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- W2101472580 abstract "Tick saliva has pleiotropic properties that facilitate persistence of the arthropod upon the host. We now describe a feeding-inducible protein in Ixodes scapularis saliva, Salp15, that inhibits CD4(+) T cell activation. The mechanism involves the repression of calcium fluxes triggered by TCR ligation and results in lower production of interleukin-2. Salp15 also inhibits the development of CD4(+) T cell-mediated immune responses in vivo, demonstrating the functional importance of this protein. Salp15 provides a molecular basis for understanding the immunosuppressive activity of I. scapularis saliva and vector-host interactions." @default.
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- W2101472580 date "2002-06-01" @default.
- W2101472580 modified "2023-10-11" @default.
- W2101472580 title "Salp15, an Ixodes scapularis Salivary Protein, Inhibits CD4+ T Cell Activation" @default.
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- W2101472580 doi "https://doi.org/10.1016/s1074-7613(02)00325-4" @default.
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