cites W2097748223 @default.
• W2101472374 cites W2124768606 @default.
• W2101472374 cites W2127120893 @default.
• W2101472374 cites W2146044479 @default.
• W2101472374 cites W2148871416 @default.
• W2101472374 cites W2154675483 @default.
• W2101472374 cites W2167596989 @default.
• W2101472374 cites W2184870906 @default.
• W2101472374 cites W4235656796 @default.
• W2101472374 doi "https://doi.org/10.1161/01.hyp.0000144542.57306.5e" @default.
• W2101472374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15452030" @default.
• W2101472374 hasPublicationYear "2004" @default.
• W2101472374 type Work @default.
• W2101472374 sameAs 2101472374 @default.
• W2101472374 citedByCount "53" @default.
• W2101472374 countsByYear W21014723742012 @default.
• W2101472374 countsByYear W21014723742013 @default.
• W2101472374 countsByYear W21014723742014 @default.
• W2101472374 countsByYear W21014723742015 @default.
• W2101472374 countsByYear W21014723742016 @default.
• W2101472374 countsByYear W21014723742017 @default.
• W2101472374 countsByYear W21014723742019 @default.
• W2101472374 countsByYear W21014723742021 @default.
• W2101472374 countsByYear W21014723742022 @default.
• W2101472374 crossrefType "journal-article" @default.
• W2101472374 hasAuthorship W2101472374A5019162113 @default.
• W2101472374 hasAuthorship W2101472374A5025823533 @default.
• W2101472374 hasAuthorship W2101472374A5038918740 @default.
• W2101472374 hasAuthorship W2101472374A5046300035 @default.
• W2101472374 hasAuthorship W2101472374A5046323414 @default.
• W2101472374 hasAuthorship W2101472374A5049803595 @default.
• W2101472374 hasAuthorship W2101472374A5058475820 @default.
• W2101472374 hasAuthorship W2101472374A5070802128 @default.
• W2101472374 hasAuthorship W2101472374A5080101531 @default.
• W2101472374 hasAuthorship W2101472374A5085142676 @default.
• W2101472374 hasBestOaLocation W21014723742 @default.
• W2101472374 hasConcept C104317684 @default.
• W2101472374 hasConcept C112672928 @default.
• W2101472374 hasConcept C126322002 @default.
• W2101472374 hasConcept C127716648 @default.
• W2101472374 hasConcept C134018914 @default.
• W2101472374 hasConcept C142870003 @default.
• W2101472374 hasConcept C180754005 @default.
• W2101472374 hasConcept C2777097880 @default.
• W2101472374 hasConcept C2779234561 @default.
• W2101472374 hasConcept C2780578515 @default.
• W2101472374 hasConcept C511355011 @default.
• W2101472374 hasConcept C54355233 @default.
• W2101472374 hasConcept C71924100 @default.
• W2101472374 hasConcept C81941488 @default.
• W2101472374 hasConcept C84393581 @default.
• W2101472374 hasConcept C84597430 @default.
• W2101472374 hasConcept C86803240 @default.
• W2101472374 hasConceptScore W2101472374C104317684 @default.
• W2101472374 hasConceptScore W2101472374C112672928 @default.
• W2101472374 hasConceptScore W2101472374C126322002 @default.
• W2101472374 hasConceptScore W2101472374C127716648 @default.
• W2101472374 hasConceptScore W2101472374C134018914 @default.
• W2101472374 hasConceptScore W2101472374C142870003 @default.
• W2101472374 hasConceptScore W2101472374C180754005 @default.
• W2101472374 hasConceptScore W2101472374C2777097880 @default.
• W2101472374 hasConceptScore W2101472374C2779234561 @default.
• W2101472374 hasConceptScore W2101472374C2780578515 @default.
• W2101472374 hasConceptScore W2101472374C511355011 @default.
• W2101472374 hasConceptScore W2101472374C54355233 @default.
• W2101472374 hasConceptScore W2101472374C71924100 @default.

• next